Two postdoctoral researchers to study microRNA functions in single cells

Institutions
Science for Life Laboratory (SciLifeLab) is a collaboration between four universities in Stockholm and Uppsala: Stockholm University, the Karolinska Institute, the Royal Institute of Technology, and Uppsala University. The SciLifeLab is a national center for large-scale biosciences with a focus on high-throughput health and environmental research. The center combines advanced technical know-how and cutting-edge equipment with a broad knowledge in translational medicine and molecular biosciences. In particular, SciLifeLab has in the recent years become an international hub for research in single-cell and spatial transcriptomics.
Stockholm University is a leading European university offering a multicultural environment in one of the world’s most dynamic capital cities. With more than 60,000 students and 5,000 staff, the University facilitates individual and societal development by providing top quality education that is tightly linked to its internationally recognized research programs. The MBW department conducts experimental basic research in molecular cell biology, integrative biology and infection and immune biology.

Research project
The postdoctoral positions are available in the Quantitative RNA Biology group headed by associate professor Marc Friedlander, part of MBW and located at the SciLifeLab. The group is part of a larger vibrant international collaborative environment and seeks to address fundamental questions in RNA biology, by applying quantitative approaches such as single-cell RNA sequencing, single-cell proteomics, various high-throughput screening methods and advanced computational biology.
Recent collaborations include paleotranscriptomic profiling of mammoth non-coding RNAs and study of the impact of space flight on the human transcriptome (NASA Twin study). The main focus of the group is to study microRNA functions in mammalian single cells, investigating the impact of microRNAs on target gene expression variation, covariation and on overall gene expression networks. This research direction is funded by an ERC Starting Grant (miRCell 758397).
The postdoctoral researchers will develop beyond-state-of-the-art methods to profile the variation of microRNA expression, interactions between microRNAs and their targets, and the impact of microRNAs on the transcriptome and proteome, in single cells. The post docs will interact with experimental and computational researchers from the group, and will participate in limited co-supervision of PhD students.
Lab website: www.friedlanderlab.org
Twitter: www.twitter/friedlanderlab
Recent pre-print on gene covariance: www.biorxiv.org/content/10.1101/771402v1
Recent pre-print on single-cell proteomics: www.biorxiv.org/content/10.1101/749473v3

Eligibility
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country.

Selection criteria
In the appointment process, special attention will be given to research skills. We are looking for candidates that have extensive wet-lab experience with transcriptomic or proteomic methods, preferably in a single-cell context. Specific experience with single-molecule FISH, microfluidics, oligo-assisted proteomics, PEA or PLA constitutes an additional advantage. Familiarity with the microRNA field is not necessary, however the candidates must be highly motivated, creatively thinking and have a record of high-quality scientific publications. Excellent English language skills, both written and spoken, are a requisite.

Terms of Employment
This is a full-time position available immediately. The starting date is negotiable. The position is initially funded for two years, with a possibility of extension. The position constitutes full employment including all social benefits. Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact
Further information can be provided by associate professor Marc Friedlander, [email protected]

Application
Applications should be submitted until the 16th of November using the Stockholm University web-based application system at: https://www.su.se/english/about/working-at-su/jobs?rmpage=job&rmjob=10155&rmlang=UK
The instructions for applicants are available at: https://www.su.se/english/about/working-at-su/instructions-applicants

You are welcome to apply!
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