Division: Cancer Therapeutics
Team: Hit Discovery & Structural Design
Type of Contract: Fixed Term
Length of Contract: 1 year
Salary Range: up to £35,538 p.a. inclusive
Work Location: London and Sutton (Surrey)
Hours per week: 35
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.
Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.
The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.
A postdoctoral position is now available in the Hit Discovery and Structural Design Team within the Unit. The team combines assay development and small-molecule high-throughput screening with fragment-based hit discovery, biophysical assays and X-ray crystallography. These methodologies are underpinned by state-of-the art protein expression, purification and protein characterisation capabilities allowing the generation of large quantities of high quality protein targets. The successful candidate will establish the successful expression, purification and characterisation of one of our early stage targets, using contemporary expression systems and purification methods available within the Team. The Post-doc will establish the in-house crystallisation and structure determination for this exciting early stage target in CTU’s drug discovery portfolio and subsequently carry out the structural determination of protein-ligand complexes. In addition, the post-holder is expected to initiate the development of biochemical and biophysical assays development to monitor protein function. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists and structural biologists and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey.
Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, & protein crystallography). Expertise in assay development and biophysical techniques would be advantageous.
The starting salary for the position will be up to £35,538p.a. inclusive (based on previous experience) and the post is offered on a fixed term contract of 1 year. Informal enquiries to
[email protected] and please click below to apply
The closing date is 17 February 2017.
