Postdoctoral Training Fellow: High-throughput X-ray crystallography

Closing Date of vacancy: 6 Aug 2015
Division: Cancer Therapeutics
Team: Hit Discovery & Structural Design
Type of Contract: Fixed Term
Length of Contract: 1 year in the first instance
Salary Range: £33,110 to £36,858
Work Location: London and Sutton (Surrey)
Hours per week: 35

The Cancer Research UK Cancer Therapeutics Unit, within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s exciting goal is to discover high quality drug candidates for validated biological targets and to progress these candidates to clinical trial. All the scientific disciplines are in place to make this possible. Our biologists work alongside world-class chemists and drug metabolism specialists focusing on new molecular targets emerging from human genome and ground breaking cell biology research. This is an exciting and fast moving area of cancer research, and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment.

A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CTU. The Post-doc will be involved in high-throughput X-ray crystallography, fragment-based screening and structure-based drug design and will be responsible for crystallisation, structure determination and structural analysis of protein-ligand complexes from one or more of the CTU’s drug discovery programmes. The successful candidate will also be part of the Division of Structural Biology, in which the crystallographers in Dr van Montfort’s team are embedded, and will have access to state of the art crystallisation facilities, in-house X-ray sources and excellent access to synchrotrons. The successful candidate will interact closely with the biology, computational chemistry and medicinal chemistry teams at the CTU, and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey.

Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, and protein crystallography). Experience in molecular biology, structure-based drug design, and/or biophysics will be an advantage.

Appointment will be to a Postdoctoral Training Fellowship with starting salary in the range of £33,110 to £36,858 p.a. inclusive (based on previous experience). Appointment will be for 1 year in the first instance, and benefits from a contributory defined benefit pension scheme and generous leave entitlement. Further information can be found in the full job description at www.icr.ac.uk

Informal enquiries to [email protected] or [email protected]. Please DO NOT send your application to Dr van Montfort or Dr Westwood; CVs must be submitted via the ICR website.