The University of Toronto is consistently rated as one of the top research institutes in the world. As a member of the largest research-based university in Canada, you will be at the forefront of innovation. You will be an integral member of a community that is changing the world.
The Salmena lab is seeking an independent and motivated postdoctoral fellow to start immediately. on a newly funded project. Our ongoing scientific interests include investigations of perturbations in phosphoinositide signalling and consequences for leukemia development. We use mouse models of human and murine leukemia to investigate therapy targets, chemoresistance and leukemic stem cell biology, thus experience in animal handling, transplantations and leukemia biology will be an asset. Current projects include the characterization of novel genes involved in leukemogenic stemness and therapy resistance.
By joining our team you will be part of a group of young motivated scientists with ambition for academic excellence and scientific discovery. Our goal is to maintain a productive and collaborative learning environment while striving to enjoy scientific life as a team.
The position will commence with a 1 year contract with the option of further extension.
Projects
• Identify genetic networks in the regulation of leukemia stem cell activity
• Understand the mechanisms of developing and overcoming therapy resistance
Required Qualifications
• PhD in Molecular or Cell Biology, Biochemistry or equivalent
• expertise in basic cell, molecular and biochemical techniques (western blotting, immunoprecipitations, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
• Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques
• Experience and high motivation to work with mice and primary patient cells
• Rapid understanding and independent analysis of complex data
• Experience in writing scientific reports and papers
• Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, GraphPadPrism, R, BLAST)
• Strong communication skills (oral presentations and writing)
• Fluent English, both in written and spoken
Contact & Application
Please include a CV, cover letter, a complete list of publications and 2 – 3 references to
[email protected]
