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Postdoctoral position – Ultrasound and microbubbles to enhance oncolytic virotherapy against solid cancer



The laboratories of Dr Yu and Dr Bourgeois-Daigneault, at the Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM, Québec, Canada), are seeking a highly motivated, creative and ambitious postdoctoral fellow to develop an ultrasound image guided oncolytic virus (OV) enhancing therapeutic strategy against solid cancer.

The selected candidate will have the opportunity to work on this highly innovative collaborative project for which the funding is already secured. The candidate will develop and optimize microbubble (MB) formulations that carry OV sensitizing drugs and candidate OVs, characterize the physical, pharmaceutical and acoustical properties of the functionalized microbubbles, and quantify the release and OV enhancing properties of the platform using in vitro and in vivo experiments. Candidates with experience in lipid or polymer MB synthesis, liposome or nanoparticle drug delivery systems are highly encouraged to apply.

The postdoctoral fellow will be part of young and dynamic research teams working in the fields of oncolytic virotherapy and ultrasound microbubble theranostics against cancer. Under the supervision of the principal investigators, the candidate will have the opportunity to acquire expertise and master the different activities involved in ultrasound mediated drug delivery and oncolytic virotherapy. The selected candidate will be involved at all levels of the project, including the development of analysis strategies, analysis of data, writing of articles for publication in scientific journals, participation in scientific outreach activities (Congresses, conferences, etc.) and supervision of graduate students.

Conditions:
- Start date: Fall 2020 flexible.
- Duration: 1 year renewable
- Lab websites : ; https://www.chumontreal.qc.ca/crchum/chercheurs/francois-yu
https://www.chumontreal.qc.ca/crchum/chercheurs/marie-claude-bourgeois-daigneault

Required Qualifications:
- Ph. D. in pharmaceutical sciences, biomedical engineering, biomaterials, drug delivery systems or other relevant discipline
- Experience with drug delivery, microbubble synthesis, liposome or other delivery vehicles
- Experience with ultrasound based therapeutic approaches is a plus
- Independent, self-motivated, structured and rigorous
- Ability to communicate and write in English. French is also an asset
- Possess strong and effective presentation, communication, organizational, and planning skills

Please send your CV, transcripts, motivation letter and 3 references to and

CRCHUM is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin or disability.

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Recipient: Francois Yu
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