Postdoctoral research position DNA repair in BRCA1-mutated cancers, Leiden
Are you fascinated by how DNA damage is repaired and do you want to contribute to better treatment possibilities for patients? In our lab (Van Attikum lab) we study the fundamental processes of DNA double-strand break repair in cells, and how deregulation of this process results in cancer development. With our studies we aim to contribute to better treatment possibilities for patients, focusing on BRCA1-deficient cancers with defects in DNA double-strand break repair. For an ongoing project in the lab, funded by the KWF project grant, we are looking for a postdoctoral fellow experienced in DNA repair research.
You hold a PhD in cell biology, molecular biology or a related field and you are an enthusiastic and highly motivated scientist dedicated to drive your project to success. You have proven research abilities with at least one peer-reviewed, high-impact first-author publication. You have experience in DNA cloning, cell culture, CRISPR-Cas9 based genome-editing, microscopy, chromatin immunoprecipitation and next-generation sequencing. Bioinformatics skills for the analysis of next-generation sequencing data are a prerequisite. Furthermore, you like to work in a dynamic, multi-disciplinary and diverse team and take responsibility for your own project.
What we offer
You will be employed on the basis of a 36- hour week. Appointment is for 1 year, possibly to be extended with another year. Your salary will depend on your qualifications and experience, with a maximum of €4.800,- gross per month based on a 36-hour week (scale 10, CAO UMC).
Working at the LUMC
The LUMC, situated in Leiden, the Netherlands, is an academic medical centre for patient care, research and education, aiming to meet the challenges of tomorrow’s health care. It has a strong focus on research, connecting and combining fundamental research into disease-causing mechanisms with patient-focussed studies in areas like oncology, regenerative medicine and population health. The LUMC has research facilities that include capabilities for multiple appliances. The combination with clinical and societal outreach programmes allows for ground-breaking research and innovation in basic and applied science.
The Department of Human Genetics is a broadly oriented research department, focusing on the (epi)genomic contribution to diseases. The department consists of 23 research units, embedded in four overarching research lines. You will work in the research group which is embedded in the research line ‘Genome instability and cancer’ and has a clear focus on better understanding the fundamental mechanisms of DNA damage repair to improve clinical management of cancer patients. More specifically, research in the Van Attikum lab aims at identifying and characterizing enzymes that operate during DNA repair processes in human cells using a cross-disciplinary approach that combines novel and cutting-edge genomics approaches with bioinformatics, genetics, biochemistry and high-resolution microscopy.
A detailed job description can be found at www.lumc.nl/vacancies
. You may also contact Prof. Dr. Haico van Attikum, Professor, Human Genetics department, phone +31 (0) 71 526 96 24.
More information on the Van Attikum group can be found at Chromatin and DNA repair | LUMC
How to apply
Please send your email, including your motivation, CV and the names and contact information of two references to [email protected]
Make sure to do this before 03-10-2022. Clearly state the vacancy number of the position you are applying for.
It is also possible to apply via our online form at lumc.nl/vacancies.