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Postdoctoral Scientist - Neurobiology - Dr Anne Bertolotti - LMB 872



Postdoctoral Scientist – Neurobiology
Starting Salary £30,464 - £33,305 per annum
MRC Laboratory of Molecular Biology, Cambridge UK

The MRC Laboratory of Molecular Biology is a world leader in biological research, with an expanding scientific programme dedicated to understanding gene function in health and disease. It provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world, creating a lively and international community for the exchange of ideas and technical innovation.

We are looking for a post-doctoral scientist to join Dr Anne Bertolotti’s pioneering research programme, which focuses on innovative approaches to rescue cells from protein misfolding, a condition at the origin of many human diseases, including neurodegenerative diseases. One of such approaches consist in selective inhibition of phosphatases, an important discovery because phosphatases were thought to be undruggable before this work (see Tsaytler et al., 2011, Science, 332, 91-4; and Das et al., 2015, Science, 348, 239-242, Carrara, M., Sigurdardottir, A., & Bertolotti, A. (2017). Nat Struct Mol Biol, 24(9), 708–716).

You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animals models of degenerative diseases. We also have an excellent record of innovative basic research leading to applications in medicine.

You will make a significant contribution to a project aimed at capitalizing on our pioneering discoveries on phosphatases and assess the therapeutic potential of newly discovered inhibitors in diverse mouse models of neurodegenerative diseases.

You will have a PhD molecular biology or due to complete doctoral studies within 6 months of applying. Relevant experience is required and this must be best attested by at least one impactful publication. Experience working with mice and conducting behavioral and molecular studies in mice is essential. Experience with neurodegenerative diseases and having an interest in chemical biology, signaling and/or stress responses/protein quality control is desirable.

You will enjoy interacting with a dynamic interdisciplinary team sharing a passion for science and a commitment to explore the unknown.

The successful candidate will be awarded a three-year MRC Career Development Fellowship/MRC Postdoctoral Training Scheme, which is a training and development position for a postdoctoral scientist who has recently completed doctoral studies or is moving into a new research discipline.

Further information about the position may be obtained from Dr Anne Bertolotti ([email protected])

Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement and Benenden Healthcare membership. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.

The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org.

Closing date: 30 July 2018

Final appointments will be subject to a pre-employment screening.
The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme


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