PDRA in Biomolecule Chemistry and Chemical Biology - Nucleotide Edit (10286)

    The Role

    Within the Davis group in the Next Generation Chemistry theme, one of the aims is to develop new synthetic chemical methods to edit complex biomolecules as a form of post-translational mutagenesis. Specifically, this project will develop new methods for the manipulation of complex protein [see e.g. Nature, 2020, 585, 530], sugar [see e.g. Nature, 2016, 540, 574; Nature 2018, 563, 235-240], lipid [see e.g. J. Am. Chem. Soc. 2014, 136, 566-569; Cell 2018, 175, 1045-1058] and/or nucleic acid [see e.g. Nature, 2016, 540, 574, Angew. Chem. Intl Ed. 2013, 52, 10553-10558] substrates. Within this theme, you will expand on these discoveries and develop new methods for chemical manipulation of biomolecules in ever more complex environments to probe fundamental aspects of biology and medicine. The post, reports to the Franklin’s Theme Lead for Chemistry (Ben Davis), as well as key academic collaborators and will work alongside other researchers in the Franklin and at partner university institutes including at the University of Oxford (where some groups, such as the Davis group, are jointly based).

    About you

    Candidates must hold a post-graduate qualification/PhD (or equivalent experience) in Chemistry, Biochemistry or Chemical Biology, Biology, Biomolecular Science, or related subjects. We are looking for candidates with a demonstrated aptitude for protein and/or sugar and/or lipid chemistry and/or nucleic acid chemistry and associated methods. Experience in synthetic methods applied to biomolecules and functional application as well as experience in project management are essential for this role.

    Before submitting your application please ensure you read the Job Information Pack for full details of this role.

    About us

    The Rosalind Franklin Institute is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology.

    Location: The Franklin is based in Harwell Campus, UK’s innovation hub and well-established as one of the leading science and innovation campuses in Europe.

    Closing date: Sunday 18th June 2023

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