Postdoc in lmmunology / Nucleic Acid lmmunity (m/f /d)

    The University Hospital Heidelberg (UKHD) is one of the major healthcare centers in Germany. Our objective is the development cf innovative diagnostics and therapies as weil as their quick implementation for the patient. With about 10,700 employees in more than so specialized clinical departments with almest 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

    Postdoc in lmmunology / Nucleic Acid lmmunity (m/f /d) searched for the Institute for lmmunology, Roers Lab.

    ■ Job-1D: V000010655
    ■ Field ofapplication: Institute for lmmunology
    ■ Location: Heidelberg
    ■ Start date: 01.03.2023
    ■ Job Category: Science and teaching
    ■ Working hours: full-time
    ■ Limitation: Temporary (initially limited to 3 years with the option of extension)
    ■ Ctontract: TV-L

    Job description
    We investigate pathogenetic principles in autoimmune diseases caused by aberrant activation of nucleic acid sensors. lnnate immune detection of viral infection relies an sensing of viral DNA or RNA by specialized pattern recognition receptors that trigger antiviral type I IFN and NF-kB responses. While acute activation of antiviral immunity is essential for defense, chronic activation of the same pathways can cause a breakdown of Tand B cell self-tolerance and Lead to devastating autoimmunity, as for example in Systemic Lupus and many related conditions. In the setting of Collaborative Research Center 237, we address molecular mechanisms of inappropriate activation and regulation of innate antiviral immunity using cell culture, mause models and human samples. Spontaneous activation of nucleic acid sensors by endogenous DNA or RNA is also relevant in tumor cells and is emerging as an important determinant of anti­tumor immunity.

    A successful candidate will use
    ■ genetic engineering (CRISPR, recombineering)
    ■ mause genetics, conditional gene targeting
    ■ single cell RNA sequencing
    ■ cell culture
    ■ immunohistochemistry
    ■ flow cytometry

    Your profile
    We are looking for a dedicated and enthusiastic PhD or MD experienced in CRISPR-mediated genome engineering. We appreciate experience in writing scientific publications and expect motivation to work independently and to develop a research field.

    We offer
    ■ A vibrant international research environment
    ■ A comprehensive spectrum of key technology
    ■ Collaborative work in a friendly team
    ■ Flexible working hours
    ■ Target-oriented individual further education and training opportunities
    ■ Targeted training an the job
    ■ Ticket for public transport
    ■ Subsidy for holiday care for school children
    ■ Active health promotion
    ■ Company pension scheme
    ■ Access to the university library and other university facilities (e.g. university sports)

    Contact & Application
    For any questions please contact Professor Axel Roers by phone or email.
    We are looking forward for your application by email. Applicants should submit a full CV, List of publications and a motivation letter including a description of previous research experience, a summary cf the PhD thesis, certificates and recommendation Letters or contact details of referees.

    Institut für Immunologie Prof. Axel Roers, Director
    Im Neuenheimer Feld 305 69120 Heidelberg
    phone: +49 6221 56-4001 [email protected]

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