8214| LMU Munich, Center for NanoScience| Single Molecule Mechanics of Cell Adhesion| Project: Adhesion of Cells to Substrates is essential for all multi-cellular life. In this project, you will study the binding mechanics and the mechanical signaling of Integrin receptors in single molecule experiments using a combination of optical tweezers and fluorescence microscopy. The aim is to unravel the mechanisms of how mechanical forces are transmitted from the inside to the outside. This work is embedded in a highly interdisciplinary project between physicists and cell biologists funded by the ERC.Requirements: A background in biophysics/biochemistry is required. Depending on your specific background the work will be more biochemical or physical. However, you should be willing to learn and adopt new methods and like work in an interdisciplinary environment. Please note tht only online applications via the CeNS application website will be accepted.

8218| LMU Munich, Center for NanoScience| Postdoc in Biophysics: Emergence of Replication on early Earth| We will reconstruct in the lab the first cycles of Darwinian evolution. Our bottom up approach reconstructs the boundary conditions of early Earth to gather and drive the first living molecules. We will focus on persistent replication, emergence of a phenotype and selection to overcome central hurdles in our understanding of the origins of life. The approach can be compared to an engineer who designs a chemical plant to implement a specific chemical reaction. We will aim for conditions under which these genetic molecules can polymerize efficiently to oligonucleotides of sufficient length and trigger the initial replication cycles. They include temperature gradients, water-air interfaces, crystallization and gelation processes at the micrometer scale. We aim to create a self-selection of random sequences into a phenotype of sequence-similar chirally pure RNA or DNA molecules.Requirements: An independent mind with practical skills and a broad background from physics, biophysics, physical chemistry, biochemistry and chemistry would be most desired.Position/Salary: TV-ÖD E13 100%, 2 years with extension to 3 years.Group: Prof. Dieter Braun, Faculty of Physics, Systems Biophysics, LMU Munich Please apply via the online application tool of the Center for NanoScience. Other forms of application will not be accepted.

8185| University of Otago, Department of Chemistry| Postdoctoral Research Fellow – Synthesis of Carbon-rich Molecular Materials| New carbon-rich molecular materials, based on well-defined nanographenes and other novel polyaromatic architectures, will be rationally synthesised to better understand structure-property relationships. Of particular interest is the tuning of electronic/optical properties, and exploring the correlation between molecular and bulk structure towards porous organic frameworks for uptake/storage of gases and other guests. The project involves a major component of organic synthesis, combined with characterisation of the structure and properties of resultant materials, both in-house and with collaborators within the MacDiarmid Institute for Advanced Materials and Nanotechnology. A successful applicant will have a PhD in chemistry, an excellent command of written and spoken English, and research outputs including in top chemistry journals. Knowledge and experience in organic/organometallic synthesis, purification, and characterisation techniques such as NMR is essential. The tenure of the postdoctoral position is 1–2 years, and it is desired that a successful candidate will take up the position as soon as possible. Review of applications will continue until the position is filled. Applications should include a full CV and the names/contact details of at least two referees. Applications should be sent (preferably by email) to: Assoc. Prof. Nigel Lucas, Department of Chemistry, University of Otago, PO Box 56, Dunedin, New Zealand; [email protected]

8181| Technical University of Denmark| Postdoc in Pervasive Health Technology for Diabetes Management| The Copenhagen Center for Health Technology (CACHET) is looking for a post-doctoral researcher within pervasive healthcare technology for diabetes management. You will have a central role in designing novel interactive and ubiquitous diabetes management technology to be used in clinical trials. You will be part of a large European project with academic and commercial partners. CACHET [www.cachet.dk] is a strategic research partnership between the Capital Region of Denmark, the City of Copenhagen, the Medical and Health Faculty at the University of Copenhagen, and the Technical University of Denmark (DTU). We carry out many different research projects together with our academic, clinical, and industrial partners. Your work will be part of the technological research in CACHET, which is carried out at the DTU Department of Health Technology and the DTU Department of Applied Mathematics and Computer Science. You will be part of a team of computer science researchers, postdocs, PhD students, and programmers at DTU. Responsibilities and tasksAs a post doc in CACHET you will lead and work within a team of researchers and software engineers in designing and developing technology for data collection, management, and visualization for diabetes management. As part of this team, your role will be to; • lead and manage the user-centered design process in close cooperation with patients, clinicians, care workers, and the academic and commercial partners in the project• survey existing interactive and pervasive health technologies for diabetes management• be responsible for the design of a novel patient-centric technological solution for diabetes management and lead the development of it as part of the team• be the technical responsible during the clinical trial• lead the publication of academic papers on the research done CACHET is an interdisciplinary research center and you will be working with; • technical researchers focusing on algorithms and approaches for health data analysis, software architectures for collection and management of health data, sensor and wearable technology, and the design of end-user applications for mobile health (mHealth)• clinical researchers, medical doctors, nurses, community care workers, and end-users in the design of diabetes tools to be used in clinical practice. A key role will be to work as the project manager for the technological design, implementation, and evaluation. QualificationsWe are looking for a candidate with a PhD in computer science or computer engineering with a strong research track record and experience in one or more of the following research areas: • human-computer interaction & UX design• ubiquitous computing • mobile, wearable, and pervasive health applications• software engineering and software architecture In addition, you have: • a strong background in design science, including human-computer interaction and UX design• solid technological skills with a demonstrated portfolio of software and/or hardware development experience• strong analytical and academic skills • compelling oral and written communication skills in English with a track record of scientific publications, conference presentations, reports and/or popular dissemination• experience in teaching and supervision of students at an academic level• the ability to work in an international academic setting with a variety of different colleagues and partners, including the ability to travel internationally for meetings• project management experience e.g. from your Ph.D. project We offerDTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. In CACHET we work as a close team in an open research spirit, where we share good as well as bad ideas for mutual inspiration and support. Salary and terms of employmentThe appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is from February 1, 2019 or as soon as possible to December 31, 2021. The workplace will be DTU Lyngby Campus. The position is a full-time position. You can read more about career paths at DTU here: http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths Further information Further information may be obtained from Professor Jakob E. Bardram, [email protected] You can read more about CACHET at www.cachet.dk and DTU at www.dtu.dk Application procedure Please submit your online application no later than 31 December 2018 (local time). Apply online at www.career.dtu.dk. Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include: • Application (cover letter)• CV• Diploma (MSc & PhD)• List of publications • List of teaching and supervision experience• List of technologies / applications Applications and enclosures received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

8189| Imperial College London, Department of Life Sciences| Postdoctoral Research Associate| The Department of Life Sciences was the top ranked university department in the UK for research intensity in Biological Sciences in REF2014 Times Higher Education, scoring 100% on our environment.A Research Associate position is available to join the laboratory of Professor Gloria Rudenko in the Department of Life Sciences based at the South Kensington Campus of Imperial College London.The research programme investigates the molecular biology of African trypanosomes, particularly with regards to the epigenetic control of gene expression. Trypanosomes provide an experimentally amenable system for investigating transcriptional control in an early branching eukaryote. Trypanosomes are single-celled eukaryotes which are protected by a dense Variant Surface Glycoprotein (VSG) coat. Each trypanosome encodes hundreds of VSG coats, but only one VSG gene is transcribed at a time. The active VSG is located in one of about 15 telomeric VSG expression site transcription units. Trypanosomes can continuously switch between transcription of different VSG expression sites.We would like to understand how this singular expression of one VSG gene at a time is controlled. How are VSG expression sites turned on and off, and how is their mono-allelic expression controlled? We would like to investigate the role of epigenetic mechanisms. These include chromatin structure, epigenetic marks and nuclear positioning. Expression sites are always telomeric. What is the role of genomic architecture? Hopefully the candidate will help us answer these questions and elucidate how these variant surface genes are controlled. Additional information about our research programme is available on our lab website: http://rudenkolab.co.uk/. Duties and responsibilitiesTo acquire and interpret research data and take initiative in the planning of researchTo maintain accurate and complete records of all findingsTo present findings to colleagues and at conferencesFunction independently as a research scientist with the ability to take initiative.Supervise the work of undergraduate and postgraduate studentsDraft publications and prepare them for submission to refereed journals.Essential requirementsA Undergraduate degree in Molecular BiologyA PhD (or equivalent) in Molecular BiologyYou must be able to demonstrate the following:Experience in investigating the mechanistic molecular biology of any experimental system.Interest in and preferably experience in investigating transcriptional control.Experience in a broad range of molecular biology techniques including: sterile cell culture and transfection, DNA cloning, Nucleic acid and protein analysis, PCR, qPCR, immunofluorescence microscopyThe ability to develop and apply new concepts and have a creative approach to problem-solving.Excellent verbal and written communication skillsAn ability to organise your own work with minimal supervision.Further informationAny candidate who has not been yet been awarded their PhD, will be appointed as a Research Assistant within the salary range £33,380 - £35,061 per annum. This is a full time, fixed term position for two years.For informal enquiries, please contact Professor Gloria Rudenko via email at [email protected] .Should you have any queries about the application process, contact Peggy Baker by email at [email protected] and refer to the job reference number NAT00311.For technical queries when applying online, contact [email protected] .The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

8207| Liverpool School of Tropical Medicine| Post-Doctoral Research Associate: Centre for Snakebite Research & Interventions| Post-Doctoral Research Associate (Ref: 526-18) Centre for Snakebite Research & InterventionsDepartment of ParasitologySalary: £34,189 to £39,609 per annumFull-time, Fixed-term appointment until 31st March 2021 (with the possibility of extension)Based in Liverpool Founded in 1898 and the oldest of its kind in the world, the Liverpool School of Tropical Medicine (LSTM) is an internationally recognised centre of excellence for teaching and research in tropical diseases. Through the creation of effective links with governments, NGOs, private organisations and global institutions and by responding to the health needs of communities, LSTM aims to promote improved health, particularly for people of the less developed/resource poorest countries in the tropics and sub-tropics.The Centre for Snakebite Research and Interventions (CSRI) at LSTM is at the forefront of research to develop the next generation of snakebite therapies. The intent is to develop therapies with unparalleled efficacy, affordability and safety – to substantially and sustainably reduce the high rates of deaths and disability that currently afflict snakebite victims throughout the world. The CSRI is currently recruiting a Post-Doctoral Research Associate (PDRA) to be part of a substantial, multi-disciplinary research team dedicated to identifying and implementing systems and tools to improve the treatment of tropical snakebite. As part of the project, you will lead, design and establish in-house scientific expertise to develop recombinant human/humanised antibodies as candidates as new snakebite-treatment tools, as well as refine the efficacy-selection and refinement of those monoclonal antibodies. The PDRA will supervise and develop under-graduate and post-graduate students whilst contributing to teaching at LSTM. You will actively participate in the CSRI’s engagement tasks and help incorporate results of this research into the project’s other biotherapeutic and socioeconomic results for delivery as academic publications. Another key element of the post will be your contribution to the writing of bids for research grants.It is essential to hold a PhD in a relevant field with evidence of continuous professional development and have knowledge of antibody engineering and a range of molecular and immunological techniques. Demonstrable experience in generating and selecting monoclonal antibodies is a highly desirable characteristic, and any practical skills and knowledge of venom biology or venom therapeutics will be an added advantage. As a member of a diverse team, your ability to liaise effectively with collaborators and team members from different cultures is vital. Though based in Liverpool, you must be willing and able to travel to USA, Africa and India for research collaboration and training visits.Closing Date: 13th January 2019Please note: LSTM will close on 19th December 2018 and will not re-open until 2nd January 2019. We will be unable to respond to any queries during this period.Take a look at some of the great work we have achieved over the past year 2017-2018 by viewing our annual report: https://www.lstmed.ac.uk/about/publications/lstm-annual-report-2017-2018We believe that this post will not be suitable for individuals on Tier 5 visas as these posts are not considered to be supernumerary to the organisation. For further details, please visit the UKVI website: https://www.gov.uk/browse/visas-immigration/work-visas LSTM actively promotes Equal Opportunities and Safeguarding Policies

8222| US air Force academy, LSRC/Dept Biology| Post-Doc/Visiting Researcher| NRC Post-doc/Visiting Researcher, Life Sciences Research Center US Air Force AcademyTo work with a team investigating the unique properties of microbial photosynthetic extremophiles and developping novel genetic engineering systems for these organisms. Description and BackgroundThe Life Sciences Research Center’s (LSRC) primary mission is to support the Air Force’s research programs at the Air Force Office of Scientific Research (AFOSR) and Air Force Research Laboratories (AFRL) through faculty and cadet research efforts. The center is focused on discovering and understanding basic mechanisms used by photosynthetic microorganisms to transfer energy and survive in extreme environments, and on developing methods to make them tractable to genetic manipulation. Comparing the genetic basis of these mechanisms across different species and/or environments may reveal potential foci for genetic engineering of designer organisms with increased growth tolerances and/or metabolic efficiency. These research thrusts have applications for the U.S. Air Force ranging from protein stability under harsh conditions to energy transfer across biotic/abiotic interfaces to the development of biosensors for threat detection and mitigation. ReferencesHallenbeck PC et al. Draft Genome Sequence of a Thermophilic Cyanobacterium from the Family Oscillatoriales (Strain MTP1) from the Chalk River, Colorado, Genome Announcements, 4 (2016) e01571-01515. Hallenbeck PC et al. M. Grogger, M. Mraz, D. Veverka, Draft Genome Sequence of the Photoheterotrophic Chloracidobacterium thermophilum Strain OC1 Found in a Mat at Ojo Caliente, Genome Announcements, 4 (2016) e01570-01515. Hallenbeck, PC et al. M. Grogger, D. Veverka, Recent Advances in Microbial Electrocatalysis, Electrocatalysis, 5 (2014) 319-329.QualificationsApplications are encouraged from individuals with a background in phycology, microbiology, biochemistry, extremophile physiology, electrochemistry, DNA sequence analysis, bioinformatic platforms or genetic engineering, and experience with thermophiles, psychrophiles, microbial fuel cells (MFCs), desiccation tolerant organisms, including desert crust microbiota, isolation and identification of photosynthetic microorganisms, and developing methods for exogenous protein expression in algae or cyanobacteria. How to ApplyThe United States Air Force Academy (USAFA) participates in the National Research Council Research Associateship Program, sponsored by the Air Force Office of Scientific Research.New openings are available and the specifics as well as application process can be accessed here: (http://sites.nationalacademies.org/pga/rap/)Some important notes for the interested applicant:1) Must be a US citizen or green card holder2) Experience and research background must align with our research as closely as possible3) The NRC-RAP program is highly competitive, pays salary, travel and relocation expenses for one year with option to extend for an additional year depending on research productivity.4) Applications run year round with application periods running each quarter (e.g., on-line application period is currently open with a subsequent application deadline of 1 February 2019)5) Thus opportunity is under “Air Force Research Labs (AFRL), click at the top link, then move to left hand links for “search opportunities”, put in my last name “Veverka” or “Extremophiles” for keyword and our opportunity should pop-up (13.04.05.B8432).6) Click on the “apply now” link to start the process.

8204| University of Edinburgh, School of Biological Sciences| Metabolic Specialist| This is an excellent opportunity for you to apply your expertise towards running a metabolomics platform dedicated to metabolite analysis from synthetic biological constructs within the UK Centre for Mammalian Synthetic Biology (www.synbio.ed.ac.uk). You will use your expertise in high-resolution mass spectrometry to establish a high-throughput pipeline for both targeted and discovery mode analysis of various metabolite classes from host chassis, working with principal investigators across the Centre and the wider University. You will bring solid experience in liquid and gas chromatography/mass spectrometry and associated data analysis, statistics and sample preparation evidenced by being lead author on publications in the area. Ideally, you will bring experience of the following: Metabolomics, statistical analysis of large data sets, HPLC/Orbitrap, Thermo Fisher LC/MS, GC/MS and R.Applicants should have a PhD in Chemistry, Biochemistry or a related biological discipline with at least 2 years postdoctoral experience and ideally 4 years of working in metabolomics. The position involves working in a multidisciplinary environment and the candidate should have excellent communication and organisation skills, the ability to take initiative and the ability to work flexibly either in a group or independently.This post is available until 13 November 2020 with the potential for extensionClosing date: 03 January 2018Salary range: £40,792 - £48,677Vacancy reference: 046142To apply please click the link below:https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=046142

8216| LMU Munich, Center for NanoScience| Postdoc position: Custom-tailored photonic crystals| Project: The optical functionality of photonic crystals originates from the interaction of light with the differential refractive indices of the surrounding media and the structured material. Plasmonic photonic crystals additionally exploit the strong dipole polarisibility of the collective electron-density fluctuations of incorporated metal particles. The goal of this project is to exploit the combination of bottom-up with top-down methods for the design and fabrication of materials with tailored optical properties.Requirements: The candidate is expected to have a strong background in physics or chemistry. Experience in optics, spectroscopy and / or lithography techniques will be extremely beneficial.Position/SalaryTV-ÖD E13, Project duration: 4 yearsGroup: Prof. Tim Liedl, Molecular Self-Assembly and Nanoengineering, Physics Department, LMU MunichPlease note tht only online applications via the CeNS application website will be accepted!

8199| University of Turin - Candiolo Cancer Institute, Departmemnt of Oncology| junior Postdoctoral Research Fellow| A junior Postdoctoral Research Fellow position is available at the Candiolo Cancer Institute to identify novel therapeutic strategies for colorectal cancer. This is a one year full-time position funded by a grant from Associazione Italiana per la Ricerca sul Cancro (AIRC, PI: Dr Claudio Isella, PhD).The limited efficacy of targeted therapies on colorectal cancer (CRC) has been ascribed to two main factors: first, the complexity of molecular heterogeneity across tumours despite the same tissue of origin, leading to variable response in different patients; second, intratumoural heterogeneity, typically associated with worse prognosis and treatment resistance. More recently, we observed that about a quarter of CRCs is endowed with high stromal cells content and poor prognosis. To date, however, systematic exploration of potentially actionable paracrine activities occurring between stromal cells and epithelial cells in CRC is still missing.We aim at the systematic characterization of tumour-stroma interplay in CRC, to provide a new rationale for prognostic and therapeutic stratification. To tackle this issue, we are planning to employ genomic analysis of a collection of patient-derived preclinical models of CRC, including the Institute’s archive of more than 1000 patient-derived xenografts, and over 151 CRC cell lines cultured in vitro and propagated in vivo by xenografting.Applicants should have a PhD in computational biology, bioinformatics or cancer biology, with skills in RNAseq data processing and analysis, database interrogation, R language scripting. Previous experience in the field of cancer (computational) biology is preferable. Excellent communication skills and ability to work in team are required. The successful applicant will be involved in an international and collaborative working environment (working language: English) and will join a dynamic and multidisciplinary group at the Candiolo Cancer Institute, a renowned and fully equipped with state-of-art core facilities cancer Center in Northern Italy with strong ties with the University of Torino Medical School and many documented national and international collaborations (see for more details: www.ircc.it/irccit).Applications should be submitted by November 10, 2018 to [email protected] and should include a CV with a list of publications, reprints of at least two peer-reviewed articles, a research statement, a cover letter and contact information for at least two referees.References1-Isella et al, Nature Genetics 20152-Isella et al Nature Communication 2017 3-Isella et al, Ann of Surgery 20154-Bertotti et al, Cancer Discovery 2011 5-Medico et al, Nature Communication 2015 6-Isella et al, BMC bioinformatics 2011

8184| Medical Research Council, Laboratory of Molecular Biology| Postdoctoral Scientist - Cell Biology - Mark Skehel - LMB 970| Postdoctoral Scientist – Cell BiologyStarting Salary - £30,464 - £33,305 per annum3 year fixed term positionMRC Laboratory of Molecular Biology, Cambridge, UKThe Biological Mass Spectrometry & Proteomics facility at the MRC Laboratory of Molecular Biology (LMB) seeks a bioinformatician/computational biologist to join their team. The lab aims to cover all aspects of protein mass spectrometry and is set up primarily to use a ‘bottom up’ peptide centric approach for protein identification, quantification (SILAC, isobaric labelling, label free) and the discovery, characterisation and quantification of post-translational modifications. In addition, the facility has a strong focus on structural proteomics, concentrating specifically on chemical cross-linking and hydrogen/deuterium exchange-mass spectrometry. You will supply bioinformatics support to scientists in both the Facility and LMB, focusing on experimental design and the provision of specialist data analysis for a number of -omics data types.Candidates should have a PhD or DPhil in a relevant subject and a background in bioinformatics, biology or computational science. An understanding of protein mass spectrometry and proteomics is also required.The successful applicant will be awarded a three year Career Development Fellowship / Postdoctoral training Scheme position. This is a training and development position for a post-doctoral scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org.Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/appcentre-ext/candidate/post/2026/en-GB.If you are unable to apply online please contact us at [email protected] date: 16/12/18Final appointments will be subject to a pre-employment screening.The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme.

8203| Agri-Food and Biosciences Institute Northern Ireland (AFBI)| ECONOMIST – ALICE PROJECT – 22 MONTH FIXED TERM CONTRACT| This project has been supported by the EU’s INTERREG VA Programme, managed by the Special EU Programmes Body (SEUPB).An exciting opportunity to work as part of the interreg project ALICE within AFBI-Economics, contributing to the development of a Payment for Ecosystem Services scheme for Northern Ireland/Republic of Ireland, France, Spain and Portugal.Further appointments may be made from this competition should AFBI positions become vacant which have similar duties and responsibilities.For more detailed information and to apply, please go to www.nicsrecruitment.org.ukAlternatively, an application pack can be requested by contacting:HRConnect, PO Box 1089, The Metro Building, 6-9 Donegall Square South, Belfast, BT1 9EW. Telephone: 0800 1 300 330. Email: [email protected] requests must include your name, address and reference number IRC234391Completed application forms must be returned to arrive not later than 12:00 noon (UK time) on Wednesday 2nd January 2019Applications are particularly welcomed from Roman Catholics and Females as these groups are currently under-represented within AFBI.AFBI is an Equal Opportunities EmployerALL APPLICATIONS FOR EMPLOYMENT ARE CONSIDERED STRICTLY ON THE BASIS OF MERIT

8227| Austrian Academy of Sciences, Research Center for Molecular Medicine| Postdoc Position: Technology-driven Research in Biomedicine| We are recruiting an ambitious postdoc who wants to develop and apply cutting-edge technology for biomedical research and for advancing diagnostics/therapy in cancer and other diseases. Key areas of interest include cell-based therapy (CAR T and beyond), sequencing technology, CRISPR editing/screening, advanced microscopy, targeted drug delivery, advanced antibody/aptamer therapeutics, systems immunology, and synthetic biology.Our group at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna combines wet-lab biology (epigenomics, single-cell sequencing, drugs & CRISPR screening, imaging, etc.) with bioinformatics and artificial intelligence. We work closely with physicians at the Medical University of Vienna to advance precision medicine.The ProjectThese are exciting times for technology-driven research in biomedicine, with many opportunities for breakthrough technologies. We are broadly interested in technology development that combine e.g., wet-lab and computational methods, sequencing and imaging, diagnostics and devices, small molecules and biologicals, synthetic biology and cell-based therapies. If you have a project in mind, we would be happy to discuss. If not, here are a few potential directions: (i) CRISPR single-cell sequencing: Building upon our CROP-seq technology (Datlinger et al. 2017 Nature Methods), we develop assays for massive-scale functional biology. (ii) Synthetic cancer biology: We use (epi-)genome editing to build artificial cancer cells and engineer killer cells that specifically destroy dangerous cells. (iii) Droplet devices: We are interested in scalable microfluidics that combine drugs, imaging, and sequencing; (iv) Targeted delivery: We explore new ways to deliver CRISPR in vivo to the right cells.The CandidateWe are looking for candidates who want to pursue groundbreaking research and advance their scientific career. A typical background could be in molecular biology, biomedical research, bioengineering, or related areas (cell-based therapies, functional genomics, etc.). A keen interest in interdisciplinary collaboration is a plus. We are fully equipped and experienced with wet-lab and computational work, allowing candidates to get the best of both worlds and establish a unique skill set that will allow them to combine both wet-lab and bioinformatics in their future lab.The Lab (http://epigenomics.cemm.oeaw.ac.at/)The Medical Epigenomics Lab at CeMM pursues an interdisciplinary and highly collaborative research program aimed at understanding the cancer epigenome and establishing its utility for precision medicine. The lab is internationally well-connected and active in several fields:• Epigenomics. Many diseases show widespread deregulation of epigenetic cell states. As members of the Human Cell Atlas and the International Human Epigenome Consortium, we use epigenome sequencing to dissect the epigenetic basis of cancer and immunity.• Technology. Groundbreaking biomedical research is often driven by new technologies. Our lab is therefore heavily invested into technology development, including single-cell sequencing, CRISPR screens, and epigenome editing.• Bioinformatics. New algorithms and advanced computational methods allow us to infer epigenetic cell states from large datasets, in order to reconstruct the epigenetic landscape of cellular differentiation and complex diseases.• Diagnostics. New technologies (genome sequencing, mobile devices, etc.) provide important information for personalized medicine. We develop and validate assays and algorithms for translating the value of digital medicine into routine clinical practice.The Principal Investigator (https://scholar.google.com/citations?user=9qSsTcIAAAAJ)Christoph Bock is a principal investigator at CeMM. His research focuses on epigenetics, bioinformatics, and high-throughput technology (single-cell sequencing, CRISPR) in the context of personalized medicine. He is also a guest professor at the Medical University of Vienna, scientific coordinator of the Biomedical Sequencing Facility at CeMM, and adjunct group leader for bioinformatics at the Max Planck Institute for Informatics. He has been a principal investigator of the BLUEPRINT project (in the International Human Epigenome Consortium), and he co-founded Genom Austria, a citizen science project that is the Austrian partner in the International Network of Personal Genome Projects. He is a member of the Young Academy of the Austrian Academy of Sciences (since 2017) and recipient of several major research awards, including the Max Planck Society’s Otto Hahn Medal (2009), a New Frontier Group grant by the Austrian Academy of Sciences (2015-2020), an ERC Starting Grant (2016-2021), and the Overton Prize of the International Society of Computational Biology (2017).The Institute (http://www.cemm.at/)CeMM is an international research institute of the Austrian Academy of Sciences and a founding member of EU-LIFE. It has an outstanding track record of top-notch science (last few years: >10 papers in Nature/Cell/Science/NEJM, >25 papers in Nature/Cell sister journals) and medical translation. With just over a hundred researchers, CeMM provides a truly collaborative and personal environment, while maintaining critical mass and all relevant technologies. Research at CeMM focuses on cancer, inflammation, and immune disorders. CeMM is located at the center of one of the largest medical campuses in Europe, within walking distance of Vienna’s historical city center. A study by “The Scientist” placed CeMM among the top-5 best places to work in academia world-wide (http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012). Vienna is frequently ranked the world’s best city to live. It is a United Nations city with a large English-speaking community. The official language at CeMM is English, and more than 40 different nationalities are represented at the institute. CeMM promotes equal opportunity and harbors a mix of different talents, backgrounds, competences, and interests. Postdocs at CeMM are paid according to the Austrian Science Fund’s salary scheme, which amounts to an annual gross salary slightly above EUR 50,000.Please apply online (https://cemm.jobbase.io/job/o3e97zc9) with cover letter, CV, academic transcripts, and contact details of three referees. Applications will be reviewed on a rolling basis. Any application received by 21 January 2019 will be considered. Start dates are flexible.

8217| LMU Munich, Center for NanoScience| Postdoc position: Organic photocells| Project: Organic photocells are expected to play an important role in the development of cost-efficient photovoltaic panels. By combining bottom-up with top-down methods for the development of new types of organic solar cells, we aim to improve our understanding of charge carrier migration and charge separation and ultimately boost energy conversion efficiencies. The possibility to position multiple components with high accuracy will further allow us to incorporate several donor molecules at once, covering a wider spectrum. Requirements: The candidate is expected to have a strong background in physics or chemistry. Experience in spectroscopy, molecular chemistry and / or lithography techniques will be extremely beneficial.Position/SalaryTV-ÖD E13, Project duration: 4 yearsGroup: Prof. Tim Liedl, Molecular Self-Assembly and Nanoengineering, Physics Department, LMU MunichPlease apply via the online application tool of the Center for NanoScience. Other forms of application will not be accepted.

8191| Austrian Academy of Sciences, Research Center for Molecular Medicine| Postdoc: Bioinformatics, Cancer Genomics, Epigenomics, Precision Medicine| We are recruiting an ambitious computational postdoc who wants to pursue groundbreaking research in bioinformatics and its applications in cancer research, including data analysis and methods development in the areas of genomics, epigenomics, and precision medicine. Our group at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna combines wet-lab biology/medicine including massive-scale data production (cancer genomes/epigenomes, single-cell sequencing, CRISPR screens) with advanced bioinformatics including data science algorithms and deep learning. We work closely with physicians at the Vienna General Hospital & Medical University of Vienna to advance cancer therapy by precision medicine.The ProjectOur lab has pioneered the combined use of high-throughput epigenomics and advanced computational methods for dissecting the epigenetic basis of cancer, toward the goal of enabling new approaches to precision medicine (Nature Reviews Cancer 2012 - https://www.nature.com/articles/nrc3297). In recent projects, we have connected epigenome and clinical imaging data for brain tumor progression (Nature Medicine 2018 - https://www.nature.com/articles/s41591-018-0156-x), investigated epigenetic heterogeneity in a cancer of childhood (Nature Medicine 2017 - https://www.nature.com/articles/nm.4273), identified clinically predictive chromatin signatures in leukemia (Nature Communications 2016 - https://www.nature.com/articles/ncomms11938), and modeled the time series dynamics in leukemia response to therapy (paper in revision). All four papers were spearheaded and first-authored by bioinformaticians. Furthermore, we have developed technology that enables large-scale functional dissection using CRISPR single-cell sequencing (Nature Methods 2017 - https://www.nature.com/articles/nmeth.4177) and drug screening (Nature Chemical Biology, in press). In ongoing and future work, for which the successful candidate will play a leading role, we are studying cancer immunotherapies, the tumor microenvironment, and time series of therapy response.The CandidateWe are looking for ambitious candidates who want to build a scientific career in bioinformatics and/or data science research with applications in biology and medicine. Candidate should have a strong background in the quantitative sciences (computer science, bioinformatics, statistics, mathematics physics, engineering, etc.). We will also consider applicants with a background in biology or medicine who have strong quantitative skills (including programming) and a keen interest in pursuing computational projects (a combination with wet-lab research is possible).The Lab (http://epigenomics.cemm.oeaw.ac.at/)The Medical Epigenomics Lab at CeMM pursues an interdisciplinary and highly collaborative research program aimed at understanding the cancer epigenome and establishing its utility for precision medicine. The lab is internationally well connected and active in several fields: Bioinformatics. New computational methods enable the high-throughput analysis of disease mechanism and therapy responses. We develop algorithms for multi-omics data analysis, time series modeling, and clinical data integration. Epigenomics. Many diseases show deregulation of epigenetic cell states. As members of the Human Cell Atlas and the International Human Epigenome Consortium, we use epigenome sequencing to dissect the epigenetic basis of cancer and immunity. Technology. Groundbreaking biomedical research is frequently driven by new technologies. Our lab is therefore heavily invested into technology development, including single-cell sequencing, CRISPR screens, and deep neural networks. Digital Medicine. New technologies in the area of genomics, imaging, and wearable sensors transform medicine into a ‘big data’ science. We employ machine learning / artificial intelligence to leverage such data for better patient care.The Principal Investigator (https://scholar.google.com/citations?user=9qSsTcIAAAAJ)Christoph Bock is a principal investigator at CeMM. His research focuses on bioinformatics, epigenetics, cancer biology, and high-throughput technology development. He is also a guest professor at the Medical University of Vienna, scientific coordinator of the Biomedical Sequencing Facility at CeMM, and adjunct group leader for bioinformatics at the Max Planck Institute for Informatics. He is a member of the Young Academy of the Austrian Academy of Sciences (since 2017) and recipient of several major research awards, including the Max Planck Society’s Otto Hahn Medal (2009), an ERC Starting Grant (2016-2021), and the Overton Prize of the International Society of Computational Biology (2017).The Institute (http://www.cemm.at/)CeMM is an international research institute of the Austrian Academy of Sciences and a founding member of EU-LIFE. It has an outstanding track record of top-notch science (last few years: >10 papers in Nature/Cell/Science/NEJM, >25 papers in Nature/Cell sister journals) and medical translation. With just over a hundred researchers, CeMM provides a truly collaborative and personal environment, while maintaining critical mass and all relevant technologies. Research at CeMM focuses on cancer, inflammation, and immune disorders. CeMM is located at the center of one of the largest medical campuses in Europe, within walking distance of Vienna’s historical city center. A study by “The Scientist” placed CeMM among the top-5 best places to work in academia world-wide (http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012). Vienna is frequently ranked the world’s best city to live. It is a United Nations city with a large English-speaking community. The official language at CeMM is English, and more than 40 different nationalities are represented at the institute. CeMM promotes equalopportunity and harbors a mix of different talents, backgrounds, competences, and interests. Postdocs at CeMM are paid according to the Austrian Science Fund’s salary scheme, which amounts to an annual gross salary slightly above EUR 50,000.Please apply online (https://cemm.jobbase.io/job/6c6xaqal) with cover letter, CV, academic transcripts, and contact details of three referees. Applications will be reviewed on a rolling basis. Any application received by 10 January 2019 will be considered. Start dates are flexible.

8188| INRA Rennes| Postdoctoral Researcher position in plant-aphid interactions| Applications are invited for a Postdoctoral Researcher to join the research team Ecology and Genetics of Insects (EGI) to study plant-aphid interactions at INRA Rennes. The position is supported by a grant from the French National Research Agency and available from April 2019 for 24 months. A postdoctoral researcher is required to undertake an innovative research project to understand the molecular mechanisms of host plant adaptation in the pea aphid complex. The postdoctoral researcher will conduct identification and functional characterization of aphid saliva proteins that are involved in host plant adaptation. S/he will take full advantage of the resources available in the host research institute, which include excellent research facility, genomics, transcriptomics and proteomics data of the pea aphid complex, extensive live aphid collection and technical and intellectual support from technicians and scientists in the team. Highly motivated individuals with a PhD degree having a strong background in molecular biology and genetics are encouraged to apply. Previous experience with plant-pathogen/insect interactions, in particular, pathogen effectors, yeast two-hybrid screening and tissue culture skills would be highly desirable. Experiences in large-scale dataset analysis through the use of programming languages would be a plus. To apply for the position, please combine cover letter, CV, brief summary of previous research experience (max 1 page) and names and contact information of three referees in one PDF file and send it to [email protected] The closing date for applications will be 15th December 2018 and interviews will be planned in January 2019.

8183| Université libre de Bruxelles (ULB) & Université de Mons (UMONS)| Postdoctoral position in Developmental Neurobiology| We are seeking highly motivated candidates to join us on a project beginning in 2019 on the molecular mechanisms of sensory neurogenesis. We study in particular the nociceptors, the specialized peripheral neurons that detect painful stimuli. We aim to understand the role and mechanism of action of the Prdm12 gene. Prdm12 encodes an evolutionarily conserved epigenetic regulator of gene expression that has been found mutated in patients that suffer from a rare disease, Congenital Insensitivity to Pain, a dangerous condition that renders individuals completely unable to feel pain since their birth (Chen et al., Nat. Genet., 2015). To understand the molecular mechanisms that cause the painlessness, we are using the frog embryo and have generated Prdm12 null and conditional knock-out mouse models. We expect that the results of our work using these experimental systems as well as the identification of Prdm12 direct targets and interacting partners will help in the development of new strategies for treating pain.The positions are funded by the Walloon government within the frame of the “Win2wal” program. They are open from 2 to 4 years and starting dates are flexible. The research will be performed in the laboratory of Developmental Genetics (Dr. Eric Bellefroid, http://gendev.ulb.ac.be/bellefroidlab/) that is part of the University of Brussels (ULB) Neuroscience Institute (UNI), the ULB Structural Biology and Biophysic laboratory (Dr. Abel Garcia-Pino, https://www.cm2ulb.be/) and the laboratory of Neuroscience (Dr. Laurence Ris, https://sharepoint1.umons.ac.be/FR/universite/facultes/fmp/services/neurosci/Pages/Equipe.aspx) at the University of Mons. Preference will be given to applicants with a background in one of the following: mouse genetics, electrophysiology, cell and molecular biology and genome wide approaches (ChIP-seq,…). Interested candidates should send a letter of motivation describing past research experiences and full CV to: Eric Bellefroid ([email protected]), Laurence Ris ([email protected]) or Abel Garcia Pino ([email protected]) together with the name and e-mail address of 2 references.Selected related publications:Thelie et al., (2015). Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Development, 142(19), 3416-3428. Nagy et al., (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle, 14(12), 1799-1808.

8192| Tyndall National Institute| Postdoctoral researcher in Photonics - Lasers for Optical Coherence Tomography| Tyndall National Institute at University College, Cork invites applications for postdoctoral researcher position in the field of semiconductor laser sources for Optical Coherence Tomography (OCT) applications. The successful candidate will join CAPPA group (Centre for Advanced Photonics & Process Analysis) (http://careers.tyndall.ie/content/photonic-device-dynamics-group-0) at the Tyndall National Institute to work under the supervision of Dr. Tomasz Piwonski. This is a funded position for up to 2 years.The aim of this project is to develop new continuous wavelength tuned (swept sources) semiconductor lasers sources at 850 nm for OCT applications. Such lasers will provide an important breakthrough providing a platform that will enable cutting edge research in biomedical imaging and industrial metrology applications. Optical coherence tomography (OCT) is an imaging technique which enables the acquisition of real-time, high-resolution cross sections of scattering media. It is best known for delivering images of biological tissues however its areas of applications is growing and now includes e.g. nondestructive material testing. The core element of this technique is a light source whose properties directly affect quality of acquired images. The aim of this project it to utilize advanced optical techniques to develop and improve performance of semiconductor lasers source used in OCT thus allowing new application areas to be realised on the back of improved device performance. The researcher will be involved in the design, development, fabrication and integration of the technology and will work in a team with other research groups in Tyndall. The project is a collaborative project with industry.Appointment may be made on the IUA Research Assistant Scale € 36,854 - 39,138 p.a.Qualifications & Experience• The post will require a researcher who holds a PhD in a relevant field such as physics, photonics, optoelectronics or a related discipline. • Strong theoretical and experimental skills and hands-on experience with fabrication and characterization of photonic semiconductor devices (lasers, amplifiers etc.) are essential.• Broad experience in optical spectroscopy.• The candidate must demonstrate an academic record of scientific excellence, independent research.• Experience in programming and communication with laboratory instruments (C++, MatLab, LabView or similar)• Good communication, writing, organization and interpersonal skills.• Highly self-motivated and able to demonstrate initiative.• A capability of working within a project team to achieve results.• A commitment to personal development.Additional skills which would be desirable include:• Design of optical systems using commercial software (Fimmwave, Lumerical etc.)• Designing of photolithography masks.• Operation and programming of microcontrollers• Fast prototyping (CAD, SketchUp, 3D printing…)Responsibilities• Design and simulations of semiconductor photonic devices using commercial software• Fabrication of semiconductor swept source lasers. • Electro-optical characterization. • Review of state of the art (publications in journals, conferences and patents)• Contribute to grant proposal writing for EU and other funding streams.• Engage in the dissemination of the results of the research. Ability to write articles in journals and attend conferences• Participate in Education and Public Engagement activitie, as required.• Ensure all activities are compliant with the Tyndall Quality Management system.• Ensure all activities are compliant with the required Health and Safety standards.Informal enquiries concerning this position can be made to: Tomasz Piwonski (email: [email protected])Step 1 - please click here to download the Application formStep 2 - return the completed Application form, together with your CV, motivation letter and references to [email protected] Handwritten forms will not be accepted.Please note that Garda vetting and/or an international police clearance check may form part of the selection process.At this time, Tyndall National Institute does not require the assistance of recruitment agencies.Tyndall National Institute at University College, Cork is an Equal Opportunities Employer.

8211| Biology Centre Academy of Sciences, Institute of Entomology| Exploring changes in interaction network structure along environmental gradients using a meta-analytical approach| A highly motivated Postdoctoral Researcher is sought to explore the shifts that occur in network structure along natural and anthropogenic environmental gradients. The successful candidate will join the LifeWebs project (www.lifewebs.net), which seeks to understand broad-scale network ecology through collation and analyses of existing published and unpublished datasets. They will be responsible for collating additional network datasets through searches of published literature and requests to authors, management of the database and analyses of network patterns. We are particularly interested in changes in network structure in relation to latitude, elevation, anthropogenic habitat degradation, and habitat fragmentation. The work will span a range of terrestrial interaction network types, including insect-parasitoid, animal-parasite, plant-animal pollinator (including vertebrates), ant-plant mutualism, plant-herbivore, plant-seed disperser, insect-fungus, and vertebrate predation datasets. The position purely analytical, and there is not a field component to the work. There will be opportunities to develop the project in an analytical direction of the postdoc’s own choosing.The successful applicant will join the Ant Research Group (http://antscience.com/) at the Institute of Entomology, Biology Centre Academy of Sciences, Ceske Budejovice, Czech Republic, employed on a grant held by Tom Fayle (http://www.tomfayle.com/index.htm). The Ant Research Group is a dynamic, multinational group studying ant ecology, evolution and biogeography, and is embedded within the Department of Ecology and Conservation Biology, a world-class centre for interaction network research with regular publications in Science, Nature and other leading journals. The position allows the successful candidate to apply for standard research grants from the main Czech grant agency (GACR) to eventually expand the project. The deadline for applications is January 10th 2019, with a start date of April 1st 2019, and the appointment lasting until Dec 31st 2021 (33 months). Applicants from all countries are eligible. Salary for this full time position is CZK 40,000 per month (approx. EUR 1500 pre-tax). Note that living costs in Czech Republic are substantially lower than in many other European countries and the salary is competitive for such position (e.g. http://bit.ly/1NCkQKJ).Required• A PhD degree in network ecology or a related field.• Experience of use of databases, or evidence of ability and interest to learn.• Good publication record for career stage.• Experience in the use of ecological statistical analyses, preferably with a focus on network analyses.Desirable• Previous work using a data collation and meta-analytical approach.• A strong publication record in ecological modelling and/or analysis of biological interactions.• Experience of managing small teams or supervising students for research projects.To apply please send a CV, contact details for three references, and cover letter stating qualifications, previous work and motivation to Tom Fayle ([email protected]).

8182| Agri-Food and Biosciences Institute Northern Ireland (AFBI)| Senior Economist - Environmental Economics – 48 Month Fixed Term Contract| REF: IRC234883DEPARTMENT: Agri-Food and Biosciences Institute Northern Ireland (AFBI)LOCATION: AFBI Headquarters, Newforge LaneAn exciting opportunity as a Project Leader within the Environmental Modelling section of AFBI-Economics contributing to the development of a national and international strategic research programme.Further appointments may be made from this competition should NICS positions become vacant which have similar duties and responsibilities.For more detailed information and to apply, please go to www.nicsrecruitment.org.ukAlternatively, an application pack can be requested by contacting:HRConnect, PO Box 1089, The Metro Building, 6-9 Donegall Square South, Belfast, BT1 9EW. Telephone: 0800 1 300 330. Email: [email protected] requests must include your name, address and reference number IRC234883.Completed application forms must be returned to arrive not later than 12:00 noon (UK time) on Friday 21st December 2018.As women are currently known to be under represented in this occupation across Northern Ireland, applications from women would be particularly welcome.The Northern Ireland Civil Service is an Equal Opportunities EmployerALL APPLICATIONS FOR EMPLOYMENT ARE CONSIDERED STRICTLY ON THE BASIS OF MERIT

8209| Cardiff University, School of Biosciences| Postdoctoral Research Associate in Neuroscience| The Martinez-Garay Lab is seeking a highly motivated and innovativePostdoctoral Research Associateto join us at the School of Biosciences, Cardiff University. The post holder will investigate how cell-cell interactions influence the cellular and molecular mechanisms regulating neural progenitor behaviour during development of the cerebral cortex. The project, recently funded by the Biotechnology and Biological Sciences Research Council (BBSRC) involves histology, in utero electroporation, live imaging, murine genetics and single cell RNA sequencing.The successful applicant will have a PhD in Neuroscience, Developmental Biology or related area and will also be expected to actively contribute to the intellectual environment of the lab and to provide guidance to less experienced lab members, including PhD and project students.This is a full-time position, available for 3 years, from 1 April 2019 fixed term until 31 March 2022.For detailed information on the position and to apply please use the following link:http://krb-sjobs.brassring.com/1033/ASP/TG/cim_jobdetail.asp?partnerid=30011&siteid=5460&AReq=8022BRClosing date: Tuesday, 1 January 2019For informal enquiries about the post and the project please contact [email protected]

8215| LMU Munich, Center for NanoScience| Postdoc position in Perovskites and x-ray diffraction| Project: The goal is to study structural and dynamical properties of perovskite crystals. Perovskite nanocrystals show very interesting optical properties distinct from bulk samples; we develop high energy x-ray techniques to quantify size and crystallinity in complex environment such as porous Si. Now we want to extend these studies also to dynamic properties, i.e. phonons. For this purpose, high energy x-ray scattering experiments will be conducted to access thermal diffuse scattering. Complementary inelastic neutron experiments will be performed to study phonon dispersion. These experiments are essential in order to understand the impact of phonons on the charge transport, as well as heat conductance.Requirements: We are looking for majors from physics with excellent knowledge in optics and solid state physics. A strong enthusiasm for x-ray techniques and semiconductor physics and is required in order to achieve the scientific goals. The x-ray experiments involves basic scientific programming skills for modelling, e.g. Python, as well as remote control of hardware, in particular positioning systems and detectors, by commercial software for a Linux platform. Good communication skills, especially fluent English, are needed to organize measurement campaigns. Experiments at synchrotron x-ray facilities need to be well prepared experiments, therefor a high degree of organizational is needed. For PostDoc applicants, we expect a convincing publication record from the PhD.Group: Nickel Research Group, Faculty of Physics and Center for NanoScience, Ludwig-Maximilians University Munich (LMU)Please apply via the online application tool of the Center for NanoScience. Other forms of application will not be accepted.

8210| Austrian Academy of Sciences, Research Center for Molecular Medicine| Open Position for Postdoctoral Fellow in Inflammation Biology| The Bergthaler laboratory at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, Austria is looking for Postdoctoral Fellows to investigate fundamental molecular questions in the areas of infection, inflammation and pathology. Hypothesis- and data-driven approaches are combined to address pertinent pathophysiological questions on the organ and organism level. Recent studies include Schliehe C et al. Nature Immunology 2015, Bhattacharya A et al. Immunity 2015, Khamina K et al. PLoS Pathogens 2017 and Kosack L et al. Cancer Cell 2019 (In Press).We look for innovative scientists who wish to make a difference to our fundamental understanding of inflammation. How are inflammatory processes initiated, regulated and resolved? When does this lead to pathology? How may inflammation be harnessed for immunotherapeutic opportunities?The host laboratory is interested in local vs. systemic inflammation, immunoregulation, organismal immunometabolism, inter-organ communication and tissue pathology. We employ cutting-edge technologies (e.g. mouse genetics, virus reverse genetics, single cell sequencing, metabolomics, metabolite tracing, CRISPR screens, computational biology) in order to unravel the molecular underpinnings of inflammation.Several projects are available which will benefit from established in vivo disease models, preliminary data, strong bioinformatics support, access to world class core facilities (e.g. sequencing, metabolomics, proteomics, drug screens) and an international and highly collaborative environment.Your Profile:+ PhD in a relevant field (e.g. Immunology, Virology, Molecular Biology, Genomics, Epigenetics, TissueBiology, Computational Biology, Technology Development) or MD/DVM degree.+ Successful publication track record with at least one first-author paper in a peer-reviewed journal.+ Critical, creative, interdisciplinary and proactive mindset.+ Team player with strong communication skills.The Lab: The principal investigator Dr. Bergthaler received training in premier laboratories at the University and ETH Zurich, University of Tokyo and at the Institute for Systems Biology in Seattle. His team consists of nine members representing seven nationalities and different scientific backgrounds, who closely collaborate across projects. The Bergthaler lab is supported by competitive funding from the European Research Council (ERC), the Austrian Science Fund (FWF) and the Austrian Academy of Sciences.Lab Twitter account: https://twitter.com/BergthalerlabLab website: http://www.bergthaler1.atThe Institute: CeMM is a biomedical research institute of the Austrian Academy of Sciences and founding member of EU-LIFE (http://eu-life.eu). CeMM provides a collaborative and dynamic environment for its employees from more than 44 nationalities. CeMM aims to promote equality of opportunity for all with the right mix of talent, competences, and potential and thus we welcome applications from candidates with diverse backgrounds. More information about CeMM: http://cemm.at/The Location: Austria´s capital Vienna is located in the heart of Europe and ranks as one of the most attractive cities worldwide. Vienna hosts one of the headquarters of the United Nations, which together with many academic institutions and companies results in a vibrant melting pot of expat communities who may enjoy, for example, numerous cultural and culinary occasions or the nearby outdoors of the Vienna Woods.Your application:Please submit your application at https://cemm.jobbase.io/job/9rllzqiw and include a cover letter, CV, academic transcripts, and contact details of three referees. Deadline for application is 31 January 2019. Applications will be reviewed on a rolling basis. Starting dates are flexible.

8201| University of Toronto, Department of Pharmacology and Toxicology| University of Toronto Post doc in Cancer Signalling| The University of Toronto is consistently rated as one of the top research institutes in the world. As a member of the largest research-based university in Canada, you will be at the forefront of innovation. You will be an integral member of a community that is changing the world.
The Salmena lab is seeking an independent and motivated postdoctoral fellow to start immediately. on a newly funded project. Our ongoing scientific interests include investigations of perturbations in phosphoinositide signalling and consequences for leukemia development. We use mouse models of human and murine leukemia to investigate therapy targets, chemoresistance and leukemic stem cell biology, thus experience in animal handling, transplantations and leukemia biology will be an asset. Current projects include the characterization of novel genes involved in leukemogenic stemness and therapy resistance.  

By joining our team you will be part of a group of young motivated scientists with ambition for academic excellence and scientific discovery. Our goal is to maintain a productive and collaborative learning environment while striving to enjoy scientific life as a team.
The position will commence with a 1 year contract with the option of further extension.

Projects
• Identify genetic networks in the regulation of leukemia stem cell activity
• Understand the mechanisms of developing and overcoming therapy resistance

Required Qualifications 
• PhD in Molecular or Cell Biology, Biochemistry or equivalent
• expertise in basic cell, molecular and biochemical techniques (western blotting, immunoprecipitations, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
• Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques
• Experience and high motivation to work with mice and primary patient cells
• Rapid understanding and independent analysis of complex data
• Experience in writing scientific reports and papers
• Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, GraphPadPrism, R, BLAST)
• Strong communication skills (oral presentations and writing)
• Fluent English, both in written and spoken

Contact & Application 
Please include a CV, cover letter, a complete list of publications and 2 – 3 references to [email protected]

8226| Moredun Research Institute| Research Scientist| Full-time up to 48 months (Temporary) We are seeking an enthusiastic and conscientious individual to join a research team to work on a NERC-funded project exploring the impact of the gut ecosystem (including both parasites and the microbiome) on immunity, survival and fitness of sheep.This project is part of a NERC LARGE grant (‘The ecology within: The impact of gut ecosystem dynamics on host fitness in the wild’) led by the University of Edinburgh and involves co-investigators from the University of Liverpool, University of Sheffield, Aberystwyth University and James Hutton Institute. The post-holder will work closely with the University of Edinburgh to facilitate collection and processing of samples from the St Kilda Soay sheep population over a four year period, and will be responsible for immunological and parasitological analyses of the samples including preparation of parasite DNA for next-generation sequencing.You will be hard working, with an interest in parasitology and immunology, along with experience in immunological (both cellular and antibody based) and parasitological assays. You will have experience in a leading role in the coordination and execution of sample collection and processing, to take responsibility for collation of data for use by the wider research team, and play an active role in disseminating the results of the project to both academic, industry and lay audiences.For additional information, please contact [email protected]: £28,500 - £43,200 placement the on the scale is dependent on experience and qualificationsRef: 01-12-2018Closing Date: 7 January 2019APPLICATION FORMS AND FURTHER PARTICULARS:Full details of this role including the job description and person specification are included in our application pack on our website http://www.moredun.org.uk/careers/available-positions. http://tinyurl.com/y8mb3mfuPlease complete the declaration and equal opportunities forms within the pack and return them with your application. Email: CV, covering letter, completed declaration and equal opportunities forms to [email protected]

8225| University of Southampton, Southampton General Hospital| Research Fellow in Allergy and Inflammation Research: Foundations for routine 3D X-ray histology| This post will support the biomedical aspects of a Wellcome Trust-funded collaboration between Medicine and Engineering at the University of Southampton. With industrial partners, the project will further develop a micro-computed tomography (µCT) system optimised for soft tissue imaging. This will provide novel, high-quality 3D images, enabling scientific & medical discovery through X-ray histology, augmenting traditional histology.We have demonstrated that X-ray imaging by µCT allows non-invasive 3D imaging of tissue microstructure. This yields details comparable to 2D optical microscope sections but for the whole tissue volume this 3D information was previously inaccessible. Improved technology, including new X-ray equipment and standardised and automated workflows developed in this project, will open new areas of research, such as large-scale 3D histological phenotyping (“histomics”). This will translate directly into next-generation clinical image-based diagnostics and patient stratification using artificial intelligence and deep learning.The post holder and an existing Bioengineering Research Fellow will concentrate on biomedical aspects of 3D imaging and 3D image data processing, while another PDRA will design and optimise computational and data management. Specifically, this post will drive and validate biomedical µCT applications leading work on sample preparation protocols for histology and µCT imaging. Part of the study and the post holder’s portfolio will involve planning and executing collaborative systematic comparisons of structural features imaged by µCT and conventional histology. Research exemplars, such as lung and colon will be developed with biomedical research collaborators. The validation of µCT imaging by side-by-side comparison with conventional histology and specialist stains will be an important part of the work. Automated procedures for µCT scanning, image post-processing and quantification will be established. The post holder will be involved in organising and attending events for promoting and disseminating the technology development. This will include teaching and outreach events as well as scientific workshops and conferences. Applicants should have a PhD* or equivalent professional qualifications and experience in a relevant discipline, ideally have a biological background and experience of imaging with a good understanding of image analysis and processing. Enthusiasm and a commitment to help implement the study is essential. You must be able to work independently and proactively and should have a high level of organisational and communication skills.The post will be based at University Hospital Southampton (UHS) within the Biomedical Imaging Unit (BIU; https://www.southampton.ac.uk/biu), which is also part of the NHS histopathology service and will host the new µCT scanner. The BIU is extremely well equipped with a wide range of light and electron microscopes including 3D microscopes (light sheet, serial block-face SEM). This is a collaborative project together with the µ-VIS X-ray Imaging Centre in Engineering (http://www.southampton.ac.uk/muvis). Training and support to develop your knowledge and experience in µCT, microscopy and histology is available from the experienced staff in µ-VIS, the BIU and from other members of the wider project team.Aligning with a broader multidisciplinary team (including respiratory medicine, cell biology, pathology, microscopy, bioengineering, computing/information science and industrial partners), results and publications from this work will provide a key contribution to developing this technology and translating it into diagnostic use, ultimately bringing a novel µCT system to the market.The Faculty of Medicine holds an Athena SWAN Silver Award demonstrating commitment to equal opportunities and gender balance in the workplace. The Faculty recognises that applicants may seek flexible working patterns which will be considered as part of the recruitment process. For further information including key benefits designed to help maintain and support employees' well-being and work-life balance, please see our working with us website pages.The post will be available from January 2019 for a period of 27 Months. Informal enquiries: Dr Peter Lackie; 023 8120 4146, email: [email protected] or Dr Philipp Schneider; 023 8059 4640, email: [email protected] note: The University Recruitment department will be closed from close of business on Thursday 20th December 2018 to Wednesday 2nd January 2019, so we will not be able to assist you with any application queries during this time.Application Procedure:You should submit your completed online application form at https://jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Georgie Warren (Recruitment Team) on +44 (0)23 8059 7749. Please quote reference 1082818FC on all correspondence.*Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.

8193| University Hospital Heidelberg| Postdoc (m/f) Stem Cells and Therapy Resistance in Acute Myeloid Leukemia| The Heidelberg University Hospital is one of the most important medical centers in Germany and stands for the development of innovative diagnostics and therapies as well as their rapid implementation for the patient. With approximately 10,000 employees in more than 50 clinical specialist departments with approximately 1,900 beds, around 66,000 patients are treated on an intpatient basis or 1,000,000 times on an outpatient basis.The work in our research group focuses on stem cells and therapy resistance. We aim to understand how epigenetic dysregulation participates in the pathogenesis and chemo-resistance of AML. To follow this question, a broad number of in-vitro- and in-vivo-models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse. The current position is funded by a new project grant from the DFG (Deutsche Forschungsgemeinschaft).Related Publications:Göllner, S. et al.: Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia (AML). Nature Medicine 2017 Jan; 23(1): 69 – 78.Zhou, F. et al.: AML1-ETO requires enhanced C/D box snoRNA formation to induce self-renewal and leukemia. Nature Cell Biology, April 2017.The position is limited to 2 years with the option of further extension.Tasks • Identify genetic networks in the regulation of human leukemia stem cell activity• Understand the mechanisms of developing and overcoming therapy resistanceRequired Qualifications • PhD in Biology, Biochemistry or equivalent• Broad expertise in basic cell- molecular and biochemical techniques (western blotting, immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)• Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques• Experience and high motivation to work with mice and primary patient cells• Driving independently the experimental and project designs• Rapid understanding and independent analysis of complex data• Experience in writing scientific reports and papers• Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, Lightroom, GraphPadPrism, R, BLAST)• Strong communication skills (oral presentations and writing)• Fluent English and German, both in written and spokenWe offer• Groundbreaking innovative projects within the field of leukemia research• A highly dedicated, diverse and international team with access to on-site mouse facilities, sequence facilities and unique leukemia samples• Access to state-of-the-art equipment• An exciting and highly translational research field• Presentation and publication of the data at international scientific meetings and in journals• Collaboration with many experimentally or theoretically oriented labs and groups in the university hospital, in the Heidelberg area (e.g. DKFZ, EMBL, NCT) and with international research partners of other organizations abroadContact & Application Applications should be submitted online as one single PDF-file (max 5 MB). Please do not send original documents by mail services, since they will not be returned.Please include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2 – 3 references. For further information, you may contact: Annette Becker, M. A., Science coordinator, phone +49(0) 6221-56-8552.University Hospital Heidelberg Internal Medicine V Department of Hematology, Oncology, RheumatologyAnnette BeckerIm Neuenheimer Feld 41069120 Heidelberg, Germanyphone +49(0) [email protected] The University Hospital Heidelberg offers• individual, target-oriented advanced training • ticket for public transport • nursery and kindergarten as well as holiday organization for schoolchildren • health promotion• university sports / librarywww.klinikum.uni-heidelberg.de/Jobs-KarriereWe stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.

8208| The University of Luxembourg, the Luxembourg Centre for Systems Biomedicine| Postdoctoral researcher in Microbial Systems Ecology (m/f)| AREA: Modelling the Factors Governing Microbial CommunitiesWe are seeking a highly motivated and creative scientist with an outstanding record in scientific research who can independently design and execute experiments. More specifically, we are seeking an individual with strong interests in microbial population ecology. The postdoctoral candidate to be hired will have a strong background in mathematics, physics, computer science, microbial ecology and/or bioinformatics.Knowledge of the factors which govern microbial community structure and function is essential to predict community dynamics and to control microbial ecosystems. In biological wastewater treatment plants, predictive understanding of the populations dynamics within the community is required to design sewage plants of the future. The post-doc researcher working on the GoMiCo project will integrate, analyse, and model time-resolved meta-omics data along with corresponding environmental and operational data to unravel the main biotic and abiotic factors governing microbial population dynamics. The aim of the GoMiCo project is to ascertain which factors affect community composition and will lead to the development of strategies for the control of specific populations. The developed approaches will be generalizable to other microbial communities including those constituting the human microbiome.The Luxembourg National Research Fund-supported position will be hosted by the Eco-Systems Biology Group at LCSB (head: Prof. Paul Wilmes) in cooperation with Prof. Karoline Faust (KU Leuven), Dr Stefanie Widder (Konrad Lorenz Institute for Evolution and Cognition Research) and Prof. Dr Joachim Hansen (University of Luxembourg). For further information, please contact:Prof. Dr Paul WilmesE-mail: [email protected]: +352 46 66 44 6188YOUR ROLE:• Integration and analysis of multi-omic (metagenomic, metatranscriptomic and (meta-)metabolomics) data.• Application of different time-series analysis methods to the data.• Development of a model for predicting population dynamics based on biotic and abiotic factors.YOUR PROFILE:• A PhD in microbial ecology, bioinformatics, mathematics, physics, or computer science.• Strong publications record.• Previous experience in microbiology and in analysing and/or modeling time-series community data are strongly encouraged.• Previous wet-lab experience is considered an asset.Excellent working knowledge of English.WE OFFER:• Fully funded position.• An exciting international environment.• The University offers competitive salaries and is an equal opportunity employer. FURTHER INFORMATION:Applications (in English) should contain the following documents:• A detailed curriculum vitae• Cover letter mentioning the reference number• List of publications• Description of past research experience and future interests• Name and addresses of three refereesThank you for applying ONLINE

8200| University College Dublin| AbbVie Newman Fellowship in Inflammatory Bowel Disease| As part of its programme to provide postdoctoral research opportunities for scholars of proven academic excellence, University College Dublin is pleased to announce the AbbVie Newman Fellowship in Inflammatory Bowel Disease.The Fellowship is established at the UCD School of Medicine at UCD and the Centre for Colorectal Disease, St Vincent’s University Hospital, with support from AbbVie. The Centre for Colorectal Disease is actively engaged in clinical and translational research with a focus on understanding which cellular and molecular factors drive disease progression and condition response to treatment in inflammatory bowel disease.The AbbVie Newman Fellow will be expected to have completed a PhD in Immunology or a closely related field of Biomedical Science. The fellow must be first author on at least one high-impact peer-reviewed publication and demonstrate commitment to conducting high quality biomedical/translational research studies in Inflammatory Bowel Disease patients. Experience in primary cell isolation from blood and tissue and high dimensional flow cytometry is required.The Fellow will register with the UCD Translational Medicine programme as part of a two-year Masters research programme.A completed Newman Fellowship Application Form, a copy of your CV and two copies of the Newman Fellowship Referee Form (both found here: https://www.ucdfoundation.ie/newman-fellowship/current-vacancies/) should be returned to:UCD Graduate StudiesTierney BuildingBelfield, Dublin 4T: 01 716 4047E: [email protected]

8202| Agri-Food and Biosciences Institute Northern Ireland (AFBI)| Research Economist| An opportunity to join a dynamic team of research economists exploring regional, national and international agri-food and rural affairsFurther appointments may be made from this competition should AFBI positions become vacant which have similar duties and responsibilities.For more detailed information and to apply, please go to www.nicsrecruitment.org.ukAlternatively, an application pack can be requested by contacting:HRConnect, PO Box 1089, The Metro Building, 6-9 Donegall Square South, Belfast, BT1 9EW. Telephone: 0800 1 300 330. Email: [email protected] requests must include your name, address and reference number IRC234391Completed application forms must be returned to arrive not later than 12:00 noon (UK time) on Wednesday 2nd January 2019Applications are particularly welcomed from Roman Catholics and Females as these groups are currently under-represented within AFBI.AFBI is an Equal Opportunities EmployerALL APPLICATIONS FOR EMPLOYMENT ARE CONSIDERED STRICTLY ON THE BASIS OF MERIT