Infectious disease and inflammation are closely connected. Uncontrolled inflammation will lead to tissue damage and may become chronic as in inflammatory bowel disease. Chemical mediators such as reactive oxygen species (ROS) generated by NADPH oxidase enzymes are crucial to destroy pathogens but can also fuel inflammation. Translating new insights from animal studies into therapeutic strategies will be our next step. We are starting two new projects: one project will develop novel small molecule compounds to alleviate intestinal inflammation, and involves a collaborative effort in drug discovery and modelling, and cell-based biochemical and functional lead compound assessment (expertise in advanced cell culture methods, enzymatic activity assays, microscopy/flow cytometry, and functional studies). The other project will develop tools to alter macrophages for cancer immunotherapy (expertise in macrophage biology, in vivo studies, advanced microscopy essential). We are looking for motivated, team-oriented researchers with excellent communication and writing skills.
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