The Rosalind Franklin Institute is a national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology. As a Postdoctoral Research Associate within the Structural Biology theme of the Rosalind Franklin Institute, you will use an integrative structural cell biological approach to dissect the molecular mechanisms responsible for cytoskeletal localisation and organisation in different regions of the neuron, from cell body to synapse. You will learn core tissue culture techniques as applied to cryoET and develop skills transitioning to the analysis of tissues.
Working with collaborators at UCL and the Mary Lyon Centre, you will develop methods for targeting specific neuronal features and characterize the structural and mechanistic changes of the cytoskeleton in stem cell or tissue-derived neurons. The successful candidate will establish a workflow to culture and prepare neuronal cells for integrative imaging using fluorescence microscopy, cryoFIB/SEM, cryoET and sub-volume averaging. Your work will shed light upon the molecular organisation of the cytoskeleton in different regions of the neuron and begin to highlight how these elements change in response to disease-specific mutations or in pathologically-relevant models of neurodegeneration.
You will gain expertise (and training) in electron cryo-tomography using cutting-edge microscopes developed at the Franklin. This post would be ideal for a candidate who has worked, or is willing to drive developments, in eukaryotic and stem cell culture methods and would like to develop skills in structural cell biology and electron cryo-tomography applied to complex systems.
This post is open for 3 years in the research group of Michael Grange. Informal enquiries may be directed to
[email protected].
Responsibilities
You will:
Embrace the primary project associated with this role, involving cell culture of primary neuronal cells/tissues, stem cells for differentiation into neuronal cell lines, preparation of samples for cryoET, structure/function analysis of proteins involved in cytoskeletal organisation and the development of methods to visualize and assess the 3D organisations of these proteins in their native cellular context.
Drive your own research within the scientific scope of the project, including formulating and testing scientific hypotheses, analyzing cryoET data produced in-situ, and developing new directions for scientific exploration.
Design and carry out experiments in collaboration with other researchers within the Franklin, as well as institutions around the UK and globally.
Contribute to the general development of research and outreach activities within the Franklin organisation, and at the new Franklin hub.
Publish research findings in leading academic journals
Present research findings in UK and worldwide academic conferences.
Take a formal or informal role in the supervision of research students and other junior lab members.
Any other duties that come up in the normal running of the facility and that can be reasonably requested of the post-holder.
In return we offer:
25 days holidays + site close for Christmas (in addition to your allowance and Bank Holidays)
Hybrid working
Generous pension scheme (employer’s contribution currently up to 18%)
Training and development opportunities for staff at all levels
Bus pass discount scheme
Access to employee discount platform via Perkbox (discounts/wellbeing/Employee Assistance/counselling)
Occupational Health services
Health cash plan
Access to wellbeing resources through Thrive
Subsidised on-site canteen
Free on-site parking
Campus location in beautiful countryside with social and sports clubs open to staff
Before submitting your application please ensure you read the Job Information Pack for full details of this role by clicking on the attachment at the bottom of this page.
About us: The Rosalind Franklin Institute is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology.
Location: The Franklin is based in Harwell Campus, UK’s innovation hub and well-established as one of the leading science and innovation campuses in Europe.
At the Rosalind Franklin Institute we welcome applications from all around the world!
Closing date: Sunday 8th October 2023
