7498| University of Edinburgh, The Roslin Institute| Research Fellow| Vacancy Ref: 041081 We are looking to recruit an ambitious and motivated postdoctoral research fellow on a 5y position to investigate microglial and neuroinflammatory mechanisms underlying susceptibility and resilience to neurodegenerative disease and dementia. The PDRF will join the McColl neuroimmune biology lab within the recently formed UK Dementia Research Institute (UK DRI) at the University of Edinburgh (https://ukdri.ac.uk/centres/edinburgh). The UK DRI will lead the UK’s dementia research effort to deliver a step-change in the understanding and treatment of dementia-causing disease and should provide a highly stimulating, interactive and cross-disciplinary environment for research. The successful candidate will use a range of in vivo, cellular and molecular approaches (including transcriptomics) to advance understanding of how microglia and neuroimmune mechanisms contribute to neurodegenerative disease. Key guiding questions include (i) what are the consequences of microglial diversity for disease susceptibility and resilience? (ii) what mechanisms, intrinsic and non-cell autonomous, govern helpful and harmful microglial activity? (iii) can resilience mechanisms be augmented to prevent or delay disease progression? Prior experience working with in vivo models of neurodegenerative disease and complementary skills in techniques such as behavioural analysis, cell isolation/phenotyping and molecular biology are highly desirable. Applicants should have a PhD/PhD near copmletion (or equivalent) in a relevant biomedical science. The successful candidate is expected to work well independently and as part of a team comprising other postdoctoral researchers and students working on complementary neuroimmune projects. Informal enquiries can be directed to Dr Barry McColl ([email protected])This post is available on a fixed term basis for 5 yearsClosing Date: 29 September 2017For further particulars and to submit an application, visit the University of Edinburgh’s website via the apply button below.Link: https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=041081

7493| Agri-Food and Biosciences Institute Northern Ireland (AFBI), AFBI| Senior Scientific Officer - Crop Pathology| REF: IRC222008SALARY: £36,448 - £40,072 DEPARTMENT: Agri-Food and Biosciences Institute Northern Ireland (AFBI)LOCATION: AFBI Newforge, BelfastFurther appointments may be made from this competition should AFBI positions become vacant which have similar duties and responsibilities.AFBI is seeking to fill a key scientific position which will provide a unique opportunity for an enthusiastic and innovative scientist to lead and manage the crop plant health team which undertakes testing for bacterial, viral and fungal pathogens of arable crops and grasses.Leading a nationally recognised postgraduate research team you will be responsible for the provision, forward planning, and expansion of statutory diagnostic and advisory services within AFBI, developing strategic management initiatives, maintaining high standards of corporate governance, budget planning and control and staff management.With a PhD in a scientific discipline related to agriculture or plant science, you will have at least two years’ experience of working in plant pathology, plant virology, plant bacteriology or plant nematology and a proven track record in winning and managing a funded research project. For more detailed information and to apply, please go to www.nicsrecruitment.org.ukAlternatively, an application pack can be requested by contacting:HRConnect, PO Box 1089, The Metro Building, 6-9 Donegall Square South, Belfast, BT1 9EW. Telephone: 0800 1 300 330. Email: [email protected] requests must include your name, address and reference number IRC222105Completed application forms must be returned to arrive not later than 12:00 noon (UK time) on Friday 6th October 2017.Applications are particularly welcomed from Roman Catholics and females as these groups are currently under-represented within AFBI.AFBI is an Equal Opportunities EmployerALL APPLICATIONS FOR EMPLOYMENT ARE CONSIDERED STRICTLY ON THE BASIS OF MERIT

7458| Division of Molecular Pathology, ICR, The Institute of Cancer Research| Postdoctoral Training Fellow - Systems & Precision Cancer Medicine| A Postdoctoral Training Fellow position in molecular medicine is available to play a key role in facilitating the research of the Systems and Precision Cancer Medicine Team (Team Leader Anguraj Sadanandam). Our interdisciplinary lab focuses on personalized medicine and companion diagnostics using cancer subtypes and evolution by integrating multi-omics (molecular and metabolism) and phenomics (phenotypes) data. We perform this by integrating wet-lab science with computational biology skills by cross-comparing and integrating high-throughput data (including whole tumour and single cell omics data and cross-species analysis) between patients and in vivo and in vitro models. To this end, we have classified different tumor types including breast cancer cell lines, and pancreatic and colorectal tumours and cell lines into distinct molecular and/or drug response subtypes (PNAS 2012, Nature Medicine 2011, 2013 and 2015, and Cancer Discovery 2015). For more information please visit: http://www.icr.ac.uk/our-research/researchers-and-teams/dr-anguraj-sadanandam and http://www.icr.ac.uk/news-archive/scientists-uncover-four-different-types-of-bowel-cancer You will help us in characterize biomarkers identified in pancreatic, colorectal or breast cancers primarily using patient samples and in vivo and in vitro models. You will also be involved in testing subtype-specific therapies using pre-clinical trials. You will enjoy working in the interdisciplinary fields and collaborating with our internal and external collaborators. Your responsibilities will include day-to-day laboratory operations such as cell culture, different molecular biology and biochemical techniques (including, but not limited to DNA, RNA and protein isolation, isolation, RT-PCR, Western blots, immunohistochemistry, flow cytometry, and in vitro and in vivo experiments and interpretation of the results. In addition, you will work closely with the team and other collaborators to develop and validate hypothesis that will arise out of the high-throughput omics data including genomics and metabolomics. The successful applicant will hold a PhD in molecular medicine or cancer biology and have experience in in vivo (patient-derived/cell-derived xenograft) models performing pre-clinical trials in cancer. Experience in handling patient tumour tissues, laboratory management, molecular biology and biochemical techniques, cell culture and in vivo experiments is essential as well as excellent organizational, scientific writing and communication skills. Experience in statistical data analysis and computational biology/bioinformatics would be advantageous.This is an excellent opportunity for an independent and motivated individual to work in an exciting and highly collaborative environment. The position is offered on a fixed term 1 year contract. The full salary scale for this post is in the range from £30,410 to £43,463 p.a. inclusive. Starting salary will be based on postdoctoral experience. The position will be based in Sutton.Informal enquiries can be made to Dr Anguraj Sadanandam ([email protected]cr.ac.uk). Please DO NOT send your application to Dr. Sadanandam, formal applications must be submitted online.To apply please upload your CV and covering letter (addressing where you meet the person specification and incl. the names and addresses of two referees) online.

1039687| Request Technology - Anthony Honquest| Senior Thermal Engineer| Senior Thermal Engineer Milpitas CA $100-120K Prestigious Company is seeking a dynamic and proactive Sr. Thermal Design Engineer to be a major contributor in the design and development of thermal attributes of Company electronic solutions. The Thermal Design Engineer will have a well-equipped thermal test laboratory available to provide quality empirical test results and verifications. Essential Functions: Develop thermal simulations of designs and correlate the simulations through empirical testing. Interface with various product development teams. These multi-discipline teams include customers, suppliers, electrical engineers, mechanical engineers, manufacturing, quality, and marketing. Evaluate new thermal technologies, new materials, new cooling solutions, and provide guidance to R&D and business teams. Job Requirements Required Qualifications: Bachelor's Degree in Engineering. 5+ years' experience in a CFD-focused (Computational Fluid Dynamics) role. 3+ years' work experience in electronic cooling and thermal compliance in the electronics industry. 3+ years' work experience with IcePak and/or FloTherm. 2 years' CAD experience (preferably NX or SolidWorks). 2 years' experience with heat sink design and material selection and thermal interface material selection 2 years' of hands-on experience building test samples, installing thermocouples, using a wind tunnel, performing thermal tests, and collecting temperature, flow, pressure, and power data. Preferred Qualifications: MSEE or PhD in Mechanical Engineering. Skills and Abilities: Thorough understanding of thermal principles, forced convection cooling, and natural convection cooling. Skilled in Microsoft Outlook, Word, Excel, and PowerPoint. Project management skills that demonstrate the ability to set goals and priorities to complete projects on time. Excellent troubleshooting & problem solving skills.

7468| Medical Research Council, Toxicology Unit| Postdoctoral Research Scientist| Postdoctoral Research Scientist Medical Research Council -Toxicology Unit, Leicester£30,162 - £38,545 (MRC Band 4) or £37,395 - £47,237 (MRC Band 3)*Fixed term for 5 years (funded by CRUK)The Medical Research Council Toxicology Unit, located at the University of Leicester, is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities and offers excellent opportunities for postdoctoral development.The Unit is currently in the process of transferring to the University of Cambridge. Legal transfer will take place in March 2018; the physical relocation is expected to take place in early 2020. We are looking to appoint an enthusiastic Research Scientist to join the MicroRNA Regulation of Gene Expression Group led by Professor Martin Bushell to work on a large consortium program grant funded by the Cancer Research UK to investigate “Targeting dysregulated translational control in the tumour environment” in collaboration with Dr Le Quesne (MRC Toxicology Unit) and Professors Sansom and Norman from the CRUK Beatson Institute. Oncogenes are exquisitely dependent upon the eIF4F initiation complex, which unwinds mRNA structure and facilitates ribosome recruitment, for their translation. It acts as a signalling hub positioned at the end of several mitogenic pathways, and its upregulation is a common feature of malignancy and leads to drug resistance. You will will make a significant input into determining the direction of the project and participate in collaborative research, both within and external to the Toxicology Unit.The main aims of the project will be: 1. To establish the mechanisms through which eIF4A paralogues sculpt the translational landscapes associated with proliferating and differentiated cells, especially within stromal and epithelial compartments of tumours.2. To achieve selective disruption of eIF4A paralogues in mouse models of colon, pancreatic and lung cancers and their associated stromal fibroblasts, and to determine the effects of this on tumour growth, invasion and metastasis.3. To determine whether eIF4F complex dysregulation is a universal underlying feature of human malignancy, how this occurs, and whether this helps to identify patient groups who are likely to benefit from particular anti-eIF4F strategies.You will have been awarded (or in the final stages of obtaining) a PhD in a biological sciences subject, particularly RNA biology or translation control. Experience of cloning, mammalian tissue culture, western blotting, qPCR, immunofluorescence and RNA biology techniques is essential. Knowledge of techniques aimed at assessing translation control, particularly deep-sequencing approaches (ribosome profiling) or array based methods is required. Experience or training in bioinformatics and advanced cell culture is desirable.You will be committed to working at a highly competitive level, able to communicate scientific ideas effectively and have published (or about to publish) in a peer-reviewed journal.Choosing to come to work at the MRC means that you will have access to a whole host of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme and childcare vouchers, as well as the chance to put the MRC on your CV in the future.*Appointment to MRC Band 3 requires significant relevant postdoctoral experience and evidence of a trajectory towards independence, including a strong publication record.For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/691 and upload your CV along with a covering letter. Please quote reference TOX 641.Closing date for applications: 27 September 2017The MRC is an Equal Opportunities Employer. Final appointments will be subject to pre-employment screening.The MRC Toxicology Unit is a member of Athena Swan.

7500| Cranfield University, School of Water, Energy and Environment| Research Assistant in Modelling Root Traits to Bio-engineer Soil| 3 year Fixed Term contract (to commence 1 January 2018 or as soon as possible thereafter)£23,837 to £27,304 per annum with additional performance related pay up to £32,094 per annum (Research Assistant) £32,094 per annum (Research Fellow)Location: Cranfield, BedfordshireCranfield is an exclusively postgraduate university that is a global leader for education and transformational research in science, technology and management. The Soil and Agrifood Institute has internationally-recognised expertise and some of the best soils research facilities in Europe, as well as hosting national and international soil data assets.You will contribute to a 3 year project funded by the BBSRC 'Using plant roots to bio-engineer soil'. The aims are to develop a novel model to select and combine complementary root traits in cover crops that prevent soil resource losses and improve crop growth conditions. No study has looked at the effects of root properties of cover crops to synergistically enhance multiple soil functions. You will help develop a model to combine complementary root traits in plant communities and to model their effects on multiple soil functions. You will also perform root screening with ten common cover crops (oat, rye, ryegrass, Festulolium, buckwheat, mustard, fodder radish, phacelia, Lucerne and vetch) grown in the lab and in the field, under different environments prone to soil degradation.You must have a PhD (obtained or near completion) in the field plant-soil analysis and modelling of plant-soil interactions, alongside experience in statistical analysis of complex data and mathematical modelling. You will have excellent project and time management skills, and oral and written communication skills for mixed audiences. You will need to be willing to travel to field test sites and to work with project partners in the agri-business and environmental policy sector.For an informal discussion, please contact Dr. Sarah De Baets at [email protected] University is committed to promoting a harmonious working and learning environment where everyone is treated with respect and dignity, recognising that the contribution of all its people will be most effective in conditions which are inclusive.We are signatories to the Athena SWAN Charter and achieved a Bronze Opportunity Now Award. We also run the Leadership Foundation’s Aurora Programme. Your career at Cranfield will be enhanced through access to extensive research and business training through our learning and development team and doctoral training centres in a collegiate and supportive environment.Your career at Cranfield will be enhanced through access to fully equipped shared laboratory and pilot facilities, extensive research and business training through our learning and development team and doctoral training centres in a collegiate and supportive environment.Apply online now at www.cranfield.ac.uk/hr or contact us for further details on E: [email protected] or T: +44 (0)1234 750111 Ext. 2342. For any enquiries, please quote reference number 2531. Closing date for receipt of applications: 30 October 2017Interviews to be held: 15 November 2017www.cranfield.ac.uk

1039639| Request Technology - Robyn Honquest| C++ Trade Application Developer| C++ Software Developer - Recent Grads Looking for a candidate with C++ Multithreading, advanced degree in CS or math or statistics or PhD, high GPA, average, will look at recent grads. Must have algorithym background, UNIX, Linux, Shell Scripting. Hiring software developers to join our auto-trading platform group. We are looking for people to develop, enhance, and support our platform, including directed research and implementation of trading strategies. Duties and Responsibilities Develop and enhance auto-trading platform Work with strategists to implement trading models Help strategists with research and development of trading strategies Experience and Skills Advanced degree in computer science, math or statistics Mastery of C++ and UNIX Shell Scripting Working knowledge of SQL Strong communication skills Work under pressure in a dynamic environment The financial industry experience and Real Time computing preferred

7466| Hamad Bin Khalifa University, College of Science and Engineering| Post-Doc in Computational Fluid Dynamics and Simulation| The Sustainable Energy research group at HBKU is currently recruiting a postdoctoral researcher in the area of computational fluid dynamics. The ongoing research aim is to develop new methods and techniques to model the physics that dictate the fluid flow and transport at the sub-surface level for CO2 sequestration projects. Qatar is considered one of the largest emitters for CO2 per capita in the World, one solution is to reinject the emitted CO2 in depleted sub-surface reservoirs. New computational and discretization techniques are needed to model these complex physical sub-surface flow behaviors. Example areas you might work in include:• Investigating and developing new higher-order discretization techniques for general purpose reservoir simulation.• Investigating the role of sub-surface physics for the feasibility of CO2 injection projects.• Developing a prototype reservoir simulator for high performance computing that include a parallel computing architecture.• Working and collaborating with our partners’ development teams in Qatar and around the world. The successful candidate will be working under the guidance of Dr. Ahmad Abushaikha.About HBKU:Hamad bin Khalifa University (HBKU), a member of Qatar Foundation for Education, Science and Community Development, is an emerging research-intensive university that is building its foundation upon unique collaborations with the best local and international institutions. Located in Education City, Doha, Qatar, HBKU delivers world-class research-based undergraduate and graduate programs through its College of Science and Engineering, Law School, College of Public Health, Qatar Faculty of Islamic Studies, and College of Humanities and Social Science. It also provides unparalleled opportunities for research and scholarship through its research institutes, and its Center of Executive Education delivers customized programs for the business community of Qatar and the region.Qualifications, skills and experience:Applicants should have a Ph.D. in Petroleum/ Hydrological Engineering, Physics, Reservoir Geosciences or Applied Mathematics and have a demonstrated technical background including numerical modelling, discretization methods, parallel programming, and linear solvers. A candidate should have an extensive knowledge in the following areas:• Computational modeling of fluid flow and transport in porous media.• Programming languages such as C++ .• Design of parallel computing architectures.• Linear and non-linear solvers for non-linear problems.

1039641| RM IT Professional Resources AG| Project Manager Drug Formulation| Project Manager Drug Formulation with profound QbD knowledge wanted for our Basel based client in the pharmaceutical sector.Your experience/skills:Degree in Pharmacy or Chemistry, PhD is a big plusRelevant working experience in the development of pharmaceutical formulations ideally oral solid dosage formsExcellent knowledge of laboratory and/or technical tools (eg QbD, statistical software, PAT) as well as solid understanding of QbD and biopharmaceuticalsBroad understanding of development activities and processes in pharmaceutical sciences ( early and late phase development)Proficiency of relevant GLP, GMP regulations and policiesExcellent project management skills and scientific leadership skillsLanguages: fluent English both written and spoken, German and French would be a plusYour tasks:Developing the growing pipeline of pharmaceutical products, oral dosage forms, new technologies and supervision of scientific projectsInsuring that high quality products are developed applying state of the art technologies, risk analysis and QbD methodologiesEnsuring robust formulations and processes through optimization, scale-up and validation work and provision of the required documentation to allow worldwide registrationBeing responsible of implementing QbD principles into development and support its consistent and systematic roll out for the unit projects portfolioRepresenting pharmaceutical development in external collaborations including the management of the development and GMP activitiesStart: ASAP Duration: 24MM+ Location: Basel, Switzerland Ref.Nr.: BH11487Does this sound like an interesting and challenging opportunity to you? Then take the next step by sending us your CV as a Word document and a contact telephone number.Due to work permit restrictions we can unfortunately only consider applications from EU or Swiss citizens as well as current work-permit holders for Switzerland.Going the extra mile New to Switzerland? In case of successful placement, we support you with:All administrative questionsFinding an apartmentHealth - and social insuranceWork permit and much more

1039645| Aspire People| Cover Supervisors needed Sandwell| Are you a Cover supervisor based in Sandwell? Currently experiencing a lack of supply teaching work from your current supply teaching recruitment agency in Sandwell? NQT (Newly Qualified Teacher) looking to get lots of experience in schools around Sandwell? Aspire People is a supply teaching recruitment agency, we currently work with a number of secondary and middle schools in the Sandwell who are looking for a pool of qualified supply teachers to help out with day-to-day and long-term work. Aspire People is the most reputable recruitment agency in Sandwell and The Black Country...why you ask? 1. Flexible supply teaching, work in schools when you want and need to in Sandwell 2. Excellent daily rates of pay for all supply teachers 3. Supply teachers paid to scale after 12 weeks work in a school 4. Face-to-face induction with your very own education recruitment consultant 5. Child protection and safeguarding children induction so all supply teachers are up-to-date. 6. Bank of resources for all supply teachers 7. Your own dedicated recruitment adviser, there for you every step of the way and responsible for finding you local schools that you actually want to teach in. 8. Fast-track supply teacher application process so you can get in to work quickly 9. Expert advice on CVs&teacher interviews 10. Regular updates on education news in Sandwell&The Black Country 11. Facebook group and Twitter page for supply teachers and announcing supply teaching jobs in Sandwell&The Black Country The Cover supervisor teaching job is a great opportunity for anyone looking to get additional experience of working with Secondary aged children in secondary schools. Are you interested in going in to teaching but not quite sure how? Maybe you need to gain a bit of experience before entering on to a PGCE? Maybe you have a large amount of experience teaching but can't find an agency who is willing to help you on to a Graduate Teaching Programme? Are you currently studying a degree, masters or Phd and are only free to teach a couple of days a week? THE BENEFITS OF WORKING WITH SUPPLY TEACHING AGENCY ASPIRE PEOPLE ARE SIMPLE...NOT ONLY WILL WE HELP YOU DEVELOP YOUR TEACHING CAREER BUT SUPPORT YOU EVERY STEP OF THE WAY What should you do next? So if you are interested in QTS supply teaching in Sandwell please get in touch today or head to our website, facebook or twitter pages for more information Aspire People Limited provides services as an Education Agency and an Education Employment Business. Aspire People is committed to safeguarding and promoting the welfare of pupils and expects every candidate to share this commitment. Placements are subject, to appropriate Child Protection screening, including checks with former employers and the Criminal Records Bureau.

1039617| Client Server| Web Developer (Senior) JavaScript UI UX| Web Developer / Front End Developer (JavaScript Angular HTML CSS Agile TDD UI UX). Successful FinTech company that offers a range of investment services to the public via their advanced technology platform which makes smart investing easier and accessible to all is seeking a highly skilled Web Developer. Joining a small, dedicated technology team as a Web Developer you will help design next generation systems, ensuring everything you develop is testable, repeatable and automated including testing. Working closely with the Design Team and Product Managers you will be instrumental in shaping the product, building a beautiful and effective UX. This Web Developer role presents an excellent opportunity to join a successful and growing company that is driven by technology. Offices based in North London. Requirements: *Extensive experience building complex and beautiful web applications with HTML, CSS, JavaScript, Angular, bower, grunt and related frameworks *Good understanding of the principles of design, UI and user experience *Experience with responsive web, browser compatibility and usability *Advocate of Agile development methodologies: Scrum, TDD / BDD *Collaborative team member with strong communication skills *Degree educated, Computer Science preferred (Masters / PhD advantageous) As a Web Developer you can expect to earn a competitive salary (to £70k) plus 25 days holiday and share options. Send your CV or call for a confidential discussion about this Web Developer / Front End Developer opportunity.

1039683| Aspire People| Cover Supervisor Bromsgrove| Are you a Cover supervisor based in Bromsgrove? Currently experiencing a lack of supply teaching work from your current supply teaching recruitment agency in Bromsgrove? NQT (Newly Qualified Teacher) looking to get lots of experience in schools around Bromsgrove? Aspire People is a supply teaching recruitment agency, we currently work with a number of secondary and middle schools in the Bromsgrove who are looking for a pool of qualified supply teachers to help out with day-to-day and long-term work. Aspire People is the most reputable recruitment agency in Bromsgrove and Worcestershire...why you ask? 1. Flexible supply teaching, work in schools when you want and need to in Bromsgrove&Worcestershire 2. Excellent daily rates of pay for all supply teachers 3. Supply teachers paid to scale after 12 weeks work in a school 4. Face-to-face induction with your very own education recruitment consultant 5. Child protection and safeguarding children induction so all supply teachers are up-to-date. 6. Bank of resources for all supply teachers 7. Your own dedicated recruitment adviser, there for you every step of the way and responsible for finding you local schools that you actually want to teach in. 8. Fast-track supply teacher application process so you can get in to work quickly 9. Expert advice on CVs&teacher interviews 10. Regular updates on education news in Bromsgrove&Worcestershire 11. Facebook group and Twitter page for supply teachers and announcing supply teaching jobs in Bromsgrove&Worcestershire The Cover supervisor teaching job is a great opportunity for anyone looking to get additional experience of working with Secondary aged children in secondary schools. Are you interested in going in to teaching but not quite sure how? Maybe you need to gain a bit of experience before entering on to a PGCE? Maybe you have a large amount of experience teaching but can't find an agency who is willing to help you on to a Graduate Teaching Programme? Are you currently studying a degree, masters or Phd and are only free to teach a couple of days a week? THE BENEFITS OF WORKING WITH SUPPLY TEACHING AGENCY ASPIRE PEOPLE ARE SIMPLE...NOT ONLY WILL WE HELP YOU DEVELOP YOUR TEACHING CAREER BUT SUPPORT YOU EVERY STEP OF THE WAY What should you do next? So if you are interested in QTS supply teaching in Bromsgrove please get in touch today or head to our website, facebook or twitter pages for more information Aspire People Limited provides services as an Education Agency and an Education Employment Business. Aspire People is committed to safeguarding and promoting the welfare of pupils and expects every candidate to share this commitment. Placements are subject, to appropriate Child Protection screening, including checks with former employers and the Criminal Records Bureau.

7452| THE CANCER RESEARCH UK MANCHESTER INSTITUTE| Postdoctoral Scientist in Stem Cell Biology - investigating the development of the haematopoietic system| •Job Ref: MI/17/55 •Commencement of post: January 2018•Duration of post: 3 years (in first instance)We are looking for a highly motivated Postdoctoral Scientist to join the laboratory of Professor Georges Lacaud to investigate the development of the haematopoietic system. Understanding how blood cells are generated is important from a biological perspective but has also tremendous potential implications for the treatment of blood diseases. The successful candidate will perform single cell expression and epigenetic analyses, in collaboration with our Bioinformatician, to reveal new hierarchical relationships, infer pathways of differentiation and uncover new regulatory interactions sustaining blood development. The hypotheses generated in silico will be evaluated using state-of-the-art mouse models, CRISPR genome editing and ES cell cultures.The applicant should have a PhD in molecular or cellular biology. A background in developmental haematopoiesis is desirable but not required. Informal enquiries should be directed to Georges Lacaud ([email protected]).The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire, England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside. We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. The Institute has outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry. To apply for this position please visit our website: www.cruk.manchester.ac.uk For applicants who are unable to download this information from our website, please contact HR department on 0161 306 0840, email: [email protected] to have this information sent by post.Closing date: 25 September 2017.

7502| Dr. Alexandre PUISSANT, Jean Bernard Center (INSERM U944)| Computational Biologist in Acute Myeloid Leukemia Research| We are looking for a highly motivated candidate with a strong background in data analysis, statistics and in programming in R and/or Python, and an extensive experience in NGS data analysis (RNA-seq, ChIP-seq,WES). In addition, the candidate should able to run comparative marker, GSEA, ssGSEA, EdgeR/RIGER, and ICA analyses, be familiar with the use of cBioPortal or MSigDB datasets, and be able to implement their data on GENE-E/Morpheus and IGV softwares. Applicants should hold a PhD degree in Computational Sciences or related disciplines (or have recently submitted their thesis with scheduled defense).The computational biologist position will be opened in March 2018 for three years (renewed each year) in the laboratory of research on molecular basis of Acute Myeloid Leukemia headed by anERC / ATIP-AVENIR team leader Dr. Alexandre PUISSANT ( https://thepuissantlab.jimdo.com/ ).The Puissant laboratory deciphers molecular mechanisms involved in leukemia development in pre-clinical mouse models of AML. Unbiased in vivo screening approaches are deployed in order to provide new therapeutic strategies to treatAML.Large-scale shRNA screening, genetic, biochemical, cell biological, as well as genome-wide approaches (WES, RNA-Seq, ChIP-Seq) are currently used in this lab.THE TEAM:The Puissant laboratory is housed at the Jean Bernard Center (INSERM U944) which is located at the Saint-Louis Hospital campus in Paris, France . The research developed in this institute encompasses a broad spectrum of fields, including cancer genomics, cancer biology and leukemia research. Most studies carried out in the unit have implications in translational research, together with clinical groups of the Saint-Louis Hospital. Our laboratory benefits from a direct access to the core facilities including: a recently extended animal facility, a sequencing facility (Mi-seq, Hi-seq, and Next gen-seq technologies), and a flow core facility.HOW TO APPLY:Thanks to send your application (in French or English) to alexandre.puissant(at)inserm.fr before February 1st 2018 , by including in one single pdf file (applicantName_application2018.pdf):- description of the main past achievements and skills of the candidate (max 2 pages);- full Curriculum Vitae;- contact details of three individuals who can be contacted for recommendation letters.

7484| Swedish University of Agricultural Sciences, Chemical Ecology of Disease Vectors Unit, Department of Plant Protection Biology| The evolution of mosquito preference for humans| The Department of Plant Protection is an interdisciplinary constellation with good opportunities for strong research collaboration within and outside the departmental area (www.slu.se/en/departments/plant-protection-biology/). World-leading research is conducted in chemical ecology/sensory biology, and successful research is also conducted in resistance biology and integrated plant protection. The research efforts are directed towards both fundamental and applied research. At the Department, one group focusses on the chemical ecology of disease vectors. Female mosquitoes are major vectors of human disease and the most dangerous are those that preferentially bite humans. Host selection and discrimination by mosquitoes are mainly odour mediated. Understanding the genetic causes and effects of host choice in sympatric, closely related species is challenging, controversial and of significant practical importance for controlling these rapidly evolving vectors (www.slu.se/en/cv/sharon-hill/; www.slu.se/en/cv/rickard-ignell/). Duties:The research describes the genetic mechanism linking the basic molecular building blocks of the peripheral olfactory system with the ‘inherent’ host preference displayed by sibling malaria mosquito species using suitable techniques. The postdoc will be involved in a project that identifies the genetic changes resulting in minor structural differences that change odorant receptor and receptor neuron response to host odours among three sibling species of malaria mosquitoes that display different preferences for humans as a host. To investigate the mechanism underlying such functional changes in the receptors due to polymorphisms, the receptors will be functionally assessed in response to host odours. These findings will subsequently be investigated at the receptor neuron and behavioural levels.Qualifications:The successful candidate will hold a PhD, issued no earlier than 3 years ago. Experience with common molecular biological techniques is a requirement. In addition, experience with cell-based membrane protein expression and assay systems is a significant asset. S/he should be fluent in spoken and written English, and have excellent communication skills. The candidate must demonstrate a solid ability to work independently to advance our research. The candidate should furthermore enjoy working in a group environment and have interest in mentorship.Place of work: Alnarp, SwedenForm of employment: Stipend 1 yearExtent: 100%, Full timeStarting date: 1 January 2018Application: We welcome your application marked Mosquito Postdoc.Please submit your application to associate professor Sharon Hill ([email protected]) no later than 1 November 2017.Specific documents attached: Applications must contain (1) CV with full publications list, (2) copies of the two most important publications, (3) a description of research experiences, (4) a statement of scientific interests, as well as (5) contact information of two references.SLU is an equal opportunity employer.Further information:Sharon Hill, Associate professor+46(0)40 41 53 79 (office)+46(0)70 72 63 94 (mobile)[email protected]/en/cv/sharon-hill/ Rickard Ignell, Head of department+46(0)40 41 53 [email protected] www.slu.se/en/cv/rickard-ignell/The Swedish University of Agricultural Sciences (SLU) develops the understanding and sustainable use and management of biological natural resources. The university ranks well internationally within its subject areas. SLU is a research-intensive university that also offers unique degree programmes in for example rural development and natural resource management, environmental economics, animal science and landscape architecture. SLU has just over 3,000 employees, 5,000 students and a turnover of SEK 3 billion. The university has invested heavily in a modern, attractive environment on its campuses in Alnarp, Umeå and Uppsala.www.slu.se/en/ The Faculty of Landscape Architecture, Horticulture and Crop Production Science (LTV) at campus Alnarp has five departments. Education and research activities are focused around landscape architecture, horticulture, crop production and agriculture to meet the global challenge to provide the world’s growing population with food, clean water, fibres, materials and energy using sustainable methods.

1039646| Aspire People| Cover Supervisor Bromsgrove| Are you a Cover supervisor based in Bromsgrove? Currently experiencing a lack of supply teaching work from your current supply teaching recruitment agency in Bromsgrove? NQT (Newly Qualified Teacher) looking to get lots of experience in schools around Bromsgrove? Aspire People is a supply teaching recruitment agency, we currently work with a number of secondary and middle schools in the Bromsgrove who are looking for a pool of qualified supply teachers to help out with day-to-day and long-term work. Aspire People is the most reputable recruitment agency in Bromsgrove and Worcestershire...why you ask? 1. Flexible supply teaching, work in schools when you want and need to in Bromsgrove&Worcestershire 2. Excellent daily rates of pay for all supply teachers 3. Supply teachers paid to scale after 12 weeks work in a school 4. Face-to-face induction with your very own education recruitment consultant 5. Child protection and safeguarding children induction so all supply teachers are up-to-date. 6. Bank of resources for all supply teachers 7. Your own dedicated recruitment adviser, there for you every step of the way and responsible for finding you local schools that you actually want to teach in. 8. Fast-track supply teacher application process so you can get in to work quickly 9. Expert advice on CVs&teacher interviews 10. Regular updates on education news in Bromsgrove&Worcestershire 11. Facebook group and Twitter page for supply teachers and announcing supply teaching jobs in Bromsgrove&Worcestershire The Cover supervisor teaching job is a great opportunity for anyone looking to get additional experience of working with Secondary aged children in secondary schools. Are you interested in going in to teaching but not quite sure how? Maybe you need to gain a bit of experience before entering on to a PGCE? Maybe you have a large amount of experience teaching but can't find an agency who is willing to help you on to a Graduate Teaching Programme? Are you currently studying a degree, masters or Phd and are only free to teach a couple of days a week? THE BENEFITS OF WORKING WITH SUPPLY TEACHING AGENCY ASPIRE PEOPLE ARE SIMPLE...NOT ONLY WILL WE HELP YOU DEVELOP YOUR TEACHING CAREER BUT SUPPORT YOU EVERY STEP OF THE WAY What should you do next? So if you are interested in QTS supply teaching in Bromsgrove please get in touch today or head to our website, facebook or twitter pages for more information Aspire People Limited provides services as an Education Agency and an Education Employment Business. Aspire People is committed to safeguarding and promoting the welfare of pupils and expects every candidate to share this commitment. Placements are subject, to appropriate Child Protection screening, including checks with former employers and the Criminal Records Bureau.

7472| King's College London, Wolfson Centre for Age-Related Diseases| Postdoctoral Research Associate - Wolfson Centre for Age-Related Diseases,| Postdoctoral Research AssociateWolfson Centre for Age-Related DiseasesGrade 6, £33,518 per annum plus £2,923 per annum London AllowanceFixed-term, full-time for 28 monthsRef: R6/PNW/1816/17-SSWe are seeking a full-time Postdoctoral Scientist for an international research effort funded by the European Union (IMI2). You will be joining the UK arm, led by Prof Stephen McMahon and Dr Franziska Denk at King’s College London. The project aims to improve our understanding of chronic pain states, particularly those caused by neuropathic injuries arising from trauma or cancer treatment. The successful applicant will lead studies involving co-cultures of purified cell types, including peripheral sensory neurons, glia and immune cells. You will be joining a multidisciplinary research community at the Wolfson Centre for Age-Related Diseases, where your research will benefit from the input of many friendly colleagues and the joint supervision of two investigators who combine the best of two worlds: advice and inspiration from one of the pre-eminent leaders in pain research and practical day-to-day guidance on research techniques from a junior PI.The deadline for applications is midnight on the 2nd of October 2017The selection process will include competency based questions in a panel interview, a presentation and a practical assessment. Interviews are scheduled to be held the week commencing the 9th of October. For further information, don’t hesitate to contact us ([email protected]) and feel free to consult our websites:http://www.franziskadenk.com http://www.kcl.ac.uk/ioppn/depts/wolfson/research/McMahon-Lab/McMahon-Lab.aspx To apply for this role, please visit https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=77811 Register to download the specified application.

1039653| Global Resourcing| Wifi Systems Architect| Location: Shanghai, China Job type: permanent A world-class player smartphone and telecoms equipment is urgently seeking an experienced technical expert in the Wifi system domain to join one of their R&D centres. You will take a principal role in an international team and help determine the direction of future product development. Responsibilities of the Wi-Fi System Architect: n Lead in the connectivity system team (SE) (Wi-Fi/Bluetooth/NFC), including evaluation of chipsets, subsystems and complete wireless system solutions, and driving technology roadmaps n Collaborate with the engineering teams and IOT Ecosystem, to develop and document wireless network architecture requirements, standards and design specifications n Maintain solid working knowledge of state-of-the-art wireless systems, such as 802.11ad/ax, LAA, BT5.x, NFC_EMVCo_POS n Plan and execute lab and field tests of various subsystems from chipset evaluation platforms through to complete wireless system solutions, characterizing performance n Deliver clear, concise professional verbal and written communication that is appropriate to the situation and audience. Requirements for the Wi-Fi System Architect: n Experience with designing, developing and testing Wi-Fi, 802.11ad/ax or other mmWave technologies, in-depth knowledge of the MAC layer of 802.11 systems n Experience with Wi-Fi/Bluetooth/NFC system integration, has 5+ Smartphone commercial projects n Experience with Wi-Fi/BT/NFC interoperability issue and associated enhancement design n Experience with Cloud sourcing and big data analysis of consumer devices n Experience with developing and executing test plans, including experience with test case automation n Exceptional collaboration, listening, written and verbal communication skills, including an ability to clearly communicate with both business and technical audiences n 8+ years of chipset industry experience n MSEE or higher degree, PhD will be a plus. Wi-Fi System Architect

7477| Adam Mickiewicz University, Department of Physics| Postdoc - DNA repair| Postdoc position available!Newly funded laboratory „Single-molecule biophysics of DNA repair“ opens position for postdoc available from 1st October 2017. The position is fully funded for 2 years (4 500PLN/net income) with the possibility of extention for additional year. The project is focusing on understanding of DNA repair, both in vitro and in vivo, of nucleotide excision repair pathway in bacteria. Methodology is mostly based on cutting-edge single-molecule technologies including single-molecule FRET and super-resolution microscopy. The project is the collaboration between laboratories in Poznan University (Department of Physics), International Institute of Molecular and Cellular Biology in Warsaw and Oxford University (Department of Biochemistry). Majority of time applicants will spend in Poznan (Poland), however frequent visits to Warsaw and Oxford (UK) are planned.PhD in molecular biology, biochemistry, cell biology or biophysics is required and any experience in single-molecule technologies would be an advantage. Applicants expecting to obtain PhD shortly are encouraged to apply. Closing date: 25.09.2017If interested, please contact directly (CV and covering letter) the head of the project: dr Pawel Zawadzki ([email protected]).Literature:Stracy M., Jaciuk M., Uphoff S., Kapanidis A., Nowotny M., Sherratt DJ., Zawadzki P. (2016) UvrA initiates nucleotide excision repair by recruiting UvrB from solution to DNA lesions. (Nature Communications)Zawadzki P., Stracy M., Ginda K., Lesterlin C., Zawadzka K., Kapanidis A., and Sherratt DJ. (2015) The localization and action of topoisomerase IV in Escherichia coli chromosome segregation is coordinated by the SMC complex, MukBEF. (Cell Reports)Zawadzki P., May P., Pinkney J.N.M., Baker R., Kapanidis N.A., Sherratt J.D., Arciszewska K.L. (2013) Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes. (PNAS)Please include in your offer:“I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

7457| Division of Breast Cancer Research, Gene Function Team, ICR, The Institute of Cancer Research| Postdoctoral Training Fellow (x4) - Gene Function| The Gene Function Laboratory, headed by Professor Chris Lord, focuses upon identifying and understanding tumour specific dependencies, such as synthetic lethal effects, as a means to design novel approaches to treating cancer. We have made major advances in identifying synthetic lethal interactions involving, for example, PARP inhibitors (Farmer et al Nature (2005), Edwards et al Nature (2008), Bajrami et al, Cancer Research (2014)) and ATR inhibitors (Williamson et al, Nature Communications (2016)). Using this same concept we have also systematically identified synthetic lethal interactions in breast cancer (Brough et al, Cancer Discovery (2011), Campbell et al, Cell Reports (2016)). We aim to generate pre-clinical information that can inform the design of clinical trials and the identification of novel targets for drug discovery programmes.We are seeking highly motivated Postdoctoral Training Fellows (x4) to study synthetic lethal effects, with the express aim of developing optimised treatment approaches for cancer. At the present time, we are particularly interested in investigating synthetic lethal interactions in the following areas:• SWI/SNF tumour suppressor genes (Williamson et al, Nature Communications 2016) focusing on interactions with the DNA damage response (DDR) pathway.• Synthetic lethal interactions between the RB tumour suppressor gene and the DDR, leveraging our previous studies (Brough et al. Cancer Discovery 2011).• Synthetic lethal interactions that are associated with E-cadherin loss in breast cancer.• DDR related synthetic lethalities in pancreatic cancer.Successful applicants will use a combination of high-throughput in vitro and in vivo functional genomic approaches to identify therapeutic targets. These may include the use of RNA interference, CRISPR-Cas9 and drug screens. We would expect successful candidates to contribute to the development of a project and research plan that makes the most of the resources and interests of the laboratory as well as the candidate’s specific skill set and experience. Candidates should possess a PhD in biology, genetics or other associated subjects, experience in molecular and cellular biology and a strong track record of high quality biomedical research as exemplified by their publication record. Successful applicants will enjoy working in an interdisciplinary environment with our internal and external biology, clinical, pathology and computational biology collaborators. The post holders will be fast learners, and will be motivated to explore new subjects. Appointment will be on a Fixed Term Contract for 2 years in the first instance, with a starting salary in the range of £30,410 p.a. to £43,463 p.a. inclusive. Starting salary will be based on postdoctoral experience. Interviews are expected to take place on 11 October 2017.To apply, please upload your CV and covering letter online.Informal enquiries are welcome and can be made via email to Dr Stephen Pettitt ([email protected]). Please note – this address is for enquiries only and you should not send your application to this email address.

7479| University of Otago, The Department of Preventive and Social Medicine| Postdoctoral Fellow in Preventive and Social Medicine| DEPARTMENT of PREVENTIVE and SOCIAL MEDICINEOur DepartmentThe Department of Preventive and Social Medicine is one of seven Departments within the Dunedin School of Medicine. Our work is broad and varied within the field of Public Health and includes; seeking to understand why some people are healthy and some are not; how to prevent illness and injury; how people’s health can be improved through working with communities; how political systems and health organisations affect health; and other issues relating to the health of populations.The RoleAs a Postdoctoral Fellow, you will be primarily responsible for supporting the Head of Department by facilitating research in Public Health Epidemiology, with a focus on studies of infectious diseases, risk factors, transmission and prevention.Your Skills and Experience• Hold a doctoral degree in Epidemiology or a related discipline.• Enjoy all aspects of Public Health research, including critically reviewing literature, data collection, management, analysis, preparing manuscripts and other forms of dissemination.• Have excellent written and oral presentation skills.• Be able to engage and communicate effectively with research collaborators.• Be able to take direction, then self-motivate and work independently to produce high quality work.The position would suit someone seeking experience while in transition to becoming an independent researcher in Epidemiology.Further DetailsThis is a fixed-term position for two and a half years at 0.8FTE; based in Dunedin, New Zealand.ApplicationTo submit your application please click the ‘apply’ button below. Applications quoting reference number 1701654 will close on Sunday, 24 September 2017.

7482| Centre for Genomic Regulation CRG| PostDoc Position on Ageing and Fertility| We are looking for a highly skilled and motivated candidate to join our group for a PostDoc position. In the Payer lab (http://www.crg.eu/bernhard_payer), we study epigenetic reprogramming in the mammalian germ line and the effects of ageing on fertility. In this project, which will be performed in collaboration with a fertility clinic, the prospective candidate will study molecular links between ageing and fertility decline in women.We are seeking a candidate with a strong background in Mammalian Cell Culture, Stem Cell Reprogramming and Differentiation, Epigenetics, Reproduction and Molecular Biology. Excellent candidates from other related fields will also be considered.Work EnvironmentOur lab is part of the Gene Regulation, Stem Cells & Cancer Programme at the Centre for Genomic Regulation (CRG) in Barcelona, Spain (www.crg.eu). The CRG is a vibrant International Research Institute with Research Groups working in diverse fields such as Genomics, Cell and Developmental Biology, Systems Biology, Stem Cells, Cancer and Epigenetics. English is the working language.Eligibility• Candidates can be of any nationality, but must undertake trans-national mobility and must not have resided or carried out their main activity in Spain for more than 12 months in the 3 years prior to the call deadline. Furthermore, applicants working at CRG for more than 3 months before the deadline will not be considered.• Candidates must have a PhD degree from a recognized university, plan to obtain a PhD degree by the time of employment, or have at least four years of full-time equivalent research experience. Candidates who already hold a PhD degree at the time of application are eligible to apply only if they passed their PhD exam (or equivalent) in the four years prior to the call deadline. Exceptions up to 3 years for maternity/paternity leaves and other documented career breaks will be considered.• Candidates must have at least one publication as first author (either in press or published) at the time of the deadline• Candidates must provide two letters of referenceFellowship36 months by the INTREPiD Fellowship programme.Applications are accepted exclusively online through:http://www.crg.eu/intrepid_fellowshipsThe application deadline is the 19th of November 2017, at 5:00pm (local time).For informal questions regarding the position, please contact: [email protected]

7464| The Institute of Cancer Research, London, Breast Cancer Research| Postdoctoral Training Fellow - Cell Death & Inflammation - Immunogenic Cell Death| The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally. The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research and its goal is to advance research into the causes, diagnosis and treatment of breast cancer. Formerly known as The Breakthrough Toby Robins Breast Cancer Research Centre, at The Institute of Cancer Research, London, it is located in state-of-the-art laboratory space, with excellent core facilities and funding. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer. The Cell Death and Inflammation Team, led by Professor Pascal Meier, is focussing on the complex relationship between cell death and inflammation, and how this can be exploited to prevent tumour relapse and stimulate long-lasting immunological protection. Improving treatment outcome requires understanding the basic mechanisms by which anti-cancer agents kill tumour cells, and how we can further improve their efficacy to prevent tumour relapse.The success of future anti-cancer therapies will require efficient stimulation of host immune responses. Notably, dying cells initiate adaptive immunity by providing both antigens and inflammatory stimuli for dendritic cells, which in turn activate CD8+ T cells via antigen cross-priming. Certain types of cell death (necroptosis) are especially immunogenic and elicit robust cross priming. Accordingly, necroptotic signalling in dying cells orchestrates adaptive immunity and can provide long-term tumour surveillance. Thus, investigating and targeting of proteins at the crossroad of cell death and host defence pathways, such as RIPK1, caspase-8 and IAPs, will provide new therapeutic opportunities in the field of immunotherapy.A Postdoctoral Training Fellow position is available to investigate the regulation of immunogenic cell death in Triple Negative Breast Cancer. The aim of this project is to exploit the complex relationship between cell death and immunology, and harness this to stimulate long-lasting immunological protection and prevent tumour relapse and overcome tumour resistance.The successful candidate will use a series of patient-derived, three-dimensional (3D) tumour organoid (PDOs) models for the assessment of rational-based treatment combinations. In addition to homotypic PDO cultures, he/she will also use 3D heterotypic PDO models composed of tumour cells and immune cells. This will allow the candidate to explore whether the treatment combination triggers immunogenic cell death, and causes immune cell infiltration, activation, and cytotoxicity.You will have the opportunity to interact within a multidisciplinary environment of molecular biologists, clinicians, computer scientists and a network of international collaborators.You should possess a PhD in a biological science such cell biology. Experience with 3D organoid culturing is essential. Experience with genetic engineering of mammalian cells is desirable.Appointment will be on a Fixed Term Contract for 3 years. The full salary scale for the post is in the range from £30,410 to £43,463 p.a. inclusive. Starting salary will be based on previous postdoctoral experience.Informal enquires can be made to Professor Pascal Meier at [email protected] Please do not send your application to Professor Pascal Meier, formal applications must be submitted online. To apply please submit your CV and covering letter (addressing with specific examples where you meet the person specification and incl. the names and addresses of at least two referees) online.

7485| Medical Research Council, Toxicology Unit| RCUK Innovation Fellowships| RCUK Innovation FellowshipsClinical and Non-Clinical Research Training Programme in Toxicology and Clinical PharmacologyMedical Research Council -Toxicology Unit, LeicesterFixed Term up to 31st March 2021Salary: MRC Band 4 £30,162 – £38,545 MRC Band 3 £37,395 - £50,517*Registered clinicians will receive a clinical allowance according to experience (ranging from £1,883 to £14,341)We are pleased to announce the launch of a new Post-Doctoral Fellowship Training Programme suitable for scientists looking for an opportunity to broaden experience and develop cross-disciplinary skills. Six clinical/non-clinical Fellowships are available on this unique, collaborative research training programme, which will provide novel training and research opportunities in fundamental mechanistic toxicology, exposure modelling, exposomics and clinical pharmacology/drug safety. The programme will be jointly administered by three establishments (two Fellows based at each Centre), these will be the MRC Toxicology Unit (MRC-TU Leicester), the MRC Centre for Drug Safety Science (MRC-CDSS, University of Liverpool) and the MRC-Public Health England (PHE) Centre for Environment & Health (MRC-PHE CEH, Imperial College and King’s College London). The scheme brings together combined scientific expertise of staff from the participating Institutions in toxicological, environmental and pharmacology to provide an exciting new framework for research, training and interaction with industry. Each Fellowship will be allocated to a host institution. Projects will be joint between two of the three Centre’s with approximately 3-6 months being spent at the partner Centre, this will ensure that Fellows benefit from the varied working environments and facilities on offer to enable the acquisition of a wide-ranging applied skills set.On completion of a Fellowship, individuals will be highly competitive to apply for Senior Fellowships and establish independent research programmes.Examples of possible projects include studies into toxicities associated with i) nanofibre (e.g. carbon nanotube) exposure (MRC-TU, CEH-PHE), ii) pathways that link sodium excretion, blood pressure and cardiovascular disease (CEH-PHE, MRC-TU), iii) immune check-point inhibitors (CDSS, MRC-TU), iv) alcohol liver disease (CEH-CDSS). The MRC Toxicology Unit is now inviting applications for two Fellowships to this programme. We are looking for highly motivated candidates with considerable experience of innovative molecular research. You must hold a PhD in a relevant discipline and have published in a peer reviewed journal. Experience of molecular toxicology/pharmacology would be a distinct advantage. Please note the Toxicology Unit, located at the University of Leicester, is currently in the process of transferring to the University of Cambridge. Legal transfer will take place in March 2018; the physical relocation is expected to take place in early 2020. Applications should include a CV; contact details of two referees and a one-page proposal describing your research interests.Further information can be found at: http://tox.mrc.ac.uk/*Appointment to MRC Band 3 requires significant relevant postdoctoral experience and evidence of a trajectory towards independence, including an excellent publication record.Funding is immediately available for these positions and applicants must be able to start employment as soon as possible.For full details of this post and to complete an online application, visit https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/705 and upload your CV along with a covering letter. Please quote reference TOX 655.Closing date: 10 October 2017

7489| University College London, Medical Physics and Biomedical Engineering| Research Associate in Histology Reconstruction| Full TimeSalary: UCL Grade 7. £34,635 - £41,864 per annum, inclusive of London AllowanceThis project aims to construct a next-generation computational atlas of the human brain using ex vivo samples (histology, ex vivo MRI), along with companion tools that apply the atlas to the automated segmentation of in vivo scans in neuroimaging studies. The post-holder will develop automated or semi-automated methods for the reconstruction of the histological data, by taking advantage of heterogeneous sources of information (e.g., existing lower-resolution probabilistic atlases, manual segmentation, MRI scans). The post is funded for two years in the first instance. Applicants should have a PhD or equivalent research experience in biomedical analysis; and should have an Upper Second Honour Degree in Computer Science, Engineering or a comparable subject. For further information, please refer to the job description and person specification at the bottom of this page. For further details about the vacancy and how to apply online please go to http://www.ucl.ac.uk/hr/jobs/ and search on Reference Number 1667939For informal queries about the post or project please contact Dr Juan Eugenio Iglesias [email protected] For any queries about the application process please contact Alexandra Ferrell [email protected] Date: 29 September 2017Latest time for the submission of applications: 23.59.UCL Taking Action for EqualityTo apply please click https://atsv7.wcn.co.uk/saf/login.cgi?SID=b3duZXJ0eXBlPWZhaXImb3duZXI9NTA0MTE3OCZleHRlcm5hbD0yMzM3MDcmamNvZGU9MTY2NzkzOQ

7453| THE CANCER RESEARCH UK MANCHESTER INSTITUTE| POSTDOCTORAL SCIENTIST – STEM CELL BIOLOGY - identifying candidate therapeutic targets for potential drug development| •Job Ref: MI/17/56•Commencement of post: January 2018 •Duration of post: 3 years (in first instance)A 3-year position is available for a highly motivated postdoctoral scientist in the laboratory of Professor Georges Lacaud to investigate the roles of the transcription factor RUNX1 and/or the epigenetic factor MOZ in normal haematopoiesis and leukaemia. The successful applicant will use different mouse models already available in the laboratory to identify genes and pathways regulated by these two transcriptional regulators either in normal or malignant haematopoiesis. Their relevance will be evaluated using state-of-the-art mouse models, CRISPR genome editing, ES cell and primary human leukaemia cell cultures. The ultimate goal of this work is to identify candidate therapeutic targets for potential drug development.The successful applicant should have a PhD in molecular or cellular biology. A background in haematopoiesis or leukaemia is desirable but not required. Informal enquiries should be directed to Georges Lacaud ([email protected]).The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire, England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside. We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. The Institute has outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.To apply for this position please visit our website: www.cruk.manchester.ac.uk For applicants who are unable to download this information from our website, please contact HR department on 0161 306 0840, email: [email protected].ac.uk to have this information sent by post.Closing date: 25 September 2017.

1039681| Henry Hill & Associates Inc. (HHAI)| MEDICAL EDUCATION MANAGER (3 positions) - 3045| INDUSTRY SEGMENT: Pharmaceutical DESCRIPTION: Our client, a multinational medical and pharmaceutical manufacturer is experiencing strong growth and are looking for an experienced Medical Education Manager. In this role, you will develop and implement scientific and clinical programs that will facilitate scientific exchange and help advance the knowledge of health care professionals. REQUIREMENTS FOR MEDICAL EDUCATION MANAGER: - Candidates must have: Minimum 5 years of experience in the pharmaceutical industry in a health education or training role Minimum Bachelor of Science Degree - MSc or PhD preferred Experience discussing complex scientific and clinical information with health care professionals Above average communication skills Above average presentation and organizational skills We thank all interested applicants, but only those individuals meeting the above requirements AND submitting via web portals may be considered. Since international travel to the USA and/or other countries may be required, valid documentation is necessary. To ensure your résumé is given processing priority, please include your current city of residence.

1039654| Henry Hill & Associates Inc. (HHAI)| Senior MANAGER, NEW PRODUCTS (Pharma) - 3080| INDUSTRY SEGMENT: Pharmaceuticals DESCRIPTION: Our client, a fast growing pharmaceutical company, is currently searching for a Sr. Manager New Products to lead the commercial assessments of new products in the pharmaceutical industry. Working in close collaboration with your colleagues, you will drive new product business decisions and develop analytical strategies and solutions to optimize overall business performance. REQUIREMENTS FOR SR. MANAGER, NEW PRODUCTS - Candidates must have: Minimum 10 years of progressive pharmaceutical industry experience Minimium 3 years experience in a commercial product development role Bachelor's level degree, advanced Degree preferred (MBA, PhD, MD) In-depth knowledge of Health Canada guidelines and other regulatory requirement High Degree of financial and business acumen Excellent analytical and project management skills with a strong ability to manage multiple priorities We thank all interested applicants, but only those individuals meeting/exceeding the above requirements need apply. Since international travel to the USA and/or other countries may be required, valid documentation is necessary. To ensure your résumé is given processing priority, please include your current city of residence.

7486| University of Nottingham, Mechanical, Materials and Manufacturing Engineering| Postdoctoral Research Associate in Composite Structures and Metamaterials Modelling and Health Monitoring (4 year Fellowship in collaboration with leading European aerospace industries)| Applications are invited for a full-time Postdoctoral Research Associate post within the Composites Group of the University. This is an EU Horizon2020 funded 48 month vacancy. A fixed-term contract will be offered to the successful candidate. Remuneration will depend on previous experience but the appointee should be expecting to receive a salary of £30,000 - £37,000 per annum.The successful candidate will be expected to make significant contributions to the development of multiscale and wave propagation modelling tools for composite structures and complex mechanical and acoustic metamaterials. Applicants should be able to demonstrate a consistent publication track record in the areas of numerical modelling and/or composite structures and/or metamaterials and/or NDE.This funding call is open to all UK, EU and International applicants.Informal enquiries prior to making an application should be addressed along with a detailed CV to Dr D. Chronopoulos [email protected] This position will remain open until filled.

7465| The Institute of Cancer Research, Breast Cancer Research| Postdoctoral Training Fellow (x2) - Cell Death & Inflammation - Mitosis and Cell death| The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally. The Breast Cancer Now Toby Robins Research Centre at the ICR is the first centre in the UK entirely devoted to breast cancer research and its goal is to advance research into the causes, diagnosis and treatment of breast cancer. Formerly known as The Breakthrough Toby Robins Breast Cancer Research Centre, at The Institute of Cancer Research, London, it is located in state-of-the-art laboratory space, with excellent core facilities and funding. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer. The Cell Death and Inflammation Team, led by Professor Pascal Meier, is focussing on the complex relationship between cell death and mitosis, and how this can be exploited to prevent tumour relapse and stimulate long-lasting immunological protection.Cell death and mitosis are ancient processes of fundamental biological importance in both normal physiology and cancer. The recent observation that apoptosis regulatory components have dual roles in cell death and chromosome segregation suggests that these proteins are activated, not just to kill, but to maintain genetic integrity, and replace genetically unstable cells, thus enhancing the resilience of epithelia to insult. This perspective unifies cell death components as positive regulators of chromosome stability and tissue homeostasis.We are seeking Postdoctoral Training Fellows (x2) to investigate how cell death regulatory proteins actively promote faithful chromosome alignment during mitosis, and how they are activated to lethal levels when cells exhibit defects in mitosis progression. We also aim to identify strategies that trigger immunogenic cell death to overcome treatment resistance and provide new therapeutic opportunities in the field of immunotherapy.You will use a series of state-of-the art biochemical, imaging and in vivo approaches to establish the physiological and pathological role of components of the cell death machinery (ripoptosome) in regulating mitosis. This project touches upon many different fields of cancer biology, which will give you the opportunity to learn about the latest approaches in genome editing and explore the relationship between cell death, mitosis, tumour heterogeneity and immunology.You will have the opportunity to interact within a multidisciplinary environment of molecular biologists, clinicians, computer scientists and a network of collaborators who will assist with imaging capabilities, in vivo models for lung cancer, pharmacological lung cancer and biomarker studies, immunotherapy, and mass spectrometry.You should possess a PhD in a biological science such as genetics, cell biology or biochemistry. Experience in mitosis and/or genome instability is desirable. Experience with genetic engineering of mammalian cells or in vivo work is desirable.Appointment will be on a Fixed Term Contract for 3 years. The full salary scale for the post is in the range from £30,410 to £43,463 p.a. inclusive. Starting salary will be based on postdoctoral experience.Informal enquires can be made to Professor Pascal Meier at [email protected] Please do not send your application to Professor Pascal Meier, formal applications must be submitted online. To apply please submit your CV and covering letter (addressing with specific examples where you meet the person specification and incl. the names and addresses of at least two referees) online.