8378| University of Otago, Department of Anatomy| Postdoctoral Fellow - Arginine Metabolism and Tauopathies| The DepartmentThe Department of Anatomy is one of the largest and longest-established departments at the University of Otago. Our staff teach and research a diverse range of exciting topics in the field of biomedical sciences, including neuroscience.The RoleAs a Postdoctoral Fellow, you will be responsible for carrying out a project to systematically investigate how the brain arginine metabolism (the polyamine system in particular) changes in tauopathies such as Alzheimer's disease and frontotemporal dementia.Duties will include:• Enzyme assays, western blot, real-time quantitative PCR and high performance liquid chromatography and liquid chromatography/mass spectrometric assays.• Tissue collection and preparation.• Data collection and data entry.• Statistical analysis of data.• Writing manuscripts reporting on research results for publication in peer-reviewed journals.• Presenting findings at scientific meetings.• Assisting in writing grant applications and pursuing funding opportunities.• Assisting with writing progress reports to the funding organisation.Your Skills and Experience• PhD in an appropriate neuroscience or biological science.• Experience in enzyme assays, western blot, real-time quantitative PCR and high performance liquid chromatography and liquid chromatography/mass spectrometric assays.• Evidence of ability to publish.• A thorough approach to laboratory practice, accurate record-keeping, attention to detail and compliance with all regulatory requirements.• Ability to work cooperatively with a wide variety of people within a research environment.• Ability to work without direct supervision, set priorities and allocate own timetable.• Self-motivated, and committed to a research career in the biological sciences.Further detailsThis is a full-time, fixed-term position for two years and is available from 1 July 2019.Applications quoting reference number 1900473 will close on Sunday, 24 March 2019.APPLICATION INFORMATIONTo view all current vacancies and to apply online go to: https://otago.taleo.net/careersection/2/jobdetail.ftl?job=1900473Equal opportunity in employment is University policy.E tautoko ana Te Whare Wananga o Otago i te kaupapa whakaorite whiwhinga mahi.

8413| D. E. Shaw Research| Postdoctoral Fellowships in Computational Chemistry and Biology at D. E. Shaw Research| D. E. Shaw Research is seeking postdoctoral fellows of exceptional ability to join our New York–based team. This is a unique opportunity to develop and work with transformative technology in a dynamic, interdisciplinary environment. Candidates should have expertise in computational biophysics or chemistry, structural biology, drug discovery, or in a relevant area of computer science. Relevant areas of experience might include direct application of molecular dynamics or other computational methods to drug discovery, investigation of allosteric interactions or other functionally important conformational changes in biological molecules, structure prediction or design for proteins or RNA, study of protein–protein or protein–nucleic acid interactions, or study of fundamental biophysical problems, such as protein and RNA folding. Specific knowledge of any of these areas is less critical, however, than outstanding intellectual ability, unusually strong research skills, and a history of innovation and accomplishment. We are committed to fostering a stimulating, rewarding, and flexible work environment, and we offer above-market compensation to candidates of truly exceptional ability.To submit an application, please use the link provided below: http://www.deshawresearch.com/recruit/jobs/Ads/FindAPostDoc/ChemPF-AD. E. Shaw Research is an independent research group that is pursuing an ambitious, long-term strategy aimed at fundamentally transforming the process of drug discovery. We have developed a special-purpose supercomputer, ANTON®, capable of executing molecular dynamics (MD) simulations orders of magnitude faster than was previously possible. Our current projects include investigations of proteins and other biomedically relevant macromolecules as well as the development of computational chemistry methods to enable more accurate and effective MD simulations.D. E. Shaw Research is an equal opportunity employer, dedicated to the goal of building a diverse workforce. We welcome inquiries from all exceptionally well-qualified applicants, regardless of race, color, nationality, national or ethnic origin, religion or religious belief, caste, gender, gender identity, pregnancy, caregiver status, age, military service eligibility, veteran status, sexual orientation, marital or civil partner status, disability, or status in any other category protected in this regard by law in any jurisdiction in which the Firm operates.

8401| Western College of Veterinary Medicine, Large Animal Clinical Sciences| Postdoctoral position Swine Welfare| Research areas: This work forms part of an NSERC supported, five-year research collaboration between the University of Saskatchewan, several academic collaborators, and 14 industry partners, to advance understanding on several areas of importance to improving the welfare of farmed swine. A summary of this research program can be found here. The chosen candidate will be required to lead scientific investigation into the following areas: 1) Understand the value of animal-based indicators of welfare as measured on carcasses at the abattoir, to provide a continuous herd welfare monitoring tool. This work involves investigation into the prevalence of animal-based indicators of welfare on carcasses in Canadian abattoirs, and determining the relationship between animal-based indictors of welfare on farm, to those observed on carcasses. 2) Understanding the contribution of early life management practices towards resilience characteristics, sociability traits and welfare outcomes in the growing pig. Working alongside team members exploring the contribution of early life management to influence pig development and resilience characteristics (including behavioural, response to stressors, and gut health), the post-doctoral researcher will lead scientific investigation into the relationship between the adaptive response of the pig and the development of welfare problems later in the growing life, with a focus on: i) the relationship between adaptive response, gut health and development of problem behaviours, and ii) understanding the contribution of early life influences towards the development of sociability traits and long term group functioning, including the role of social play to influence such traits. This work will also involve collaborative work with team-members validating specific biomarkers to inform on welfare states. Collectively, the research conducted during this post-doctoral position will contribute towards understanding the causal factors behind the development of specific welfare problems, the inputs required for commercially viable production environments to support higher welfare, and methods to support regular measurement of welfare from large numbers of animals. The candidate will benefit from working within an active research environment, and connecting research findings to application with stakeholders.Duties: Manage assigned areas of the research project, including: planning, data collection, statistical analysis; communication of research findings through scientific meetings and publications; industry liaison and knowledge transfer of results to stakeholders; grant writing as required. The successful candidate will be required to work closely with research collaborators, both academic and industry, and to support progress of the overall research program. Work will require periods of travel for data collection to facilities across Canada. Eligibility: A PhD in field of applied ethology, animal welfare science, animal science, zoology, veterinary medicine, comparative psychology or related discipline; a valid driver’s license. Candidate skills: Excellent written and oral communication skills, a strong work ethic, the ability to work independently and within a team, initiative and problem-solving ability, and good organizational skills are essential to this role. Candidates with a strong multidisciplinary skill set are desirable, with a good knowledge of biology, experience in welfare assessment, animal behaviour, statistical analysis and laboratory skills, publication record and experience of grant writing preferable. Experience and knowledge of pigs and pig production is considered an asset. For further information about this position & to apply please contact Dr. Yolande Seddon: E-mail: [email protected]; Telephone: +1-306-966-7151Large Animal Clinical Sciences,Western College of Veterinary MedicineUniversity of Saskatchewan, Saskatoon, Canada.Learn more about the University of Saskatchewan at: https://www.usask.ca/ and the Western College of Veterinary Medicine at: http://www.usask.ca/wcvm/Applications: Please submit a current CV, a one-page cover letter outlining your motivation and qualification for the position and contact details of two references to Dr. Yolande Seddon. E-mail submissions, please include in the subject heading: Post-doc Swine Welfare. This position will remain open until filled. Review of applicants will begin upon receipt, and applicants will be contacted for an interview.

8391| University of Edinburgh, The Roslin Institute| Research Fellow| We are looking for an enthusiastic researcher with experience in quantitative genetics / statistical modelling to join at the Genetics and Genomics Division of The Roslin Institute and the Royal (Dick) School of Veterinary Studies, University of Edinburgh. The post is part of the H2020 SMARTER research project, which aims to develop and deploy innovative strategies to improve resilience and efficiency (R&E) related traits in sheep and goats. Your main role will be to develop new statistical methods to analyse genetic resilience and efficiency of animals under diverse micro-and macro- environmental challenges, test these with simulated and diverse real datasets available within SMARTER, and to implement these into innovate genomic breeding strategies suited to small ruminant populations.Essential requirements:• PhD, or near completion of a PhD, in a discipline with a substantial quantitative component (e.g. quantitative genetics, mathematics, statistics, theoretical biology or physics)• Strong background in quantitative genetics and genomics or statistical modelling of large, multi-dimensional datasets • Excellent programming skills and experience in writing computational code for simulating and analysing population data. • A strong track record of research outputs, publications in peer reviewed scientific journals and presentations at scientific conferences.• Strong written and verbal communication skills.Informal enquiries are encouraged and may be addressed to Dr Ricardo Pong-Wong ([email protected] or phone +44 131 6519220), or Prof Andrea Wilson ([email protected], tel. +44 131 6519224) in confidence to discuss the post.Ref: 047086. Closing Date: 28th March 2019.For more information and to submit an application, please use the ‘apply’ button below.Link: https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=047086

8405| Tallinn University of Technology, Centre for Biorobotics| Postdoctoral Position in Robotics for Extreme Environments| The Centre for Biorobotics is a team of 15 young, skilled and well-motivated researchers and engineers in Tallinn University of Technology (TalTech), Estonia. We love novel, unusual and risky ideas and new applications for our technology. We are looking for new team members to work on robot sensing and locomotion, taking robots to places and solving tasks they have not been able to do before. In particular, we are on the lookout for good people for the following two postdoc positions:1. Robot locomotion in multiphase environments. This involves proposing novel ideas and building and testing robot prototypes for locomotion in fluids with different properties. The robots will move both on solid ground and in the environments between them; in mud of different consistencies, clay, oil, wet snow, loose gravel, etc. 2. Robot sensing in sensory-deprived and GPS-denied environments. This involves developing unconventional robotic sensors for environments where the common sensors cannot work (e.g. caves filled with slurry, ice caves, highly turbid water, etc.). The purpose of these new sensors will be to build world models and navigate through highly uncertain underground and underwater environments. Apart from a strong theoretical background and practical skills in robotics and physics, this assignment requires independent thinking and willingness to stretch your limits. Since we work tightly coupled in several international projects, we need people who are good at working with others. Also be prepared for field testing in conceivably uncomfortable conditions (rain, snow, mud etc.). If you feel that you are interested, please consider our offer of 20 000 – 30 000 EUR annual salary, friendly, supportive, internationally well-connected research team and state-of-the-art experimental facilities. TalTech has a young, lean and efficient university management where good ideas are welcome and can be put in practice without bureaucratic hassle. You would be located in Tallinn, Estonia, which is one of the fastest-growing IT hubs in Europe.We are also creating opportunities for young researchers to stay here longer and build up your academic career in Taltech.http://www.biorobotics.ttu.eehttps://www.facebook.com/Centre-for-Biorobotics-Tallinn-University-of-Technology-179976838681982/

8398| King's College London| Research Associate/Fellow in Imaging Cancer Drug Resistance| The salary will be paid at Grade 6 (Research Associate) £37,412-44,015 or Grade 7 (Research Fellow) £45,259 per annum, inclusive of £3,223 per annum London Allowance.This post will be offered on a fixed-term contract until 31/3/2022.This is a full-time post - 100% full time equivalent.We are seeking a talented, enthusiastic and experienced molecular imaging scientist to work in the Molecular Imaging Lab in the Department of Imaging Chemistry and Biology (www.witneylab.com). This post is part of the City of London Major Centre, a network of researchers and clinicians funded by Cancer Research UK to advance cancer diagnosis and treatment for patient benefit. The post holder will work across multiple projects in the Group to support the biological evaluation of novel fluorine-18 labelled positron emission tomography (PET) radiotracers to image cancer drug resistance. We are looking for someone with widespread knowledge of molecular biology techniques, small animal PET imaging and cancer biology. Those with expertise in biotherapeutics are particularly encouraged to apply.This is an exciting opportunity to join a vibrant multidisciplinary research Group within one of the premier biomedical imaging centres in Europe. The Department of Imaging Chemistry and Biology is part of the School of Biomedical Engineering and Imaging Sciences which has a vast array of small animal and clinical imaging modalities, including a state-of-the-art nuclear medicine facility, supported by the cutting-edge equipment and core facilities at King’s.The selection process will include a panel interview and a presentation.For an informal discussion to find out more about the role please contact: Dr Tim Witney, [email protected] To apply, please go to: https://bit.ly/2TnRwq4 and register with the King’s College London application portal and complete your application online.Closing date: Midnight on 31st March 2019.

8406| Teagasc, Gender and Organisational Development| Post-Doctoral Research Fellow - Gender and Organisational Development| The Teagasc post-doctoral programme provides training and development opportunities for early career scientists that enhances their experience of learning and equips them with the necessary skills for the next stage of their chosen career in research. The successful candidate will be a member of the project team and consortium on the Gender-SMART project. The Gender-Smart project focuses on achieving gender equality in research performing and research funding organisations operating in the agriculture and life sciences research field. Teagasc will work with EU partners across the work packages of Gender-SMART to address this challenge.The Gender-SMART work programme focuses on designing, developing and implementing Gender Equality Plans (GEP) within the partner organisations. GEP strategies and actions will be co-designed with internal stakeholders to create awareness, ownership and integration within the institutional framework. Teagasc has particular responsibility for building a gender equality culture within the partner organisations whereby individuals are equally free to develop and enhance their personal skills and capacities irrespective of their sex or gender identity. This includes mobilising stakeholders at all levels in the organisations to engage and contribute to embedding the gender equality culture in their organisation.This is a research focused training role, the primary purpose of which is to provide early career scientists with the opportunity to develop their research skills and competencies.The PD Fellow will, while working in conjunction with senior research staff, gain insight and experience into a variety of areas including the processes of project and budgetary management, the development of active collaboration with relevant national and international research communities, the development of communication and presentation skills, leadership and management skills, and overall career development.The PD Fellow will conduct a specified programme of research, supported by a modular training programme, which will include modules of relevance for the development of specific knowledge and research skills, professionalism and communication skills, leadership and management skills, and overall career development.Modules will be conducted under the supervision and direction of Jane Kavanagh or other designated manager in conjunction with the Head of Department.The final 6 months of this programme will be at the Post-Doctoral Research Fellow Level 2 (PD2). This advanced research focused training role provides experienced post-doctoral researchers with the opportunity to build on their prior experience and is supported by a modular training programme, which will include modules of relevance to enhance their development of specific knowledge and research skills, professionalism and communication skills, leadership and management skills, and overall career development. Duties & Responsibilities specific to this project:• Undertake a review of the relevant literature to contribute to the design, development and implementation of gender equality plans in Teagasc and across the Gender-SMART consortium.• Undertake collaborative and participatory approaches to develop practice oriented knowledge to support gender equality plan design and implementation.• Develop an approach and framework to collate and manage gender related data in Teagasc.• Organise meetings and workshops nationally and internationally.• Prepare draft financial and scientific reports periodically for submission to the European Commission.• Assist in the implementation of a gender equality plan in Teagasc and embedding a gender equality culture across the Gender-SMART consortium.Additional Duties & Responsibilities:• Interpret research findings and prepare scientific and popular press publications.• Disseminate research findings to a variety of audiences as appropriate.• Assist Teagasc in meeting the commitments of the Quality Customer Service Charter and action plan.• Comply with all relevant Teagasc policies and procedures.• Actively participate in the Teagasc Post Doctoral Fellowship programme and review processes, and to undertake all Post Doctoral fellowship training and associated duties as agreed in the Training & Development Plan.• Fully co-operate with the provisions made for ensuring the health, safety and welfare of themselves, fellow staff and non-Teagasc staff and co-operate with management in enabling Teagasc to comply with legal obligations. This includes full compliance with the responsibilities outlined in the Safety Statement.• Take up additional duties as may arise or as assigned by management.Person SpecificationThis section outlines the qualifications, skills, knowledge and/or experience that the successful candidate would be required to demonstrate for successful discharge of the responsibilities of the post. Applications will be assessed on how well candidates satisfy these criteria.Essential• PhD in gender studies or related discipline.• Relevant research experience not to exceed 3 years’ post-PhD.• Demonstrated research and technical expertise in gender and/or organisational development and behaviour or change management.• Evidence of research activity (publications, conference presentations, awards) and future scholarly output (working papers, research proposals etc.).• Excellent project management, analytical, report writing and data analysis skills.• An ability to collaborate with team members and PhD students to help build research knowledge and skill and to guide professional development.• Excellent communication skills (oral, written, presentation) with an ability to enable effective knowledge and technology transfer.• Ability to generate new ideas, unique concepts, models and solutions.• Full EU Driving Licence.Desirable• Experience in applied gender research and organisational change.• Experience in setting own research agenda.• Evidence of teamwork and collaboration with relevant partners.Further Information for Candidates Candidates can access a Fellowship Programme Application form for this post on the Teagasc website at https://www.teagasc.ie/about/opportunities/post-doctoral-opportunities/. Teagasc do not accept Curriculum Vitae’s as an application for a position. In order to apply for a post the relevant application form must be completed in order to be considered.Completed application forms should be TYPED, saved in PDF format and submitted by email to [email protected] no later than 12 noon on Wednesday 27th March 2019. Applications received after this time will not be considered.Teagasc is an equal opportunities employer. As part of Teagasc Gender and Diversity strategies, Teagasc welcomes a balanced pool of applicants. Canvassing will disqualify.The details contained above are subject to change without notice.

8402| University College Dublin, UCD School of Business, HRM and Employment Relations Group| UCD Postdoctoral Research Fellow Level 1 in Labour Politics and the EU’s New Economic Governance Regime, UCD School of Business, HRM and Employment Relations Group (Tenporary 3 Year Post)| Applications are invited for a temporary 3-year, full-time postdoctoral appointment in European integration and employment relations, starting on 1st September 2019 or by agreement.You will be a member of our ERC funded research team on the EU’s new economic governance regime (NEG) and the contradictory trajectories for trade unions and social movements it is opening. The ERC project focuses on the way in which European trade unions and new social movements in the public transport, water, and health care sectors respond to the EU’s new economic governance regime. Until very recently, European labour politics has been shaped mainly by EU ‘horizontal’ market integration through the free movement of goods, capital, services, and people. Since the Euro crisis, however, the latter has been complemented by ‘vertical’ hierarchical integration effected through the direct surveillance of member states’ macroeconomic policies, including industrial relations and public services provision. The resulting new EU economic governance regime (NEG) opens contradictory possibilities for labour politics in Europe. Are unions and social movements politicising NEG along national or (transnational) class divides?Salary range: €37,223 - €43,029 per annumAppointment on the above range will be dependent upon qualifications and experience.Closing date: 17:00hrs (local Irish time) on 2nd May 2019Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/. UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.

8396| Robert Gordon University, School of Pharmacy & Life Sciences| Research Fellow| The School of Pharmacy and Life Sciences is a vibrant academic community and provides education in a number of subjects including pharmacy, forensic science, biomedical science and nutrition. The School is housed in a state of the art building and has facilities designed to simulate both clinical and community settings providing a stimulating learning environment.Our vision is to provide dynamic and transformational learning, teaching and research that makes a leading contribution to improving the health and well-being of local, national and global communities.An exciting opportunity has arisen for a Research Fellow to join our team. You will have a PhD in a relevant health care subject, a proven track record in leading and contributing to research and a sound publication profile.This 2-year post at RGU is part of a BBSRC-funded project on “Delineating the roles of GPR55 in cellular metabolism and energy homeostasis”, run jointly between Robert Gordon University and the University of Dundee.This post is for a Postdoctoral Research Fellow to explore the role of GPR55 in cardiac energy metabolism and function. The project will involve small animal surgery, performing in vivo pressure-volume loop analysis and ex vivo Langendorff perfused heart studies in mice with a genetic deletion for GPR55, alongside a range of biochemical tissue analyses. The experimental work will be carried out in the Cardiometabolic Health Research laboratories, led by Professor Cherry Wainwright at the School of Pharmacy and Life Sciences at Robert Gordon University , as part of the joint project with Professor Hari Hundal in the School of Pharmacy and Life Sciences at the University of Dundee.The successful applicant will join a multidisciplinary team investigating a variety of projects utilising cell- and tissue- based studies and animal models of cardiovascular disease.Please direct any enquiries in the first instance to Professor Cherry Wainwright ([email protected]) who will be pleased to provide more information about the post.This post is subject to a Disclosure Scotland check. For more information visit: https://www.mygov.scot/standard-disclosureSalary on first appointment is normally to the bottom of the scale, although in exceptional circumstances an appointment further up the scale may be considered.Closing Date: 07 April 2019

8400| King's College London| Research Associate/Research Fellow in Cancer Molecular Imaging| Ref. 010906The salary will be paid at Grade 6 (Postdoctoral Research Associate) £37,412- £44,015 or Grade 7 (Research Fellow) £45,259 per annum, inclusive of £3,223 per annum London Allowance.This post will be offered on a fixed-term contract until 31/3/2022.This is a full-time post - 100% full time equivalent.Please note that the purpose of the advert is to direct candidates to the job pack. As such, please ensure that your advert text is high impact and succinct. In depth description of the role should be contained in the job pack. The City of London Major Centre is a network of researchers and clinicians funded by Cancer Research UK to advance cancer diagnosis and treatment for patient benefit. We are seeking an experienced Molecular Imaging Scientist to support the Centre’s research activities in radiopharmaceuticals for imaging and treating cancer. The post holder will play a central role in developing new radiopharmaceuticals targeting various cancer-related phenotypes and translating them to clinical use within the Centre. We are looking for someone with a range of biomolecule and cell labelling, radiochemistry, and preclinical biological evaluation skills, with a particular emphasis on cancer biology. This role will encompass varied responsibilities, including work on a wide range of collaborative projects. The role will be a basis for first- and senior author publications on the development of innovative methodologies in this field as well as co-authoring user-led publications. Overall, we are looking for someone to maximise dissemination of our innovations to benefit the research community within the Centre, within KCL, externally, and ultimately patients.The selection process will include a panel interview and a presentation.For an informal discussion to find out more about the role please contact: Phil Blower, [email protected] To apply, please go to: https://bit.ly/2TixuNP and register with the King’s College London application portal and complete your application online.Closing date: Midnight on 31st March 2019.

8407| University College London| Research Fellow in Biomedical Molecular Dynamics for Drug Discovery| Applications are invited for a Research Fellow to work with Professor Peter Coveney in the Department of Chemistry at University College London. The successful candidate will join a very active inter-disciplinary group in the Centre for Computational Science, working on projects in fields ranging from condensed matter physics and chemistry to life sciences and medicine. This post will involve the development of molecular models to support computer-based drug discovery and to investigate the biophysical and biochemical origins of drug resistance in pathologies such as HIV, cancer, and antimicrobial resistance, using established molecular dynamics codes such as NAMD and OpenMM. A key element of the approach is the development and use of automated workflows to assist in the rapid, accurate, precise and reproducible determination of binding affinities running on a range of ultra-high-end supercomputers, including Summit, number one in the Top500 list of supercomputers worldwide. The postholder will work closely with a large number of international projects across Europe and USA, and with collaborating industrial (pharma/biotech) and public sector partners who have an interest in exploiting our approaches in industry and healthcare. The post is funded by the European Commission and is available from 1 April 2019, for a period of 24 months initially. A PhD degree (or near to being awarded a PhD) in biomolecular dynamics as used to perform free energy and related calculations of ligand-protein binding is essential, as is extensive experience with high performance computing. The postholder must also have experience of using common molecular dynamics packages including at least two of NAMD, AMBER, GROMACS and OpenMM. An excellent and consistent publication track record is also essential. Please note, appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £30,922 to £32,607 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.For further details about the vacancy and how to apply online please go to https://www.ucl.ac.uk/human-resources/working-ucl/jobs-ucl and search on Reference Number 1796578 Informal enquiries should be addressed to Prof Peter Coveney ( [email protected] ). Any queries on the application process can be directed to Judith James – [email protected] .Closing Date: 10 April 2019Latest time for the submission of applications: 23:59.Interview Date: TBCWe particularly welcome female applicants and those from an ethnic minority, as they are under-represented within UCL at this level. Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.To apply click here: https://atsv7.wcn.co.uk/search_engine/jobs.cgi?owner=5041178&ownertype=fair&jcode=1796578

8409| University of Tübingen (German Excellence University), Department of Immunology| Postdoc Innate Immunity| Topic | Innate immunity plays a critical part in the host defense against infection but also in cardiovascular, neurodegenerative, metabolic and malignant diseases. Primary regulators of innate immunity are the so-called pattern recognition receptor (PRRs) which sense internal or external danger and trigger molecular and cellular responses that lead to immunological effector responses. Our lab has a strong track record in PRR signaling pathways and has been contributing insightful results in the areas of microbial recognition, initiation of inflammation and oncogenesis. At current, our activities are focused on the recognition of fungal chitin by TLRs, the regulation of the NLRP3 inflammasome by Bruton’s Tyrosine Kinase (BTK), MyD88-dependent oncogenic signaling pathways and the role or neutrophil extracellular trap (NET)-associated RNA (naRNA) in psoriasis and neutrophil activation. Our vision is to elucidate the molecular workings and immunological consequences of these disease-relevant processes to a level that will allow for safely harnessing their considerable translational potential. We do so together with many academic, clinical and industrial partners in Tübingen, in Germany and abroad. The postdoc position is aimed to considerably strengthen these research areas, especially our focus on BTK-NLRP3 inflammasome function. Suggested reading | Liu et al., J Allergy Clin Immunol 2017: Human NACHT, LRR, and PYD domain-containing protein (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase | Fuchs et al., EMBO Rep 2018: The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size | Weber et al., Cancer Immunol Immother 2018: Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities | Herster et al., Biorxiv 2019: Neutrophil-extracellular trap-associated RNA (naRNA) and LL37 enable self-amplifying inflammation in psoriasis.Methods/skills | Immunology techniques (PBMC preparation, cell culture of cell lines and primary human/ mouse immune cells, ELISA, flow cytometry), molecular biology (mutagenesis, PCR, sub-cloning), protein biochemistry (SDS-PAGE, immunoblot, immunoprecipitation, chromatography), fluorescence microscopy, in vivo experiments, data analysis (e.g. Prism), scientific writing and presentation. Experience in these areas will be highly desirable.The team | In order to advance our vision and strengthen our efforts we hope to recruit additional excellent and enthusiastic researchers, including one postdoc. You would become part of a research group with a solid track record, and located in an excellent scientific environment, the Department of Immunology, located on the campus of the University of Tübingen, one of Germany’s Excellence Universities. In our well-funded and set-up laboratory you would find a dynamic, friendly, well-connected and internationally minded (English- and German-speaking) environment, and a firm commitment to good supervision and professional development.Further information | Visit our website www.immunology-tuebingen.de. Position to start 06/2019, so apply NOW German TV-L E13 100% Point on salary scale dependent on job-relevant experience. The postdoc position is fully funded for 3 years. Thereafter possibly extendable or upgradable to a junior group leader position (E14 payscale). Your profile | PhD and ideally additional research experience in molecular/cellular biology, microbiology/virology, protein biochemistry and/or immunology and several of the abovementioned techniques; high motivation to work independently and as part of a team; reliability, enthusiasm, critical eye, good documentation skills, very good command of the English language (written and spoken); willingness and ability to supervise/train students, write scientifically and to apply for a faculty-internal grant upon arrival.Your application | Please apply electronically to [email protected] with all of the following: Motivation letter (max. 1 A4), CV, transcripts and certificates (PhD, MSc and BSc), support letter from >1 previous supervisor, English language certificate, other certificates (e.g. FELASA). Both German and international applications encouraged. International applicants will be supported to attend German courses but German skills are not required to apply successfully. Applications will be reviewed on an ongoing basis and interviews scheduled accordingly.

8394| Victoria University of Wellington, Ferrier Research Institute| Postdoctoral Research Fellow in Enzyme Structure and Function| We are seeking applications for a Postdoctoral Fellow to join the Ferrier Research Institute at Victoria University of Wellington as part of project funded by the Marsden Fund, which is New Zealand's premier source of funding for fundamental research. This project will use a combined chemical genetics and structural biology approach to determine the molecular details of enzymes involved in natural product biosynthesis. This project is part of a larger program to deliver new Synthetic Biology approaches to aid the discovery and delivery of bioactive compounds.The position will be for a term of 2.5 years (full-time) starting in early to mid-2019. The fellow will have the opportunity to contribute in project planning, as well as co-supervision for PhD students.The ideal candidate will have a PhD in structural biology, enzymology or biological chemistry or another relevant discipline and be able to work productively in a multidisciplinary environment. The Postdoctoral Fellow will contribute to the project by expressing and characterizing enzymes and testing gene combinations for their chemical output. Experience with membrane-bound proteins would be beneficial. The preferred candidate will also have good communication and organizational skills.Further information can be obtained from Professor Emily Parker ([email protected])Please complete the online application form and submit your CV (including the names of a least two academic referees) and cover letter by attachment athttp://www.victoria.ac.nz/about/careers/current-vacanciesApplications close Sunday, 31 March 2019.Victoria University of Wellington is an EEO employer and actively seeks to meet its obligations under the Treaty of Waitangi.For more information and to apply online visit http://www.victoria.ac.nz/about/careers/current-vacanciesReference 2713

8379| Victoria University of Wellington, Ferrier Research Institute| Postdoctoral Research Fellow in Synthetic Biology| We are seeking applications for a Postdoctoral Fellow to join the Ferrier Research Institute at Victoria University of Wellington as part of an Endeavour Fund Project funded by the Ministry of Business, Innovation and Employment. This project involves contributing to our Synthetic Biology work by using molecular biology and analytical chemistry techniques to examine fungal biosynthetic pathways for the generation of high-value natural products.The position will be for a term of two years (full-time) starting in early to mid-2019. The fellow will have the opportunity to contribute in project planning, as well as co-supervision for PhD students.The Postdoctoral Fellow will contribute to the project by isolating fungal natural products, determining suitable biosynthetic routes for their manufacture, and using molecular biology techniques to construct new pathways. The ideal candidates will have a PhD in Biology or Chemistry, have demonstrated the understanding of natural products biosynthesis, analytical techniques, molecular biology, and/or fungal genetics, and have the ability to apply this knowledge to create biological systems that support the manufacture of bioactive compounds.Further information can be obtained from Professor Emily Parker ([email protected])Applications close on Saturday, 23 March 2019.Victoria University of Wellington is an EEO employer and actively seeks to meet its obligations under the Treaty of Waitangi.For more information and to apply online visit http://www.victoria.ac.nz/about/careers/current-vacanciesReference 2675.

8415| UKRI Medical Research Council, Laboratory of Molecular Biology| Postdoctoral Scientist - Structural Studies - Dr David Barford - LMB 1060| Postdoctoral Scientist – Structural StudiesStarting Salary £30,914 - £33,755 per annum 3 Years Fixed TermMRC Laboratory of Molecular Biology, Cambridge, UKWe seek to appoint a Postdoctoral Scientist to the Division of Structural Studies to undertake single particle electron cryo-microscopy (cryo-EM) analysis of multi-subunit complexes that regulate the cell cycle, specifically the mechanism of chromosome segregation. The project will also include electron cryo-tomography to investigate structures in situ. This position is located at the MRC Laboratory of Molecular Biology in Cambridge, UK within the group of David Barford. The project would suit a highly motivated and committed Scientist interested in molecular mechanisms of the cell cycle.For further information, please visit:http://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/david-barford/The successful applicant will hold at least a PhD (or equivalent) in a biological/physical science. Experience with either single particle electron microscopy or electron cryo-tomography is essential. The post is available from 1st July 2019. Informal enquires may be made to David Barford ([email protected])The successful applicant will be awarded a 3 year Career Development Fellowship / Postdoctoral training Scheme position. This is a training and development position for a Post-doctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org.Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare facilities.To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/1176.If you are unable to apply online please contact us at [email protected] date: 17 April 2019Final appointments will be subject to a pre-employment screening.The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme.

8418| Quadram Institute Bioscience, Gut Microbes and Health| Research Scientist (Ecological Networks)| Research Scientist (Ecological Networks) Applications are invited for a Research Scientist to join the Laboratory of Dr Falk Hildebrand in the Gut Microbes and Health Programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.Background:The Hildebrand group is working on microbial communities, bacterial strain evolution and genome plasticity, with the ultimate goal of understanding the microbial aetiology of a broad range of human diseases. The group is specialised in developing novel methods that merge metagenomics, evolution, species interactions, characterising unknown microbes.The role:The position will be computational, offering flexibility and opportunities for personal development. The post holder will contribute to supervising students and to grant and manuscript writing. The post holder will research microbial communities (human gut), to understand bacterial dependencies, their metabolism and investigate the ecological role in relation to human well-being. This 3-year funded position will give the applicant the opportunity to have an active role in building a new research group, offering independence, responsibility and scientific freedom.The ideal candidate:The applicant holds a PhD degree related to Computer Science, Ecology or Microbiology and has expertise in numerical ecology, having worked with co-occurrence networks, probabilistic acyclic graphical methods or other community centric methods, such as enterotypes. They are acquainted with temporal and/or microbial data, (bacterial) metabolism and genome scale metabolic models. The candidate should be proficient in either Perl/C++/R/Python and the use of a Linux operated high performance computing environment. Wet lab experience will be considered a plus. The applicant is expected to work independently and have good communication skills.Additional information:Salary on appointment will be within the range £31,250 to £38,100 per annum depending on qualifications and experience. This post is for a contract of 3 years with a possibility of further extension. For informal enquiries please contact Dr Falk Hildebrand by email at [email protected] For further information and details of how to apply, please visit our web site https://jobs.quadram.ac.uk or contact the Human Resources team on 01603 450462 or [email protected] quoting reference 1003654.Interviews will be held on 3 May 2019. Further information about living and working in Norwich can be found here https://quadram.ac.uk/about/join-us/ We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work.As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. About the Quadram Institute:The Quadram Institute is a new interdisciplinary research institute at the forefront of a new era in food and health research. Its mission is to understand how food and the gut microbiota are linked to the promotion of health and the prevention of disease. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a new state-of-the-art building. The Quadram Institute is based on the Norwich Research Park, one of Europe’s largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. (https://quadram.ac.uk/).The closing date for applications will be 23 April 2019. The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.

8403| Institute of Cancer Research, Molecular Pathology| Postdoctoral Training Fellow in Tracking Clonal Evolution in Colorectal Cancer| The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer. We seek a highly motivated Postdoctoral Training Fellow to join the Sottoriva Lab within the Centre for Evolution and Cancer at The Institute of Cancer Research in London (ICR), and work on tracking clonal evolution in colorectal cancer using longitudinal sampling of both patients and model systems. The Sottoriva Lab (www.sottorivalab.org) focuses on deciphering the mechanisms of cancer progression and treatment resistance in each patient using a rigorous mathematical approach, with the objective of anticipating the future course of the disease. We tackle cancer as a complex system, using rational tissue sampling and cancer genomics as the basis for data generation. We integrate the data with mathematical and computational models of tumour evolution, with the aim of formulating clinically-driven hypotheses and test predictions that will impact the way we treat cancer. In this project, we sample and profile human colorectal malignancies from clinically annotated cohorts using multi-region and longitudinal sampling. We also follow the evolution of colorectal cancer over time using in vitro and ex vivo model systems. We analyse the data with state-of-the-art bioinformatics techniques and novel statistical methods. We then integrate the results with mathematical and computational models of colorectal cancer progression and treatment resistance, with the aim of making predictions on the evolution of a tumour. The successful candidates will focus on understanding and tracking clonal evolution of colorectal cancer at the genomic and epigenomic levels, both from human samples such as circulating tumour DNA (ctDNA), and from model systems. The responsibilities include the development of mathematical models of tumour evolution and drug resistance, and the analysis of whole-genome, whole-exome, targeted sequencing and methylation data. The successful post will have the opportunity to interact within a multidisciplinary environment of molecular biologists, clinicians, computer scientists and mathematicians. They will have the opportunities to learn about latest approaches to deconvolute the complexity of cancer evolution and will explore new research areas in medicine.The new Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future. The position is offered on a 3 year fixed term contract. The full salary range for the post is £31,023 - £44,337 p.a. inclusive. Starting salary on the scale will be based on previous postdoctoral experience. Informal enquiries can be made to Dr Andrea Sottoriva ([email protected]). Please DO NOT send your application via email, formal applications must be submitted online. Please click below to apply.

8386| Institut Fresnel, Aix Marseille University| Metrology of light scattered by optical components for LISA project| * Scientific contextLISA, Laser Interferometer Space Antenna, is a space-borne Gravitational Wave Observatory with an arm-length of 2.5 million km, compared to the few km’s of the ground-based observatories. LISA is the largest project ever led by ESA, with the support of NASA and all the European national Space Agencies. LISA will be a Space interferometer with 3 arms of 2.5 million km length. The 3 satellites with optical payloads will be launched in 2034 to fly in formation on the same orbit than the Earth. Due to the distances and the configuration of the interferometer, the performances of the instrument will be mainly limited by the straylight, which is a critical point in this project and an ambitious technical and scientific challenge.In this context, as the international leader of this straylight field, the Institut Fresnel has been asked to join the LISA Consortium to take the charge of the modeling and metrology of straylight at the component level.The Institut Fresnel is now active part of the LIG (LISA Instrument Group) and SLWG (Straylight Working Group). New numerical and experimental developments will be brought by the laboratory on the basis on the expertise of the CONCEPT Group and DIFFUSIF Platform.* MissionThe post-doc will work on the DIFFUSIF platform of the Institut Fresnel. He / She will be in charge of the activities of the DIFFUSIF platform as part of the LISA project.* Activitieso He / she will be in charge of the development of a test bench for the accurate coherent and incoherent measurement of light backscattered by optical components (mirrors, beamsplitters, lenses, etc ...) designed for the optical systems that will be embedded on the LISA satellites.o He / she will be in charge of the different series of measurements to be carried out by the platform as part of the LISA project.* Expertise / skills- Technical skillso Optical metrologyo Optical instrumentationo Parasitic light, straylight and scatteringo Interferometryo Contamination / Clean roomo Metrology of low noise optical systems specific to gravitational wave detectiono Constraints specific to instrumental developments for space projectso Quality procedures in the space domain- Operational know-howo Constraints specific to instrumental developments for space projectso Quality procedures in the space domain.- Other skillsThe practice of English (read, spoken, written) is required:• The drafting of documents, reports and articles, in English will be recurrent• He/She will have to present the results to the international consortium and in international conferencesAdministrative procedures (purchase of equipment, security ...)*Working environmentThe engineer will be attached to the technological platform of Aix-Marseille University DIFFUSIF located at the Institut Fresnel on the campus of Saint Jérôme. He/She will join the LISA community through the Institut Fresnel participation. More details are available here: https://www.fresnel.fr/spip/spip.php?article2228The position is funded by the Aix-Marseille Initiative of Excellence, A*Midex. Aix-Marseille University has been awarded the Initiative of Excellence national label as part of the Investments for the Future Programme (PIA). A*Midex is led by Aix-Marseille University, with seven partners: CNRS, Inserm, CEA, IRD , AP-HM, Sciences Po Aix, and Centrale Marseille. The objective of A*Midex is to enhance and develop the exceptional potential of Aix-Marseille University and its area by providing them with world-class research and higher education. The Institut Fresnel and DIFFUSIF were selected in the frame of the A*Midex programme “Talents Management” dedicated to attract high-level research engineers in Aix-Marseille. More information on the A*MIDEX foundation can be found at: https://amidex.univ-amu.fr/en* Specific conditions : Candidates must have had no contractual relationship with Aix-Marseille University over the last 5 years.* To apply : Please send CV, motivation letter and recommendations letters from previous advisors to [email protected] Online offer : https://www.fresnel.fr/spip/spip.php?article1948

8414| KAUST, Bio-Ontology Research Group (BORG)| Postdoctoral researcher in Biomedical Data Science| We are looking for a researcher to join us in the Bio-Ontology Research Group (BORG) at the Computational Bioscience Research Center (CBRC) at King Abdullah University of Science and Technology (KAUST) in Saudi Arabia. The BORG, headed by Professor Robert Hoehndorf, is known for pioneering several methods that utilize formal ontologies and logics for data analysis in life science. The group is developing some of the world’s leading systems for protein function prediction, finding gene-disease association, and identifying causative variants in genomic sequences. Get to know us: Video: https://www.youtube.com/watch?v=202reah3s_4Website: https://borg.kaust.edu.sa/ Whom are we looking for exactly? We are looking for researchers who have completed their Ph.D. in the past four years, or will complete their Ph.D. in the next six months, and who have an ambition to advance their academic career through world class research in data science with a focus on the life sciences. Successful candidates will have experience, demonstrated by publications in leading conferences or journals, in the development or application of methods in data science or artificial intelligence with focus on biology or biomedicine. In addition, candidates will be able to develop and implement data analysis methods that can utilize very large datasets such as those available in life sciences. What are the requirements for the positions? • A completed Ph.D. degree (in Computer Science or related), completed in the last 4 years. • Proficiency in spoken and written English. • Experience, demonstrated by a publication record, in one of the following areas: • Machine Learning, Data Mining, Statistics, Data Science • Semantic Technologies and Ontologies, Knowledge Representation, Formal Logic • Development of novel methods in Bioinformatics or Biomedical data analytics What can we offer? • A dynamic work environment in a young research group focusing on applications of Artificial Intelligence in life sciences. • Access to world-class compute infrastructure, including the Shaheen 2 Cray XC40 supercomputer, and dedicated machine learning systems. • Access to unique samples and datasets that enable us to address some of the most challenging problems in biology and medicine. • An international, highly diverse university campus and housing by the Red Sea, with activities ranging from relaxing at the beach to golfing to diving with whale sharks. • A competitive salary (commensurate with the applicant's qualifications), free, fully-furnished housing on the KAUST campus (with less than 10 minutes travel time to and from work), free medical and life insurance, and free education at KAUST School for thepostdoctoral researcher’s children. KAUST will be responsible for the actual recruiting decision, appointment offers and employment benefits. How to apply: To apply, please send an email to Robert Hoehndorf ([email protected]) including a brief motivation letter, CV, and the names and contact details of two references. Please use "Application for postdoctoral position in Biomedical Data Science" as subject of your email.

8417| RWTH Aachen University, Institute for Molecular Cardiovascular Research (IMCAR)| Postdoctoral Fellow (m/f/d) Immune-Lipid Crosstalk| The position is a full-time position (38,5 h/w) and is project-related funded until the 31st of December 2021 with the option of extension. The salary corresponds to level 13 TV-L.It has been recently shown that chronic kidney disease (CKD) patients have an increased risk for cardiovascular disease (CVD), although the precise underlying mechanisms remain elusive.Candidates will perform research to explore the contribution of a novel mechanism of immune-lipid crosstalk, which might explain at least partly the observed increased CVD risk in CKD-patients. Hereby, the focus will be to investigate the interference of high-density lipoproteins (HDL) and other lipids with the chemokine-receptor signaling and its functional consequences.Candidates will be working with a wide variety of both in-vitro and in-vivo (mouse) models. The working language of the group is English.The candidate should hold a PhD in Biology or Biomedical Sciences.The RWTH Aachen University is certified as a family-friendly university and offers a dual career program for partner hiring. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH Aachen University. The principles of fair and open competition apply and appointments will be made on merit.Interested candidates should send a brief motivation letter, CV and the names of two references (code-no: GB-P-16536 by April 26th, 2019) to [email protected]

8393| The Institute of Cancer Research (ICR), Radiotherapy and Imaging| Postdoctoral Training Fellow - Magnetic Resonance Team| he Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.The pre-clinical magnetic resonance team, led by Dr. Simon Robinson, is focused on the application of both established and innovative, quantitative functional MRI techniques to identify case-specific imaging biomarkers in models of cancer in vivo, thereby establishing their utility to correctly inform on i) the pathology and processes relevant to a particular cancer type, and ii) response/resistance to treatment against these processes. There is a strong emphasis on the development of quantitative MRI biomarkers that can be realistically translated and prove informative in aligned imaging investigations of cancer patients. Through new programme grant funding from Cancer Research UK, an early-stage post-doctoral training fellow position is available to exploit MRI for adaptive radiotherapy in pre-clinical models of cancer. We are looking for a highly motivated and creative individual to first establish MRI-guided radiotherapy on a small animal radiation research platform (SARRP), and secondly evaluate the utility of MRI-derived biomarkers of hypoxia to predict tumour radiation response, and their potential use in enhancing radiotherapy efficacy.The position will be based within the Centre for Cancer Imaging, which provides an integrated environment for multi-modality pre-clinical imaging, co-locating a pre-clinical 7T MRI system with a SARRP. The position will provide opportunities to interact within a multidisciplinary environment of staff within imaging, radiotherapy, drug development and molecular pathology teams, and explore new avenues of research.Applicants should possess a PhD in physical or biomedical science, and ideally demonstrated excellence in the field of in vivo pre-clinical radiobiology, as evidenced by peer-reviewed publications and productivity during their PhD studies. Appointment will be on a Fixed Term Contract for 3 years in the first instance.Informal enquires are welcome and can be made to Dr. Simon Robinson ([email protected]). Please note that formal applications must be submitted online by clicking on the 'Apply' button below.

8399| University of Bern, Department of Biomedical Research| Postdoc Position: Molecular Biology of CRISPR-Cas9 and Long Noncoding RNAs| Are you a molecular biologist who loves the challenge of developing new methods?Then the “Genomics of Long Non-Coding RNAs in Disease” Laboratory (GOLD Lab) has an opportunity for you!The Project: Understanding how long noncoding RNA (lncRNA) functions are encoded in their sequence is a great challenge in biology. Our goal is to discover, classify and characterise lncRNA functional elements by means of an integrative bioinformatic / experimental approach. You will lead an experimental project to develop novel methods, based on CRISPR-Cas9, to dissect lncRNA functionality. Work will benefit from close collaboration with our team of experimentalists and computer scientists with wide experience in genome engineering. The Group: We are a diverse and interdisciplinary team of researchers with a passion for lncRNA research. We foster an open and collaborative working environment. Our work is funded by the Swiss National Center for Competence in Research (NCCR) “RNA & Disease” (nccr-rna-and-disease.ch) project, providing numerous links with other RNA researchers. We also participate in GENCODE and the International Cancer Genome Consortium (ICGC). We enjoy clinical collaborations at the University Hospital of Bern. For more information about us see gold-lab.org and twitter.com/goldlab_bern.The Person: We seek a dedicated and dynamic colleague to join our team. The project will be strongly focused on developing new CRISPR-Cas9 techniques, so you should have solid experience in some of: molecular biology, RNA biology, method development, innovative thinking. CRISPR-Cas9 experience is helpful but not strictly necessary.Details: Ideal start date will be Q1 of 2019. Project is fully funded for at least 3 years. Salary is according to (generous) University of Bern scales.The City: Bern, the capital of Switzerland, is well connected at the heart of Europe, has a vibrant international community, numerous outdoors and cultural activities, and ranks among the best cities worldwide for quality of life (https://tinyurl.com/y9vrtb7d).Recent publications:Esposito et al Cancer Cell. 2019 Feb 14. pii: S1535-6108(19)30053-4.Carlevaro-Fita et al. Genome Res. 2019 Feb;29(2):208-222.Uszczynska-Ratajczak B et al. Nat Rev Genet. 2018 Sep;19(9):535-548. doi: 10.1038/s41576-018-0017-y. Lagarde J et al. Nat Genet. 2017 Dec;49(12):1731-1740. doi: 10.1038/ng.3988. To apply: Please send a brief email explaining how you fit the project description, publications list, and CV to rory.johnson[at]dbmr.unibe.ch with subject title: “Job application SNF Postdoc”. Informal enquiries are also welcome. The position will be advertised until filled, and latest updates on the job availability will be posted at www.gold-lab.org/we-are-hiring, so please check before applying. 05/03/2019

8385| Agri-Food and Biosciences Institute Northern Ireland (AFBI)| Principal Scientific Officer - Plant Biology AFBI Crossnacreevy| REF: IRC239235SALARY: £48,226 - £52,857 (under review)DEPARTMENT: Agri-Food and Biosciences Institute Northern Ireland (AFBI)LOCATION: AFBI Crossnacreevy, 50 Houston Road, Crossnacreevy, BelfastAn exciting opportunity is currently available for an enthusiastic scientist with internationally recognised expertise in the area of plant biology. AFBI has a key role in supporting agri-food production in Northern Ireland and with plants playing an important role in the supply chain, AFBI is seeking to recruit a Principal Scientific Officer to lead on plant biology research in collaboration with plant, animal and environmental scientists across the Institute. The post holder will also be the Chief Seed Testing Officer and will manage the Official Seed Testing Service in Northern Ireland, which is based in AFBI, Crossnacreevy, as well as its associated resources and staff. This is an important Principal Investigator position within AFBI and will play an important role in delivering future research and resilience for the NI Agri-Food industry.Further appointments may be made from this competition should AFBI positions become vacant which have similar duties and responsibilities.For more detailed information and to apply, please go to www.nicsrecruitment.org.ukAlternatively, an application pack can be requested by contacting:HRConnect, PO Box 1089, The Metro Building, 6-9 Donegall Square South, Belfast, BT1 9EW. Telephone: 0800 1 300 330. Email: [email protected] requests must include your name, address and reference number IRC239235.Completed application forms must be returned to arrive not later than 12:00 noon (UK time) on Friday 5th April 2019.Applications are particularly welcomed from Roman Catholics and Females as these groups are currently under-represented within AFBI.AFBI is an Equal Opportunities EmployerALL APPLICATIONS FOR EMPLOYMENT ARE CONSIDERED STRICTLY ON THE BASIS OF MERIT

8404| University Health Network / University of Toronto, Princess Margaret Cancer Centre| Postdoctoral fellow| A POSTDOCTORAL position is available in the laboratory of Dr. Hakem at the Princess Margaret Cancer Centre / University Health Network / University of Toronto, , Toronto, Canada. The Hakem lab’s research program focuses on understanding the mechanisms of cancer and the identification of novel therapeutic strategies for cancer. The lab has excellent track records studying in vivo cancer mechanisms and signaling pathways. These studies include in vivo functions of BRCA1, P53, MUS81, RNF8, RNF168 and CHK2 (Nature Immunol., 1: 77-82; Genes & Dev, 18: 1144-1153; Science, 304: 1822-1826; JEM. 207: 983-97, J Clin Invest. 128: 4525-4542; PNAS 110: 20982-7; Nature Communications, DOI: 10.1038/ncomms 12638). Our studies are based on genetic, proteomic, transcriptomic, bioinformatics, molecular analyses in human cancer cell lines and mouse models, as well as data from cancer patients. Genome-wide CRISPR-Cas9 screening is also used.Candidate requirements:- PhD or MD/PhD degree obtained within the past 3 years- Demonstrated expertise in cell signaling and molecular biology- Highly self-motivated and creative individual with strong First author publications - Excellent writing and communication skills- Ability to work effectively both independently and as a member of a team is a prerequisite.Interested applicants should submit their C.V., names of three referees and a statement of research interest to Dr. Hakem ([email protected]).

8412| University College Dublin, UCD School of Electrical and Electronic Engineering| Senior Power Systems Researcher, UCD School of Electrical and Electronic Engineering (Temporary 36 month appointment)| Applications are invited for a temporary post of a Senior Power Systems Researcher within UCD School of Electrical and Electronic Engineering.This research is part of a new project led by UCD Energy Institute with the support of the Department of Communications, Climate Action and Environment called EMPowER. The Emissions and Fuel Mix, Markets and Costs, Power Flows and Networks, and End Use & Rates of Uptake (EMPowER) modelling framework combines policy and electricity demand modelling with power system and market modelling. This research marshals existing competencies across the disciplines of economics, engineering, power systems, and policy to apply comprehensive energy and emissions modelling to policy questions and respond to analytical needs as they arise. The successful candidate will join a team of researchers within the UCD Energy Institute. They will lead the distribution network modelling pillar of the EMPowER project. The aim of the particular research project is to understand and develop a theoretical and empirical model of distribution networks in Ireland. The project will use the model to advance evidence-based policy recommendations on climate change mitigation and electricity policy in Ireland. Salary Range: €50,000 - €54,000 per annum Appointment on the above range will be dependent on qualifications and experienceClosing date: 17:00hrs (local Irish time) on 3rd April 2019.Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/. UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.

8422| The Institute of Photonics Sciences| Post-Doctoral Position in Quantum Chemistry for Nanophotonics| ICFO is offering a postdoctoral position to a well-qualified, highly motivated, and dynamic young scientists who wish to enhance her/his scientific career in a friendly and stimulating environment. The successful candidate will be joining the Nanophotonics Theory Group led by Prof. Javier García de Abajo. The group has extensive theoretical experience in the fields of Nanophotonics, Electron Microscopy, and Quantum Physics, combining elements of Condensed-Matter Theory, Quantum Chemistry, Quantum Optics, Atomic Physics, and Advanced Electromagnetism to predict and explain fundamentally new physical phenomena. More information and full access to recent publications by the host group can be obtained as http://www.nanophotonics.es/. This project is part of the Advanced ERC Grant e-Nano held by the group leader.ELIGIBILITY AND CONDITIONSCandidates must hold an internationally recognized PhD degree (or evidence of its completion in the nearest future) based on theoretical work, preferably in the areas of Condensed-Matter Physics, Quantum Chemistry, Materials Science, or Atomic Collisions. Experience in the fields of Plasmonics, Electron Microscopy, Surface Science, and/or Atomic Collisions will be valued, although it is not a prerequisite for this position.We seek a highly-motivated candidate with theoretical experience in first principles simulations of molecular systems and nanomaterials. The candidate should have a proven track record in the computational study of the structural and optical properties of different materials and/or molecular systems using ab initio methods. The use of different calculation schemes (DFT and post-DFT for structural simulations, and TDDFT and Bethe-Salpeter for the optical response) will be highly valued. The candidate should be familiarized with state-of-the-art techniques and codes in order to carry out such calculations for selected solid surfaces, nanowires, and molecular systems, as well as combinations of these elements. The work carried out by the candidate will be part of a high-impact research project to incorporate detailed atomic insight into the optical response of different nanomaterials, as well as their interactions with free electron beams. Further details of the project will be discussed during an interview.ICFO is an equal employment opportunity employer. Candidates are selected exclusively on merit and potential on the basis of submitted application material. No restrictions of persons with disabilities, citizenship or gender apply to ICFO positions. ICFO abides by the principles of openness, efficiency, transparency, supportiveness, and international comparability as stated in the European Charter for Researchers and the European Code of Conduct for the Recruitment of Researchers.The contract is offered for periods of one year, renewable for a total of up to 3 years.APPLICATION PROCEDUREThe formal application should be submitted online via http://jobs.icfo.eu/?detail=420.Suitable candidates are requested to submit:- Presentation letter with a declaration of interest,- Curriculum Vitae, including contact details,- The contact e-mail of two potential referees.Candidates may contact [email protected] for informal enquiries regarding the application, as well as address scientific enquiries to [email protected] call will remain open until May 15, 2019. For updated information about ICFO, please visit http://www.icfo.eu/ For updated information about the host group, please visit http://www.nanophotonics.es/

8416| Ariel University, Department of Chemical Sciences| Experimental and coputational study of energy conversion and storage reactions and materials| The fuel cells and electrochemistry laboratory at the Department of Chemical Sciences at Ariel University in Israel is seeking postdoctoral candidates to conduct applied, computational and analytical investigation in the field of catalysis, surface chemistry, energy conversion & storage materials. The candidate will join a well-established enthusiastic group of scientists under the supervision of Prof. Alex Schechter and will join the effort to explore the physical, chemical and catalytic properties of transition metal catalysts and support materials for fuel-cell applications, hydrogen generation /storage as well as other interfacial electrochemical challenges. This research is expected to lead to highly active functional materials and fundamental understanding of their role via rigorous study of their reactions mechanism on practical and theoretical levels. The proposed position is supported by the Israeli science foundation, under a national renewable energy program. Ariel University offers a collaborative research environment and features state-of-the-art research facilities relevant to the proposed position. A full competitive scholarship and subsidized accommodation are offered to prospective candidates in this program. Required Qualifications: A successful PhD degree in Chemistry, Chemical Physics, Chemical Engineering or Material Sciences, journal publications record. Preferred Qualifications: former studies and experience in nanomaterials, electrochemistry, computational methods (G09, VASP), Polymer science and relevant analytical methods (FTIR, XPS, XRD, HRTEM, Raman microscopy).For more information about this position, please contact Prof. Alex Schechter at [email protected]

8382| Albert Einstein College of Medicine, Genetics| Postdoctoral Position Available in Microbes, Biofilms and C. Elegans| The Mani Laboratory @The Albert Einstein College of Medicine, INC has an open position for a highly motivated postdoctoral fellow to be part of an expanding research program on novel aspects of the microbial biofilms and C. elegans inflammation and aging. This position is being filled in conjunction with The Nudler Laboratory at NYU and will benefit significantly from the collaboration of both laboratories.Laboratory Research Focus and Expertise: The laboratory is focused on the study of orphan nuclear receptors, specifically the Pregnane X Receptor (PXR), that recognize xenobiotics (and endobiotics) as ligands and their effects on mammalian physiology and pathophysiology. Recently, we have shown that microbial metabolites can serve as ligands for such receptors (Immunity, 2014). In more recent work, in the study of these microbial ligands, we devised a biofilm assay that allowed for identification of new and novel bacterial species/strains from the enteric microbiota. The goal now is to study all aspects of the importance of these species to host physiology and pathophysiology (inflammation, cancer). These studies will include delving into the mechanisms of host-microbe (and microbe-host) interactions using C. elegans as a model organism. Related research can expand to study of the mechanisms of bacterial biofilms using both genetic, biochemical and biophysical approaches. SEE: http://www.einstein.yu.edu/faculty/5615/sridhar-mani/SEE: http://nudlerlab.info/lab/ AND https://www.hhmi.org/scientists/evgeny-nudler Postdoctoral Expertise Required: 1. Recent doctoral degree or equivalent (e.g., M.D or M.D./Ph.D or Ph.D) and/or early postdoctoral training exposure.2. First author publication record from Ph.D 3. Experience in C. elegans and biochemistry research. 4. Strong reasoning, communication, visualization and written skills (English) are preferredPlease e-mail your CV and cover letter focusing on your interests and goals, along with contact information (and/or letters) from three referees to: [email protected] OR [email protected]

8383| King Abdullah University of Science and Technology (KAUST)| Postdoctoral position in Label-free imaging based on broadband Coherent Raman micro-spectroscopy| A postdoctoral research position is immediately available in the Vibrational Imaging group, headed by Prof. Carlo Liberale, in the Biological and Environmental Sciences & Engineering Division at King Abdullah University of Science and Technology (KAUST, Saudi Arabia). The Liberale group is a multidisciplinary team of physicists, engineers and biologists committed to the development and application of new-generation label-free microscopy methods for biomedical research. The laboratory is equipped with cutting edge instruments and technology in the field of vibrational micro-spectroscopy. Additionally, KAUST offers exceptional infrastructure for scientific research and is equipped with state-of-the-art core facilities for imaging, characterization and micro-\nano-fabrication.We are looking for an ambitious and self-motivated post-doctoral researcher to work on the development and application of a novel fast and broadband Stimulated Raman Scattering microscopy system, in the framework of a recently awarded grant and of an interdisciplinary project investigating lipid dysregulation in cancer cells.A Ph.D. degree in engineering, physics, or a related field is required. The candidate must have hands-on experience with optical instrumentation, optical microscopes and ultrashort pulse laser sources. Proficiency using Matlab and LabVIEW is preferred. Experience in image analysis and Multivariate Analysis of spectroscopic data will be considered a plus. The offered appointment is a full-time research position with a two-year contract.A highly competitive tax-free salary is provided. Benefits: free housing; relocation support; health insurance; one round-trip airline ticket per year to visit home country.Applications should include: - CV- cover letter that summarizes the research experience and areas of interests of the applicant- academic transcripts (unofficial/scanned is acceptable)- contact information of at least 2 academic references. Applications should be sent to [email protected] postdoctoral position will be open until filled.

8421| The Institute of Photonic Sciences| Post-Doctoral Position in Electron-Beam Spectroscopy for Nanophotonics| ICFO is offering a postdoctoral position to a well-qualified, highly motivated, and dynamic young scientists who wish to enhance her/his scientific career in a friendly and stimulating environment. The successful candidate will be joining the Nanophotonics Theory Group led by Prof. Javier García de Abajo. The group has extensive theoretical experience in the fields of Nanophotonics, Electron Microscopy, and Quantum Physics, combining elements of Condensed-Matter Theory, Quantum Chemistry, Quantum Optics, Atomic Physics, and Advanced Electromagnetism to predict and explain fundamentally new physical phenomena. More information and full access to recent publications by the host group can be obtained as http://www.nanophotonics.es/ This project is part of the Advanced ERC Grant e-Nano held by the group leader.ELIGIBILITY AND CONDITIONSCandidates must hold an internationally recognized PhD degree (or evidence of its completion in the nearest future) based on theoretical work, preferably in the areas of Plasmonics, Nanophotonics, Electron Microscopy, Condensed-Matter Physics, Quantum Chemistry, Materials Science, or Atomic Collisions.We seek a highly-motivated candidate with theoretical capabilities in the simulation of electromagnetic phenomena. Experience in the following areas will be highly valued: interaction of radiation with atoms/molecules, interaction of electron beams with nanomaterials, nonlinear optics, quantum optics, fluctuation phenomena, and/or numerical solution of Maxwell’s equations. The candidate should be familiarized with state-of-the-art techniques and codes to produce numerical solutions of the Maxwell equations. The project will heavily rely on such solutions, as well as their application to explore new phenomena associated with the interaction of electron beams with nanomaterials, as mediated by the electromagnetic field. Quantum aspects of such interaction will be also pursued. The work to be carried out by the candidate will be part of a high-impact research project in the context of the abovementioned Advanced ERC Grant. Further details of the project will be discussed during an interview.ICFO is an equal employment opportunity employer. Candidates are selected exclusively on merit and potential on the basis of submitted application material. No restrictions of persons with disabilities, citizenship or gender apply to ICFO positions. ICFO abides by the principles of openness, efficiency, transparency, supportiveness, and international comparability as stated in the European Charter for Researchers and the European Code of Conduct for the Recruitment of Researchers.The contract is offered for periods of one year, renewable for a total of up to 3 years.APPLICATION PROCEDUREThe formal application should be submitted online via http://jobs.icfo.eu/?detail=421.Suitable candidates are requested to submit:- Presentation letter with a declaration of interest,- Curriculum Vitae, including contact details,- The contact e-mail of two potential referees.Candidates may contact [email protected] for informal enquiries regarding the application, as well as address scientific enquiries to [email protected] call will remain open until May 15, 2019. For updated information about ICFO, please visit http://www.icfo.eu/ For updated information about the host group, please visit http://www.nanophotonics.es/