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5474| King Abdullah University of Science and Technology| Post-Doctoral Fellow in Benthic Ecology| KAUST (King Abdullah University of Science and Technology)

Post-Doctoral Fellow in Benthic Ecology
Competitive Tax-free Salary

The Saudi Aramco Environmental Research Center at KAUST (SAMERCK) is seeking a post-doctoral researcher in the area of benthic ecology. Much of our work at SAMERCK is driven by the need to quantify and forecast responses to environmental change. As part of the ecological component of this new Center, overall studies aim to understand the major processes driving the structure and function of coastal systems, in particular how natural and human disturbances influence the biodiversity patterns and biological production.  

We seek applicants to participate in ongoing research about the direct and indirect effects of multiple pressures on diversity and functioning of coastal benthic communities along the Saudi Arabian Red Sea coast. The successful candidate should have expertise in areas such as: (1) the link between biodiversity and ecosystem functioning; (2) the relationships between environmental parameters and variability in soft-sediment assemblages (diversity and structure); (3) the use of multiple ecological indicators to assess environmental quality of benthic habitats; (4) statistical analysis and interpretation of community data (biodiversity, structure and trophic relationships), and/or predictive modelling tools to better understand the distribution of species/assemblages. Collaborations amongst SAMERCK research fields (oceanography, GIS spatial analysis) will be strongly supported.

Qualifications/Competencies
• PhD in Marine (Benthic) Ecology (or other related field) and preferably postdoc experience(s);
• Proven publication record in the field of marine benthic ecology with solid knowledge in macrobenthic species taxonomy;
• Documented experience of extensive ecological field surveys;
• Competency in applying and interpreting statistical analyses;
• Fluent in English, both spoken and written;
• Excellent written and verbal communication skills;
• Ability to work in multidisciplinary teams;
• Ability to produce high quality deliverables on time and to work in a multi-tasking environment;
• Good organizational skills and a strong ability to accomplish tasks independently.
• The successful candidate should be able to identify the most accurate indicators for the assessment of the ecological state of Red Sea benthic habitats, as well as to propose the thresholds to be used in future monitoring.

Main tasks:
• Conduct laboratory and field work;
• Collect and process biological and environmental samples;
• Manage the laboratory facilities (order supplies and maintain equipment);
• Conduct data analysis and contribute to the writing of reports, manuscripts and projects;
• Test several biotic indices and assess their effectiveness on the assessment of the ecological status of Saudi Arabian Red Sea.
• Identify/develop accurate indicators for the assessment of the ecological state of Red Sea benthic habitats, as well as propose the thresholds for future monitoring.

The position is for three years (renewal each year depending on performance) and includes a competitive tax-free salary and other benefits (housing, health and life insurances, etc.).

To apply, please submit a single pdf file with a cover letter, including a statement of research interests, detailed curriculum vitae, and the contacts of three references to Susana.carvalho@kaust.edu.sa






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5478| University of Lincoln, College of Science - School of Computer Science| Research Fellow: to develop advanced techniques for aggregating and interpreting Lifelogging data from heterogeneous sensors for ophthalmic care| Research Fellow

College of Science - School of Computer Science

Salary £30,728+ with generous benefits

Post reference: COS067

The University of Lincoln is seeking to appoint a Research Fellow to join the Laboratory of Vision Engineering, at the School of Computer Science, which is an internationally recognised centre for its research in capture, transmission, processing and understanding of (medical) image, video and other high-dimensional data. The centre has developed numerous techniques in machine learning, (medical) image analysis and computer vision.

The post is fixed-term for 18 months funded by EPSRC and provides a unique opportunity to join the team and contribute/participate in the project that aims to develop advanced techniques for aggregating and interpreting Lifelogging data from heterogeneous sensors for ophthalmic care. The system will feature new techniques enabling simultaneously and long-term quantifying the functional impairment related to vision underpinned with smart glasses (e.g. Google-Glass). The findings will be utilized as a platform to assess the impact of visual impairment on the quality of life (QoL) of ophthalmic patients both in general health terms and in vision specific terms. The research will be conducted through direct exposure to the clinical collaborator, Moorfields Eye Hospital.

The successful candidate will focus on investigating novel data mining and machine learning techniques for the analysis and integration of Lifelogging data from heterogeneous sensors to allow for the assessment of QoL. You will be responsible for:

1. Developing a new probabilistic machine learning model for classification of the associated Lifelogging data (i.e. multivariate time series)
2. Developing strategies to integrate data from heterogeneous sensors into decision support models. You will be expected to contribute both of theoretical work and software development and you will also be expected to prepare research reports, papers and presentations.

Candidates are expected to hold a PhD degree (or have submitted a PhD thesis) in computer science or in a related discipline. Experience in one or more of the following topics is expected: data mining / classification, machine learning, feature extraction, statistics and regression. Knowledge of cloud computing, and web server development is desirable.

The University of Lincoln is a forward-thinking, ambitious institution and you will be working in the heart of a thriving, beautiful, safe and friendly city.
If you would like to be part of shaping our world-class vision to make a real difference and would like to know more about this opportunity, please contact Dr Xujiong Ye (Reader via telephone 01522 83 7344 or via email xye@lincoln.ac.uk).

For further information or to apply online please visit our website at http://jobs.lincoln.ac.uk/

If you have any queries please email jobs@lincoln.ac.uk or telephone 01522 886 775. Please quote the job reference number and title in all correspondence.

Closing date: 13th May

As a member of the Athena SWAN Charter we are committed to advancing gender equality in STEM, therefore female applicants are strongly encouraged to apply.
1004948| Blue Marble Recruitment| Post-Doc Organic Electronics Materials Researcher - Cambs|

My clients in Cambridgeshire are looking for a Post-Doc Organic Electronics Materials Researcher. The role is on a temporary 2 year fixed term basis.

This role is commutable from Cambridge, Bedford, St. Neots, Huntingdon, Sandy, Yaxley.

JOB PURPOSE:
Pursue materials research with the aim to:
(1) gain a deeper understanding of the structural features required for realising solvent-orthogonal functional materials for the solution processing of multi-layered organic electronic devices.
(2) identify novel structural features that result in improved solvent-orthogonality.
(3) investigate the impact of the presence of these structural features in electronically functional materials on device performance and lifetime.
Working closely with the synthetic chemists and device scientists in the team, the purpose of the role includes the development of Interlayer materials that show negligible swelling and intermixing upon deposition of the successive layers during the solution-processing of devices.

KEY RESULT AREAS:
Creation of a detailed understanding of the factors that determine the solubility and phase behaviour (miscibility) of electronically functional organic materials and blends thereof.
Realisation of electronically functional materials that show improved solution-processability, including solvent-orthogonality to prevent intermixing and diffusion at interfaces.
Contribution to expanding the company's Intellectual Property (IP) portfolio.

MAIN ACTIVITIES:
Development of novel strategies with the aim to realise combinations of electronically functional materials that show near-complete solvent-orthogonality in multilayer stacks.
Synthesis of solvent-orthogonal functional materials, with support from the chemistry team.
Using a wide range of characterisation techniques accessible in-house and via collaborations with third parties, characterisation of solvent-orthogonal materials in solution, in bulk, and as multi-layer stacks (including interfaces between adjacent layers). The characterisation techniques to be used will include non-standard techniques such as impedance spectroscopy, Atomic Force Microscopy (AFM) including conductive and Kelvin probe AFM, Photoelectron Spectroscopy (XPS and UPS), Scanning Electron Microscopy (SEM), Micro-Raman, and additional, non-standard techniques.
Testing of novel solvent-orthogonal materials in devices, including device fabrication in company Cleanroom facilities and characterisation of these devices in collaboration with the device scientists.
Liaise with other technical teams within the company to maintain awareness of developments that require the production of functional materials with improved solution properties, and contribute as appropriate.

KEY WORKING RELATIONSHIPS:
Work closely with the members of the chemistry group within the team, and with the analysts, the Chemistry Basics, and the Device Basics teams.
Work closely with the Device Scientist and the Team Leader.

KNOWLEDGE/EXPERIENCE/SKILLS REQUIRED:
PhD-degree in Polymer Physics, Materials Science or Chemistry.
First-class academic credentials and excellent knowledge in the fields of Polymer Physics, Thermodynamics, and Organic Chemistry.
Creativity, inventiveness, and an aptitude for experimental work.
Self-motivation and ability to operateindependently in a laboratory environment.
Strong team-playing skills and excellent interpersonal skills, with the ability to operate in multi-disciplinary and cross-functional teams.
An understanding of the particular demands of target-driven industrial research, and ability and willingness to work towards critical deadlines.

1004950| Next Ventures Ltd| Data Science Director- New Team within Top Tier Bank LONDON £100,000-£|

Data Science Director- New Team within Top Tier Bank LONDON £100,000-£135,000 & package

Keywords: Data Science, Hadoop, Data Analytics, Director, Management, Insight

My client, a global banking group based in London are currently looking to hire a Data Science Director to lead a brand new team of PhD qualified Data Scientists.

The purpose of the team is to create actionable insight into corporate client behaviour, analysing and interpreting large and highly disjointed datasets in such a manner that insight and behaviours can be extracted and readily explained to a diverse group of stakeholders.

The Data Science Director will:

  • Identify, source and warehouse potentially insightful data, such as historic client trading activity from across and above businesses.
  • You will use appropriate statistical techniques, data engineering, event processing, machine learning and data visualisation to present results that can be easily understood by management, product specialists, salespersons, relationship managers and clients.  
  • You will understand the business, business drivers and client needs whilst gathering a ful understanding of how the business systems operate.
  • Your most important task will also be to grow and develop the team from scratch. You will use agencies and your own contacts to recruit a team of 6-8, initially. Therefore demonstrable experience of this level of management is required.

The ideal Data Science Director will have the following skills:

  • A degree (PhD is preferable) in disciplines such as (but not limited to) systems biology, genetics, bioinformatics, climatology, urban planning, computer science or engineering.
  • Ideally 5+ years' experience in advanced data analytics and data science within an organisation where focus on margins is key. Evidence of growing a team and management experience is also expected where you are capable of giving details of examples.
  • Experience extracting valuable information from diverse datasets.
  • Experience using R, SPSS, Stats, Matlab, Mathematica, Hadoop, Mapreduce, Python and Perl.

A rare opportunity to join a market leader and develop a team from scratch, enabling the team to thrive in an autonomous fashion whilst maintaining the backing and support of the business.

 For more information, apply now with a detailed CV.

Data Science Director- New Team within Top Tier Bank LONDON £100,000-£135,000 & package

1004829| Applitracker| Brand Manager-new challenge -Italy| Are you a product specialist looking for a future step in your career? In the same time you are eager to add value to your scientific background by joining a global company? Then this opportunity is the answer to all your questions as my client a reputed pharmaceutical company that is seeking a Product Manger with strong scientific background and great sales skills

This is an amazing opportunity which will give you the chance to build and develop relationships with medical institutions all over Italy. Diversity will be the core work of this role, as you will combine your passion for science with your strong sales skills and you will provide the medical institutions with a new innovative product.

The successful candidate for this role will have:

* Previous experience in a pharmaceutical company as product specialist/brand manager/product manager
* Extensive experience in Sales within a pharmaceutical company
* PhD or Life Science Degree
* Good knowledge of English
* Strong scientific background , ideally within neurology

My client offers a competitive compensation package commensurate with your background and experience plus extra benefits.

To apply please send a Word copy for your CV at . Alternatively if you would like to know more about this role or other opportunities in this field don't hesitate to contact Inca Busoi at (0) .
1004833| Applitracker| Head of Operations - Clinical development - Paris| My client, a global pharmaceutical company are currently hiring for a head of operations for their office in France. Applications from candidates with strong managerial skills and experience in a clinical trial setting are invited to apply.







Applicants should ideally have either a MD or a PhD degree and good knowledge of clinical development and the regulations which apply to it. You must also have excellent managerial skills as this task will involve managing many clinical trials with large amounts of direct reports. None of these criteria are absolutely mandatory and therefore, if you believe that you have the relevant skills to add value to this company as a director of operations, please don't hesitate to apply now.







If this role is of interest to you then do not hesitate to apply today as my client is looking to start interviewing immediately. Please apply by sending your CV in MS Word format to me directly, Sebastian Pal, at , or by calling me on for a discussion in confidence.
5492| FindAUniversity| Test| Test
5485| AstraZeneca| US Postdoctoral Opportunity Pharmacology- pharmacokinetics (PBPK) modeling| Comparison of physiologically based pharmacokinetics (PBPK) modeling and allometric scaling approach to guide pediatric clinical trial design

At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca's commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines.

Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists.

Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.

Candidate Focus and Challenge

Major responsibilities:

• Perform literature searches and evaluate available clinical pediatric reports
• Collection of both preclinical and clinical adult and pediatric data for identified drugs
• Develop PBPK models and population allometric scaling models with the collected data
• Develop an approach to compare pros and cons of both methodology and propose good practice based on findings
• Validate proposed good practices with emerging data
• Develop skills in both clinical pharmacology and pharmacometrics and its impact in drug development process especially toward pediatric development
• Willing to develop and freely share new idea to improve or enhance current process
• Actively engaged with all the AZ and academic supervisors
• Collaborate with other scientist within Astrazenca global while able to work solitarily
• Publish scientific papers describing findings from the project and especially any novel method/approaches
• Key deliverables:
• Delivery of modelling and data analysis methods for the collected data and proposed good practice/recommendation

Candidate Knowledge, Skills and Experience

Minimum Requirements:

• A PhD in pharmacokinetics, drug metabolism, pharmacology, mathematics, biomedical engineering or relevant discipline:
• Preferred experience
• Pharmacokinetic modelling physiologically based pharmacokinetic (PBPK) modelling or systems biology modelling.
• Mathematical or statistical modelling with experience in modelling biological data.
• Application of specialist in tools such as SIMCYP, Phoenix, WinNonlin, Matlab, NONMEM, R,
• Understanding of DMPK and pharmacology/safety, drug delivery, pharmacokinetic, pharmacodynamic and pediatric aspects of drug discovery and development
• Skills and Capabilities:
• Good team working and networking skills.
• Able to demonstrate the drive and energy to deliver projects.
• Demonstrate a high degree of personal credibility.
• Work collaboratively within a team and networking
• Ability to share knowledge and interpret findings
• Strong interpersonal, organizational and communication skills
• A strong scientific track record, as evidenced by published or accepted papers in peer-reviewed journals, oral and/or poster presentations at scientific meetings
• Strong commitment to science and ability to work well within a group environment
• Good communication skill as the position will require working with colleague in cross-geographic locations.
• Collaborative and interactive personality

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colo
5458| Medical Research Council, National Institute for Medical Research| Postdoctoral Scientist (IRC137353)| Division of Molecular Structure
Structural biology of protein ubiquitination

Situated in Mill Hill, North West London, NIMR is the largest MRC institute, supporting some 70 research groups and 500 bench scientists. The Institute provides excellent training for researchers in a multi-disciplinary environment and is equipped with state of the art facilities.
http://www.nimr.mrc.ac.uk/employment/

Applications are invited for a Postdoctoral position in the Division of Molecular Structure in the group of Katrin Rittinger. The position is aimed at the structural and mechanistic characterisation of proteins that are part of the ubiquitin transfer cascade, with a focus on E3 ubiquitin ligases. In particular, we are interested in determining how different types of poly-ubiquitin chains are synthesized and how their linkage type determines specificity in signalling.

The successful candidate will have a PhD (or be in the final stages of completion) in biochemistry, biophysics or structural biology. Knowledge of basic molecular biology techniques and protein expression is essential. Previous experience in X-ray crystallography, enzyme kinetics and the use of biophysical techniques for the characterisation of protein complexes would be an advantage.
Applicants should be able to learn quickly, have an interest in collaborative work, be able to communicate scientific ideas effectively and have a proven publication record.

For more information on this position please contact Dr. Katrin Rittinger via e-mail katrin.rittinger@nimr.mrc.ac.uk.

In return for your talents, we offer a competitive salary, 30 days annual leave on appointment, a final salary pension scheme and flexible working hours.

Applications are handled by the UK Shared Business Services; candidates with a solid track record of academic achievements are encouraged to apply. Please visit our job board at http://www.topcareer.jobs/Vacancy/irc137353_4312.aspx and upload your CV along with a letter of motivation, (when saving your documents quote reference IRC137353 in the filename.)

Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867000 and quote the reference number.

Closing date: 29th April 2014

The MRC is an Equal Opportunities Employer
Final appointments will be subject to a pre employment screening
1004867| University Of Illinois| Visiting Coordinator-Center for Advamced Researc in Drying| Visiting Coordinator for the Center for
Advanced Research in Drying (CARD)

Department of Food Science and Human Nutrition
College of Agricultural, Consumer,
and Environmental Sciences
University of Illinois at Urbana-Champaign

The Department of Food Science and Human Nutrition at the University of Illinois at Urbana-Champaign is seeking applicants for a full-time (100% FTE) Visiting Coordinator. The Visiting Coordinator will lead and manage program coordination and provide day-to-day support to the Director for the Center for Advanced Research in Drying (CARD), a federally and industry funded grant. Specific duties and responsibilities include:

-^Initiate, coordinate and manage CARD resources, including budgets, grants, partners and performance risks by collecting and analyzing relevant data
-^Facilitate meetings for internal and external partners and oversee and co-direct site visits by federal and industry sponsors
-^Develop and disseminate communication and marketing materials
-^Lead logistical planning related to vision, mission and goals of the program to enable advancement of research and outreach activities for long-term sustainability
-^Integrate financial and technical data and other relevant factors into technical and status reports

Minimum Qualifications: Candidates must have a Bachelor's degree from an accredited institution of higher education and at least three (3) years of experience in coordination of research program projects or oversight of program project progress or a Master's degree; ability to work in a collaborative, team-oriented environment; enthusiasm, self-motivation and in dependence in a work environment; and excellent written and oral communication, inter-personal and organizational skills.

Preferred Qualifications: The ideal candidate will hold a relevant degree (MS or PhD in food sciences, engineering, agricultural sciences or related field) and have experience working in an academic or industrial research environment; experience with communications and/or business development and grants, reports and press releases; ability to work with campus administration, faculty, support staff and students; excellent computer skills, including competency in computer graphics, MS Office applications, and website development; and ability to understand food, food science, engineering and technology applications.

The Visiting Coordinator is a 100% FTE, benefits-eligible Academic Professional position. This position will end on or before 2 years from the date of hire. Salary is commensurate with skills and experience, and candidates must have valid legal authorization to work in the United States by the starting date of the position. For full consideration, applications must be received on or before April 23, 2014. Applicants may be interviewed prior to the closing date; however, no hiring decision will be made until after that date. The expected start date is as soon as possible after the closing date. Please create your candidate profile at
go.illinois.edu/VstCoordCARD
and upload your cover letter, resume or CV, and the names, addresses, e-mail addresses, and phone numbers for three (3) professional references on or before April 23, 2014. All requested information must be entered for your application to be considered. For further information, please contact Betsy Lancaster, Search Coordinator/Diversity Advocate
( ).

The reporting line for this position is: Dean, College of Agricultural, Consumer, and Environmental Sciences; Department Head, Food Science and Human Nutrition; Director, Center for Advanced Research in Drying; Visiting Coordinator for the Center for Advanced Research in Drying.

Illinois is an Affirmative Action/Equal Opportunity
Employer and welcomes individuals with diverse
backgrounds, experiences, and ideas who embrace
and value diversity and inclusivity.
()
5480| AstraZeneca| US Postdoctoral Opportunity Oncology iMed- Cell uptake and target inhibition| Building fundamental mechanistic insights into productive cell uptake of short single strand oligonucleotides (ASOs)

At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca's commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines.

Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists.
Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.

The aim of this project is to explore the contribution of specific tumour microenvironment factors to the productive uptake of antisense oligonucleotides (ASOs) into tumor cells, leading to effective target knockdown. The focus will be on diffuse large B-cell lymphoma (DLBCL), and gaining insight into two potential mechanisms that can drive the productive uptake and intracellular trafficking of ASOs: extracellular matrix interactions and macrophage-mediated exosomal delivery.

Successful execution of the project requires:

Skill and expertise (some from graduate work, some to be gained during the postdoctoral research project) in the areas of:

• Extracellular matrix regulation of intracellular trafficking
• State-of-the-art intracellular imaging techniques
• Macrophage function / exosome biology
• Working collaboratively with internal and external experts in these areas.
• Synthesis of findings in these areas to gain novel insights into mechanisms that control ASO uptake and trafficking, leading to target knockdown in tumor cells
• Deliverables by the end of the project include:
• Novel findings that enhance the understanding of the mechanisms that drive cellular uptake and intracellular trafficking of ASOs
• Identification of the roles of specific proteins in tumor cells that could be expoited to improve uptake of ASOs, leading to improved target knockdown and activity
• Share progress with AstraZeneca collaborators in oligonucleotide therapeutic programs, including Isis and Regulus
• Minimum of one publication in a top tier, peer reviewed journal
• Presentation of findings at a major cancer, cell biology, or oligonucleotide focused international meeting
• The results of this research have the potential to lead to therapeutic approaches that enhance productive uptake of ASOs, including the potential to direct the chemistry and design of oligonucleotides to maximize productive uptake for existing programs, and to enable selection of patients most likely to respond to ASO therapy


Candidate Knowledge, Skills and Experience

Minimum experience and expertise:

• Recent PhD, with research focused in the areas of extracellular matrix interactions, intracellular trafficking, and/or macrophage biology in oncology
• Papers in one or more of the above areas published or accepted in peer-reviewed journals
• Expertise in cell biology techniques
• Ability to develop and test hypotheses based on observations from multiple disciplines
• Additional desired (but not required) experience:
• Expertise with intracellular imaging techniques
• Experience w
5508| Royal Veterinary College, University of London| Postdoctoral Research Associate| Postdoctoral Research Associate
Camden, North London
c. £31.1k inclusive of London Allowance

This is a fixed term contract for 18 months.

Job summary:
A postdoctoral research associate with expertise and interest in mitochondrial cell biology and pharmacology is needed to study the functional role of the mitochondrial Translocator Protein (TSPO) in the context of brain cells signalling and quality control. This is part of on-going collaborative work with Prof. Federico Turkheimer, Department of Neuroimaging, Institute of Psychiatry, King's College London and will see a large use of live cells imaging methodologies complemented by standard techniques of biochemistry and molecular biology. The team leader will guarantee training in the experimental hallmarks of the laboratory.

The successful applicant will join a team of competent researchers and work in state of the art laboratories benefiting of generous access to instrumentations of the highest quality and assisted by professional technical support. The research team contributes a larger unit focused on the Cell Biology and Pharmacology of Diseases composed PostDocs, PhD students and Research Assistants who will guarantee the critical mass to exchange ideas, overcome pitfalls of the experimental routine and refine protocols. Nonetheless, the team is also part of the UCL Consortium for Mitochondrial Research (CfMR): an ideal setting to discuss findings, gain advices and guidance on matters relevant for the project. All this renders the offered position the perfect opportunity for a qualified PhD who wants to contribute to the field, rise in scientific profile via cutting edge discoveries and be part of an ambitious long-term research programme.

Main duties and responsibilities
The post is full time and the successful applicant will be responsible to run the experimental program outlined in the awarded grant, analyse data and prepare these for the circulation in high-impacted research journal. He/She will also assist with the supervision of Postgraduate and Undergraduate students, attend and present regularly at the weekly laboratory meeting besides assist in the PI in ensuring smooth and ordered unfolding of the experimental routine of the research group. The research focus for this project is the identification of the TSPO role in mitochondrial function, cellular signalling, and processes devoted to the preservation of cellular quality in neuronal cells. This will be exploited by addressing mitochondrial autophagy, Ca2+ signalling, ATP homeostasis, Reactive Oxygen Species generation to be assessed by cutting edge techniques of luminescence and imaging complemented with experiments of Western Blotting, Immunohistochemistry, Knock-in Konck-out techniques.

Your profile
Applicants must hold a PhD in a relevant field of research such Biochemistry, Cell Biology, or Molecular Biology and prevalently possess knowledge in at least one of the following methods: tissue culturing, live cells imaging, Ca2+ signalling, genes transduction, autophagy signalling, cell death assays, immunoblotting, proteins profiling and molecular biology. A can do attitude will be determinant to cover the various tasks requested in the job as well as motivation will be key to succeed.
To apply applicants must make their formal application online through the RVC website. Please complete the online application form and attach your CV, potential referees, links to recent publications, and a copy of your Ph.D. thesis. Prospective applicants are encouraged to contact Dr. Michelangelo Campanella (mcampanella@rvc.ac.uk) for further questions about this post.

The tentative start date for this role is June 2014.

We offer a generous reward package including a pension scheme.

For further information and to apply on-line please visit our website: www.rvc.ac.uk
Job Ref CBS/0046/14

Closing date: 17 May 2014
In
5477| The University of Sheffield, Materials Science and Engineering| Research Associate in Sustainable Functional Materials Technology (3 posts)| 3 positions are available for post doctoral research assistants in sustainable functional technology within the areas of magnetic, dielectric, piezoelectric, ferroelectric and thermoelectric materials and devices. The positions are part of a new EPSRC funded initiative on ‘Substitution and Sustainability in Functional Materials and Devices’. The aim of the positions is to link strongly with industry to research into the manufacture of functional devices using cost effective sustainable materials and processes.

The PDRAs are expected to work as part of a coordinated team. The PDRAs will periodically report to the management committee led by the PI Professor Ian M. Reaney but will collaborate on a day to day basis with their direct supervisor. Successful candidates should have experience in processing and fabrication of functional materials and devices and have a strong knowledge of structure property relations.

The successful candidates should have or be about to complete a PhD in functional materials and devices or a related discipline with a background in either magnetic materials or functional oxides. They are expected to prepare data, write reports and papers and present their research at major international conferences. Successful candidates will have complimentary expertise with similar skillsets to cover materials processing, materials characterisation and fabrication of devices.

The successful candidate will be working in a world leading research group in functional materials and device.

The positions are fixed term initially for two years. The posts are in the first part of a five year grant for research funded by the EPSRC in to “Substitution and Sustainability in Functional Materials and Devices”.

For full details and application enter ref UOS008356 using the web link - select "Apply Online today"
1004937| Kite Consulting Group Limited| Director, Quantitative Risk - Financial Services - London - Up to £120|

A market leading Financial Services institution is looking for a Director, Quantitative Risk to lead the development of Risk/Pricing Models that evaluate counterparty exposures to the Clearing House.

These include models related to Pricing, Value-at-Risk, Stress Testing, Liquidity, Regulatory Capital, and also developing tools for Portfolio Analytics (Sensitivities, Risk Reports, Margin Coverage, etc.).

The role also involves the development of strategies to perform back-testing of risk methodologies to ensure adequacy of different models and assumptions, and presentation to key stakeholders.

Requirements:

  • Demonstrable experience within Financial Risk Management and/or Trading, specifically within OTC (IRS, FX, and CDS) or Commodities/Futures asset classes.
  • Subject Matter Expertise level experience in advanced pricing models (options) and numerical methods, such as, Monte Carlo, Volatility Forecasting, PDEs, etc.
  • Significant interaction with the Clearing Technology Department to lead the process of implementing, testing and maintaining these risk models.
  • Ability of the staff to understand core business principles related to Dodd-Frank and other regulatory requirements as they relate to Clearinghouse Risk Management policies.  

Qualifications & Skillset:

  • MBA/MSc or PhD in Finance, Economics, or a quantitative field
  • Excellent quantitative, analytical and problem solving skills
  • Significant experience in pricing complex derivatives and performing advanced statistical analysis on underlying risk factors (returns' distribution, volatility, correlations, etc.)
    Significant experience with developing Risk Management models (eg Historical VaR, Monte Carlo, Multi-Factor, SPAN, etc.)
  • Strong knowledge or experience in Fixed Income would be preferable (FX, Rate; vanilla, exotic and hybrid) and in probability theory, stochastic processes, and PDE's.
  • Programming languages such as C++/C#, Matlab, VBA and SQL are essential.
  • Ability to work in a team environment and lead/manage mid-level and junior quants.
1004836| Applitracker| Clinical Trial Biostatistician- Lausanne/ Geneva| We are currently looking for an experienced clinical development biostatistician on behalf of a large biometrics team in French-speaking Switzerland. The role will let you develop your biostatistics skills by working in all phases of clinical trials, communcating statistical resutls to stakeholders, and representing the function at cross-functional scientific meetings. This is a role with a friendly, international team with multiple opporutnities for further training and development.

The requirements for the role include MS or PhD in Statistics and at least 4 years of experience in clinical development in the industry (in pharma, CRO, food or nutrition, or other research organization). Fluent English.

Please contact Ivelina Georgieva from NonStop Pharma Recruitment for more information via 0044 (0) or
1004891| Allergan| Principal Scientist - PKDD, in vitro model| Allergan is seeking a motivated and technically skilled scientist with strong in vitro experimental model development expertise in dermal and/or ocular scientific areas. This incumbent will lead a group to conceive, design and develop innovative in vitro experimental models to support pharmacokinetics and drug distribution activities such as dermal and ocular penetration and formulation screening for discovery programs and development projects. Primary responsibilities include in vitro model development, design and execution of in vitro experiments, sample bioanalysis, data interpretation and presentation. Candidate will be able to work independently and collaboratively with colleagues across multiple disciplines. In addition, the successful candidate will represent PKDD department to participate in discovery and development teams.

Maintain current knowledge of in vitro experimental models in ocular and dermal therapeutic areas through literature review, interaction within scientific associations and scientific meetings and professional publications.

Identify issues and provide scientifically-valid solutions to support drug discovery and development. Analyze study results, interpret data, contribute to discussions, and communicate significant events and issues to departmental and project teams. May involve preparation of quality reports and protocols for submission to regulatory and corporate agencies.



PhD +6 years or MS years or BS years specific experience with educational background in Biochemistry, Pharmaceutical Sciences
Experience for mentoring developing scientists and technical staff and working in a fast-paced team environment


Essential Skills and Abilities:

Require strong scientific skills in in vitro experimental model development in ocular and dermal areas. Creative problem-solving skill and a can-do approach.
Excellent interpersonal skills. Effective written and verbal communication skills;
Ability to multi-task and focus on priorities. Ability to find out project team requirements and report work progress to supervisor, project team members and internal departments.
Good computer skills and ability to apply Word, Excel, PowerPoint and LIMS to facilitate data analysis, data management and reporting.
1004939| Google Inc.| Software Engineer|

Software Engineer, Mountain View, CA:  Design, develop, modify, and/or test software needed for various Google projects; act as a tech lead for small projects; coordinate releases with teams dispersed across function and geography; and track dependencies between various components and features and partner with key-stakeholders to ensure smooth updates and/or releases. MS or foreign eq. in CS or rel. field w/3 years exp. OR PhD or foreign eq. in CS or rel. field w/1 year of exp. Exp. Incl: dev. software using Java and/or C++; dev, test, & enhance product and/or syst. utilities; & design, implement, test, & maintain subsystems. Employer will accept any suitable combination of education, training, or experience. Salary: $116,605/year. Sched: M-F, 9am-6pm. Send resumes to: Recruitment and Employment Office, Google Inc. Attn: Job Ref #GOO93502, P.O. Box 56625, Atlanta, GA 30343.

1004855| Capita Resourcing IT| Computational Physicist / Mathematical Modeller - £40k - £70k| Computational Physicist / Mathematical Modeller - Oxford - £40k - £70k - Oil&Gas / Modelling / Simulation / Multiphase Fluid Flow / C++

My client is a leading scientific organisation based in Oxford that specializes in developing complex modelling&simulation products that are used within the oil&gas industry. Due to continual business success they now require a number of Computational Physicists / Mathematical Modellers to analyze the underlying physics and develop numerical models to simulate underground fluid flow, build the code in C++ and support end users in running the final commercial program.

As a Computational Physicist / Mathematical Modeller you will be required to have very strong physics or maths skills and also come from a strong academic background with a BSc, MSc or PhD in a related discipline.

Key skills:

* Strong physics or maths skills ideally at PhD level
* Programming skills with languages such as - C / C++, Java, Python

Although not essential any of the following experience would be highly beneficial:

* Modelling multi phase fluid flow in porous media or pipes
* Thermodynamics and phase behaviour of complex fluids
* Working on large or commercial numerical codes
Software development lifecycle and testing

This is an opportunity to work for a technology driven company that strives to be at the forefront of technological development. They are offering a very competitive salary and a great benefits package. Please apply with your CV in MS Word format or call Jason Fashanu on for further information

Computational Physicist / Mathematical Modeller - Oxford - £40k - £70k - Oil&Gas / Modelling / Simulation / Multiphase Fluid Flow / C++

Capita Resourcing welcome applications from all suitably qualified people regardless of gender, race, disability, age or sexual orientation.

Capita Resourcing is a trading name of Capita Resourcing Ltd. Services offered are those of an Employment Agency and Employment Business. Applicants will be required to register with us.
5499| Dublin City University, National Centre for Sensor Research| Postdoctoral Researcher / Research Fellow: Development of integrated lab-on-a-chip systems implementing DNA-based methods for on-site detection of food pathogens| The Microfluidic Platforms group led by Professor Jens Ducrée is currently seeking ambitious, highly motivated researchers to advance the next generation of highly integrated and automated lab-on-a-chip technologies for fast on-site monitoring of pathogens in food samples. These breakthrough systems will be based on the interplay of a set of materials, components, and processes to enable multi-force liquid handling and detection.

Requirements: A proven background in the design of integrated lab-on-a-chip systems for applications in the life sciences is desired. Expertise in (centrifugal) microfluidics as well as other fields such as (polymer) micromachining, instrumentation and bacteria detection will be useful. The successful candidate will be a productive researcher with a proactive attitude, excellent presentation, communication and publication skills, and the proven ability to interact with a highly interdisciplinary team and our tightly linked European project partners.

Location: This position will be based in the new laboratory facilities of the Dublin City University (DCU). The DucreeLabs comprise of a very well equipped microfluidics lab, a polymer microfabrication suite and a range of specialist support units on the pleasant campus of Ireland’s University of Enterprise. Dublin is embedded in the beautiful landscapes of the green “Emerald” island on the breath taking shores of the Irish sea.
5489| AstraZeneca| US Postdoctoral Opportunity Oncology iMed- Enantioselective Synthesis| Enantioselective Synthesis of Quaternary Carbon Centers via Cross-Coupling of Aryl Boronates with Tertiary Alkyl Halides

The AstraZeneca Boston Oncology Medicinal Chemistry Group, located in Waltham, Massachusetts, is a team of synthetic organic, medicinal, computational, and analytical chemists dedicated to exploring the frontiers of science in order to improve patients' lives.

We are seeking a passionate, highly motivated, creative, and independent chemist to join our team as a post-doctoral research fellow to explore novel carbon-carbon bond forming reactions that will enable the construction of quaternary carbon centers, allowing efficient access to important and interesting molecular architectures.

Our state of the art research facility in Waltham, MA is an ideal location for someone who is interested in gaining experience in the pharmaceutical industry. There are ample opportunities to interact with drug discovery scientists across many drug discovery disciplines (Biology, DMPK, Toxicology, and Translational Science) as well as two major therapeutic areas (Oncology and Infection).

Candidate Focus and Challenge

All-carbon quaternary centers are important structural motifs in many classes of natural products and can impart beneficial properties to pharmaceuticals. However, extensive and frequent utilization of the all-carbon center in industrial and academic settings is hampered by the lack of general synthetic methodologies to construct them. Moreover, enantioselective variants of these processes are sparse. The goal of this project is to enable the enantioselective synthesis of quaternary carbon centers via transition metal mediated cross-coupling of an aryl metal species with suitable tertiary electrophiles.

Primary Objectives

• Develop a ligand-transition metal based catalytic system that can effect carbon-carbon bond formation between an aryl metal species and a tertiary electrophile to form quaternary carbon centers.
• Enable the enantioselective construction of all-carbon quaternary centers using optimized chiral transition metal-ligand complexes.
Secondary Objectives
• Demonstrate the utility of the catalyst system to synthesize quaternary centers in the context of polyfunctional complex molecules.
• Inspire and influence internal and external chemists to use this reaction to install all-carbon quaternary centers though interactions with internal project teams, external conference presentations, and publications.
• Major Responsibilities
• Develop novel synthetic methodology to enable the enantioselective construction of quaternary carbon centers via transition metal mediated cross-coupling of an aryl metal species with suitable tertiary electrophiles.
• Design, synthesize, and optimize chiral ligands and novel ligand-metal complexes to construct quaternary centers with high enantioselectivity.
• Synthesize a range of suitable aryl metal species and tertiary alkyl electrophiles to explore the substrate scope of the catalytic process.
• Demonstrate the utility of this methodology in the context of polyfunctional molecule synthesis by performing an enantioselective total synthesis of a small natural product or pharmaceutical bearing a quaternary carbon.
• Work collaboratively with other internal and external experts in the field of transition metal catalysis to design and evaluate catalyst systems.
• Show strong initiative in developing ideas and bringing them to functional use within AstraZeneca and externally.
• Interface with scientists from across many disciplines while also being able to work independently.
• Communicate results both by presenting to global working groups within AstraZeneca and externally at conferences.
• Publish scientific papers in peer reviewed journals describing the discovery of novel reactions, along with substrate scope and mechanistic insights.

Candidate Knowle
1004899| Confidential| Senior Director, Clinical Research&Development Job| Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary/Scope:
The Clinical Research Physician, Hematology/Oncology will be instrumental in supporting the growth of the Solid Tumors organization as it continues to build the value of its current products and develop new products. The incumbent will have hands-on responsibility designing and executing clinical trials, and running programs focused on assigned therapeutic areas. and will exhibit a passion for Phases 1 through 3, including biomarkers, proof-of-concept and full development.

Core Responsibilities:
Design and optimize clinical trial design and ensure clinical trials meet ethical and regulatory standards.
Lead the Clinical Protocol Team, including interactions with discovery, safety, marketing, regulatory, research and other functions.
Write protocols that are in-line with the overall indication strategy.
Present at Investigators' meetings.
Conduct medical review and interpretation of efficacy and safety data from clinical trials.
Have responsibility for the quality, coordination, medical accuracy and timeliness of clinical study reports.
Work with other Therapeutic Area Heads and team members to prepare abstracts, manuscripts and presentations for external meetings as well as author clinical sections of regulatory documents (IB, IND sections).
Assist senior management to oversee quality, coordination and timeliness of clinical sections of INDs, Investigator Brochures, CTAs, ISS's, ISE's, and clinical expert reports.
Present and discuss data and findings at relevant team, governance, KOL and regulatory meetings.
Establish and maintain working relationships with Study investigators, key opinion leaders, academicians, and Celgene Senior managers and department heads across the corporation
Ensure adherence to GCP/ICH and Celgene Standard Operating Procedure (SOP) standards.
Maintain clinical and scientific awareness in area of expertise.
Guide and influence the distribution and management of Clinical Research Scientists
Manage lifecycle requirements and plans for designated indications.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

*LI-KM1

Qualifications
Prerequisites: Minimum M.D. or PhD degree and substantial medical/clinical training in hematology/oncology or a related field
Minimum 5 years of experience designing, leading and managing significant clinical trials in hematology/oncology
Direct industry experience is preferred; substantial experience working on industry-sponsored trials will be considered.

Key Requirements/Knowledge:
Minimum M.D degree and substantial medical/clinical training in Therapeutic Area or a related field.
Minimum 5 years of experience designing, leading and managing significant clinical trials in the Therapeutic Area
Direct industry experience is preferred; substantial experience working on industry-sponsored trials will be considered.
Demonstrated understanding of drug development process.
Knowledge of Good Clinical Practices (GCP), FDA regulations and guidelines, and applicable international regulatory requirements.
Experience in designing Clinical trial strategies to obtain regulatory approval.
Ability to provide scientific and clinical expertise to a clinical development program and evaluate scientific and clinical strategies for a product.
Ability to develop and evaluate strategies for the clinical development of a designated indication and to critically evaluate outside expert advice.
Experience in Clinical project planning.
Experience working on global and complex Clinical trials.
Experience working effectively in a team/matrix environment.

Celgene Leadership Competencies
Drive Innovation
Shape Strategy
Attract and Develop Talent
Promote Open Communication
Create Global Mindset
Demonstrate Adaptability
Foster Risk Taking
Foster Teamwork

Competencies /Skills
Strong scientific/technical skills
Strong interpersonal capabilities and ability to build networks
Ability to anticipate and resolve problems
Ability to lead cross functional efforts and teams
Excellent verbal communication and technical writing skills
Ability to present clearly using scientific and clinical terminology
Excellent interpersonal skills and ability to communicate effectively with people in different functions
Sound organizational skills
Possesses sense of urgency and can take initiative
Ability to motivate team members
Project management skills and focus on delivery of results

Req ID:
Primary Location: United States-New Jersey-Summit
Job: Medical Operations
Organization: Celgene Corporation
Schedule: Regular
Shift: Standard
Employee Status: Director
Job Type: Full-time
Job Level: Day Job
Travel: Yes, 20 % of the Time
Job Posting: 2014-04-:00:00.0
1004943| Upstream| Hadoop, R, Python, Data Scientist - London - Unique opportunity!|

Hadoop, R, Python, SQL, PhD, SAS, SPSS, Omniture, Hive, Java, Matlab, London.

Data Scientists! 

One of London's most recognised brands that is growing at an exponential rate with a large FTSE100 client base. They have ambitious plans underway to significantly grow their £400 million business globally.

The evolution of their data science capability is crucial in order to achieve this goal.

They are building out a state of the art data analytics hub that will allow them to offer a superior service to their customers through a better understanding of personalised content, based upon behaviour both with them and elsewhere online.

They're looking for commercially astute and technically excellent Data Scientists to join their nascent analytics team and develop predictive algorithms, and conduct cutting-edge research into consumer behaviour on web, apps, and other transactional data.

This is an opportunity to conduct sophisticated analysis into consumer behaviour using their extensive databases.

You will be clever and motivated, with successful experience of applying statistical modelling and machine learning techniques to data analysis problems. As part of their newly created team, you will help to create understanding of their ever growing dataset, working in Tandem with other areas of the business to ensure they have an advantage over competitors by better understanding their customers.

You will also work closely with the board on internal strategic analysis projects such as workforce optimisation, demand forecasting and analysis for new global markets that they plan to enter.

You will be...

  • Joining a fast growing company and even faster growing team with abundant opportunities to make a clear and real impact to the company's direction.
  • Conducting pure analysis and research and swiftly translating that analysis into real commercial projects.
  • Building statistical models and applying machine learning/artificial intelligence techniques to understand consumer behaviour.
  • Conducting predictive modelling of various customer behaviours in order for a better understanding of web personalisation - when, why and which messages are served to different customers.
  • Carrying out strategic analysis projects for the purposes of new market entry, country and competitor analysis, potential acquisition analysis.
  • Applying data and analysis to operational and market strategy
  • Evangelising data and analysis within the business and presenting your insight to the board.

REQUIREMENTS

Your experience will encompass some of the following:

  • A PhD with a large data-analysis and statistics component (eg Physics, Machine Learning, Genetics, Mathematics, Operations Research etc)
  • An MSc in Applied Statistics, Machine Learning or similar.
  • 2 years minimum commercial data science experience
  • Data analysis experience on large datasets
  • Experience applying statistical techniques and machine learning algorithms to extract insights from real data
  • Experience applying Bayesian statistical techniques is highly desirable
  • Strong technical experience encompassing some of the following: Hadoop, R, Python, Hive, SPSS, SAS, SQL, Matlab, Omniture/Google Analytics and Java.
  • Ability to clearly communicate complex analytical and research findings to non-technical colleagues.

What's on offer

  • Aside from the opportunity to solve complex problems and conduct interesting analysis within an exciting sector that is experiencing huge disruption, you will also:
  • Be working within a dynamic and newly created team.
  • Due to its size, you will have the opportunity to make a huge impact on the company's strategy and operations.
  • Excellent career potential as part of a fast growing company that is also the European market leader.
  • Work with a smart and motivated peer-group.
  • Be part of an organisation that will grow on a significant scale internationally over the next 3 years.
  • Receive a generous salary and benefits package with realistic performance bonuses.

KEY: Hadoop, R, Python, SQL, PhD, SAS, SPSS, Omniture, Hive, Java, Matlab, London.

1004747| The Wellcome Trust Sanger Institute| [Senior] Software Developer: Medical Genomics|

An exciting opportunity has arisen for a Software Developer (or Senior Software Developer depending on experience) to work in Dr. Jeffrey Barrett's team at the Wellcome Trust Sanger Institute. We use computational and statistical methods to analyze some of the largest genetic datasets in the world to better understand the causes of a wide range of human disorders, including inflammatory bowel disease, susceptibility to tuberculosis, intellectual disability and autism.

This multifaceted role involves software development on open-source applications built for analysis of genomic data, scripting and analysis of big datasets, and design and implementation of the team's databases and software repositories.

Highly skilled developers are encouraged to apply regardless of prior job experience, as the focus is on coding and core computer science skills rather than on work experience. Recent graduates or current students in their final year are also encouraged to apply, although it is essential that any candidate has substantial development experience outside of coursework (e.g. active participation in open source projects or the pursuit of personal coding projects).

The successful applicant will have access to Sanger's world-class computational resources, including a 10,000+ core computational cluster and multiple petabytes of high-speed cluster filesystems (including over two petabytes of storage dedicated for human genetics use). Our work is also supported by an extremely knowledgeable and proactive systems group that maintains the core hardware and software infrastructure, and a five-person human genetics informatics team building pipelines shared across the department.

Essential Skills

*BSc/BA in a computational or quantitative science disciplin
*Strong background in computer programming, with experience in both large scale project development and smaller scripting tasks (e.g. via awk/perl/python)
*Knowledge of core development concepts (e.g. object oriented design, version control)
*Experience in UNIX computing environments
*Capacity for self-organization, timeline estimation, and teamwork

Ideal Skills

*MSc/MPhil/PhD in a computational or quantitative science discipline
*Knowledge of computer science concepts (e.g. machine learning, hidden markov models)
*Experience using high performance compute farms
*Interest or experience in human disease genetics or medical genomics
*Desire to contribute to genomics research
*Experience with large scale (terabytes or more) data processing

Other information

More information can be found at: wp.sanger.ac.uk/barrettgroup/

The Genome Campus is a 100-acre estate south of Cambridge in the grounds of Hinxton Hall. Nestled in the quiet countryside of these landscaped gardens, are two world-class research facilities: the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EBI). The site has become the British hub of biomedical science. The Campus is also home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and Annual Leave 25 days plus Bank Holidays.

Salary range for Software Developer: 23,573 to 29,714pa

Salary range for Senior Software Developer: 30,196 to 38,088pa

Closing date: 25th April 2014

1004952| Radley James Ltd| Data Scientist|

I am seeing a distinguished and highly talented statistician and data scientist's who enjoy exploring data, creating analytical tools and methods, and producing solutions while improving them for a world leading fund.

With a mathematical and scientific approach, intertwined with some of the most technically advanced systems in the city, the fund has formed the Science team consisting of world class business minds and scientists to drive transformational change through evidence-based decision making at the fund.  

Previous successful candidates have graduated from Russell group Universities or similar with a PhD or and MSc in applied Sciences (Machine learning, Mathematics, Computer Science, Artificial intelligence, Physics). As well as 3-5 years work experience within a research and technology environment.

For further information in complete confidence, please do not hesitate to call or email me

5476| University of Edinburgh, School of Informatics| 3-year Research Assistant (Early-Stage Researcher) position- ESSENCE (Evolution of Shared SEmaNtics in Computational Environments)| We have an opening for a three-year Research Assistant (Early-Stage Researcher) position as part of the ESSENCE (Evolution of Shared SEmaNtics in Computational Environments) Marie Curie Initial Training Network, a 4-year international collaborative research training project coordinated by the University of Edinburgh. This is a high-profile position that offers exceptional benefits ideally suited for top graduates.

This position is based in the Centre for Intelligence Systems and their Applications in the School of Informatics at Edinburgh. You will join an established research team with interests in automating representational change, ontology matching, automated reasoning and semantic web technologies. You will be expected to work with other investigators of the network, both at Edinburgh and at the other network nodes.
The post is available from 1st September 2014 for 36 months

Research training project
It is difficult for organisations to automatically query data developed externally and integrate that data into their own systems, because they will not be mutually compatible, using different terminology, schemas and formats. Currently, the process of utilising external data is usually done manually, either through direct human-to-human contact, with no automated use of the data, or through manual integration of the data, a process that is extremely time-consuming and requires a high level of expertise from the user. The focus of this project is on increasing the level of automation in this process. There are several steps to this process: for example, selecting appropriate data sources; aligning the schema of the data source with that of the central repository; disambiguating attributes; visualisation of data.

Candidate profile
You will have an excellent first degree or masters in Computer Science or a related subject. You will have some experience both in addressing theoretical issues and in implementation, with good programming skills. Ideally, you will have a background in one or more of the following: artificial intelligence, formal logic, knowledge representation and reasoning. Academic excellence will be given precedence over specialisation in these specific areas.

The ideal candidate will have an ability to formalise, analyse, implement, and evaluate intelligence systems, and experience in designing reasoning algorithms and heuristics. Substantial programming skills are needed to produce and test prototypical implementations. You will have excellent teamwork and communication skills, and be enthusiastic about collaborating with a diverse range of international partners and emergency responders.

Salary Scale: £31,924 (if opting in to the pension scheme) or £35,462 (if opting out of the pension scheme).

Vacancy Ref: 027773

Closing date: 24 April 2014

https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.jobspec?p_id=027773
1004963| Request Technology| Manager of Big Data|

The Role:

The Role of IT Management is to lead the IT organization by: fostering the development of a common vision; providing clear direction and priorities; clarifying roles and responsibilities; recognizing and removing barriers to progress; encouraging and empowering others to achieve; creating enthusiasm and a desire to excel; accurately assessing the strengths and development needs of team members; giving timely, specific feedback and coaching; providing challenging assignments and opportunities. A Manager is responsible for providing leadership to the organization by growing him/herself, growing others and growing the business.

Responsibilities:

  • Translate business problems into analytical framework and insights back into actionable recommendations
  • Manage, lead and execute complex projects independently from end-to-end
  • Work with cross-functional teams to deliver on the complex projects
  • Balance big picture vs finer nuances needs during the execution of projects
  • Frame the right questions to the Business Stakeholders and draft specific recommendations for the Business Stakeholders
  • Manage competing priorities and expectations
  • Work in a fast paced and challenging environment rooted in quick execution and iterative learning philosophy

People Management:

  • Builds long-term relationships within team and amongst peers by creating an environment of safety and innovation
  • Champion's open and honest communication
  • Respects confidentiality
  • Leads by example with integrity
  • Welcomes new ideas, learns from successes and failures
  • Models and creates an environment of accountability for direct reports and peers
  • Establishes vision, direction, and specific objectives for team efforts; allows freedom to accomplish objectives
  • Collects staff performance data against desired outcomes and service level agreements
  • Executes HR-related processes and develops staff through coaching and mentoring and providing specific, timely, open, honest, and constructive performance feedback.
  • Leads employees and influences peers through change by using one's self as an example.

General Management & Decision Making:

  • Sets and executes team strategy, including objectives, plans and policies for area of responsibility so as to develop and deliver innovative solutions and systems in support of Enterprise goals.
  • Communicates strategy to the team so they understand their role in achieving the established goals.
  • Manages day to day work of employees by monitoring budgets, expenses and scope and facilitating project delivery and support for complex projects of critical importance.
  • Works closely with decision makers in other departments to identify, recommend, develop, implement, and support cost-effective technology solutions for all aspects of the organization.
  • Makes decisions that have an impact on quality or effectiveness of business activities beyond their immediate team.
  • Initiates and implements continuous improvements in all areas of IT responsibility.
  • Anticipates issues and develops preventive measures.
  • Analyzes long-term impact of new or anticipated strategies and contributes to the business and functional strategy.

Business Partner Management:

  • Influences direct reports, clients, service providers and peers to successfully deliver on business commitments.
  • Partners with others in their organization to set and manage expectations; continually seeks opportunities to be a thought partner and increase internal business partner satisfaction and deepen relationships.
  • Negotiates solutions for issues that may be complex or controversial.
  • Adapts communication approach for audiences at multiple internal and external levels Develop and/or confirm detailed estimates for moderate to high complexity projects.
  • Monitor, document and communicate the technical progress of the project.
  • Use knowledge of integrated requirements to evaluate proposed software products.
  • Facilitate the resolution of complex system deficiencies with the design team and project management. Support the business in researching technical questions.
  • Work with other teams in coordinating changes across system. Create Proof of Concepts (POCs).
  • Support the planning, conduct, and review of module and integration testing for moderate to high complexity projects.
  • Prepare the staging and development of complex test environments and conditions.
  • Consult on the content of functional test conditions for assigned applications, projects, etc.
  • Support data analysis and validation from functional tests.
  • Resolve complex issues reported by Product Quality Services from a technical standpoint.
  • Work with Quality Control teams in identifying root cause of complex issues.
  • Identify and investigate potential scope changes and other issues related to technical design.
  • Provide change request direction for multiple areas of expertise.
  • Support the change analysis for design, code and other artifacts.
  • Identify and recommend technical process improvements. Develop and maintain complex technical process and application process flows.
  • Maintain awareness of vendor products and suggest uses or improvements to business.
  • Review operations, environment, and desktop documentation. Gather input from other appropriate team members to create documentation.

Qualifications:

  • 5+ years people or technical leadership or equivalent experience leading a team or working in a team oriented collaborative environment
  • 5+ years of experience in performing Statistical Modeling, Data Mining and/or Machine Learning to solve business problems
  • BS/MS/PhD or other relevant technical degree
  • Very strong big data ETL processing including map reduce, pig, hive
  • Command over a Statistical Modeling/Data Science tool like SAS, R or Python
  • Command over wide array of Analytical techniques and be able to decide which technique will yield required results most efficiently
  • Strong analytical skills, problem solver, and attention to detail
  • Results driven and ability to coordinate and prioritize multiple tasks in a fast-paced environment
  • Motivated self-starter who can take charge of complex tasks with limited direction
  • Strong verbal/written communication and presentation skills
  • Build relationships and work effectively with cross functional team
1004954| Celgene Corporation| Senior Director, Analytical Development Job| Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

Position Summary
This leadership position is responsible for leading the scientific/technical efforts of analytical development scientists responsible for physical and chemical characterizations, method development, validation, implementation, testing/reporting, and methods transfer to support the clinical development product pipeline for pharmaceutical small molecule drug substance and drug product manufacturing process and product development and regulatory filings. The scope of responsibility spans discovery candidate lead optimization and continuing through pre-clinical, clinical, commercial and life-cycle development programs.
This position works collaboratively with the other pharmaceutical development functions and contributes to product development plans, timelines and deliverables. The position interfaces with internal stakeholders, external development partners and third party service providers.

Responsibilities include, but are not limited to, the following:
Directs the overall scientific, technical and laboratory efforts of the Analytical Development method development groups responsible for analytical characterizations, development/validation of analytical methods for small molecule drug substance and drug product, release and stability testing and method transfers to manufacturing sites.
Leads a high-performing team of analytical scientists who are cross-functionally aligned with Pharmaceutical Development Compound Teams, strategies and priorities to ensure individual development candidates are advanced to meet global project requirements and corporate objectives.
Ensures the department works as a productive development partner with collaborators and teams; facilitates the generation of and interpretation of data, and the development of product and process knowledge, quality attributes, stability profiles and specifications.
Identifies analytical science capabilities and technology tools needed to enable pharmaceutical manufacturing process development and understanding of development candidates and their quality and performance attributes.
Applies scientifically-driven thinking and supports the development of scientifically sound, well understood and robust manufacturing processes during the development and scale-up phases.
Supports and develops the scientific and technical capabilities of the function and the development of scientific and management staff.
Leverages scientific and pharmaceutical development knowledge and cross-functional experience to drive collaboration, interpretation of data to inform decision-making and value to Celgene.
Works in collaboration with development and manufacturing colleagues to implement analytical controls, and support manufacturing and testing at CROs.
Develops, ensures the delivery of high quality-related documentation to meet global regulatory expectations for analytical methods and controls. Delivers analytical source documentation for CMC sections of IND/CTA/NDA filings for Celgene NCEs. Addresses technical inquiries from regulatory agencies to support clinical trial and commercial marketing applications.
Provides input to the development of project strategies, budgets, timelines, and product development plans. Helps ensure that scientific and business expectations are met.
Collaborates with Discovery, Non-Clinical, Drug Substance and Drug Product Development groups to define drug candidate physico-chemical and quality attributes, testing methods, stability profiles, product performance characteristics, and specifications.
Builds and maintains strong working relationships with colleagues in Research and Development, Regulatory CMC, Quality, and Technical Operations as well as alliance partner counterparts, as applicable.
Provides committed and inspiring leadership, stewardship and advocacy, striving for scientific understanding, process knowledge development, continuous improvement, acceleration, risk assessment and mitigation, resource allocation and support, as appropriate.
Participates in due diligence assessments of potential business development interests, with ultimate responsibility for ensuring attention to small molecule analytical considerations.
Create an environment that attracts, develops, retains and promotes diverse scientific, technical and management talent
Direct management of personnel including performance appraisals, promotions, salary administration, staff hiring, mentoring, and other personnel related activities.
Planning and management of departmental operating and capital budgets for internal and external expenses, and resources to accomplish these responsibilities and objectives on an ongoing basis.

Leadership:
Creates an impactful vision for the function and communicates a supporting strategy to align people, resources and management.
Sets high performance expectations and holds others accountable for the results expected.
Promotes a culture of scientific excellence, multidisciplinary problem solving, teamwork, consistency, flexibility, execution, quality and effective communication.
Encourages new ideas, technologies, processes, and approaches.
Builds a collaborative, supportive learning environment with a focus on driving a scientifically-based product development strategy that is aligned with development and business needs across the development to commercial continuum.
Influences and impacts others through building and maintaining strong networks that are leveraged to obtain critical information and accomplish objectives.
Anticipates needs, assesses and manages business risks and organizational dynamics as well as their implications.
Recognizes and resolves broad based complex issues across organizational boundaries.

*LI-KM1

Qualifications
Skills/Knowledge Required:
Ph.D. in Analytical Chemistry, Pharmaceutical Chemistry or related scientific discipline. 15 + years experience in the pharmaceutical industry with increasing scientific and leadership responsibilities in analytical development
Demonstrated scientific knowledge and experience in analytical science /organic chemistry in drug development and associated analytical requirements throughout the discovery/development/commercial continuum
Demonstrated broad knowledge and experience in the development and validation of test methods for small molecule API and drug product candidates, physical and chemical characterizations, general analytical analysis, assay/impurity analysis, dissolution testing, and specifications development.
Broad knowledge of the pharmaceutical development and commercialization process
Established knowledge of applicable global drug development and regulatory standards and current expectations
Knowledge and application of cGMPs/GLPs, DEA regulations, ICH, FDA CMC Guidance Documents
Experience with CMC technical sections of regulatory submissions and addressing regulatory authorities on technical matters
Experience in technology transfer of test methods to internal manufacturing sites and external CMOs
Strong analytical and strategic thinking
Demonstrated scientific and problem solving capabilities and cross functional understanding
Experience in budget planning and oversight
Excellent communication skills (oral, written, presentation)
Demonstrated experience managing technical professionals including PhD staff, with a track record of fostering staff development
Demonstrated skills building and maintaining productive relationships with organizational counterparts such as Discovery, Toxicology, Drug Substance Development, Drug Product Development, Technical Operations, Quality, and Regulatory CMC
Demonstrated situational leadership skills (e.g. teambuilding, facilitation, conflict resolution, persuasion, negotiation)

Req ID:
Primary Location: United States-New Jersey-Summit
Job: Analytical Research&Dev
Organization: Celgene Corporation
Schedule: Regular
Shift: Standard
Employee Status: Director
Job Type: Full-time
Job Level: Day Job
Travel: Yes, 10 % of the Time
Job Posting: 2014-04-:00:00.0
5493| Cardiff University, School of Healthcare Sciences| Research Assistant (Rehabilitation)| The School of Healthcare Sciences, Cardiff University, conducts high quality research relevant to the clinical practice of nurses and allied healthcare professionals.

We are seeking a well-organised, motivated and flexible Research Assistant to contribute to research within movement analysis and virtual rehabilitation, carrying out supporting work that helps lead to the publishing of research in high-quality journals. The role holder will pursue excellence in rehabilitation research and inspire others to do the same.

The post holder will hold a BSc or MSc in a relevant field related to movement therapy, rehabilitation or movement research or equivalent experience. They will have good computer skills, particularly data acquisition, spreadsheets, word processing as well as proven communication skills including effective communication with patients.

Informal enquiries about the post may be directed to Professor Robert van Deursen, Professor of Rehabilitation Science (vandeursenr@cardiff.ac.uk).

This is a part-time post (0.5 FTE; 17.5 hours per week) and is fixed-term for twelve months from 1 May 2014 (or as soon as possible thereafter)

Applicants requesting external secondment from an NHS Health Board or Trust will be considered.

Salary range: £25,013 - £28,972 per annum, pro-rata for hours worked (Grade 5)

Date Advert Posted: 10 April 2014

Closing Date: Friday, 25 April 2014

Cardiff University reserves the right to close this vacancy early should sufficient applications be received.
5464| University of Western Sydney, Hawkesbury Institute for the Environment| Postdoctoral Research Fellow in Environmental Microbiology| Appointment: 3 year appointment

Level: Academic Level A Step 3 - 4

School/Office: Hawkesbury Institute for the Environment

College/Division: Academic and Research Division

The Hawkesbury Institute for the Environment at the University of Western Sydney conducts fundamental and applied research in a range of areas that include soil microbiology, plant-soil interactions, genomics and bioinformatics, plant physiology, climate change biology, and plant-environment interactions.

A Postdoctoral Research Fellow in Environmental Microbiology is available for an active, dynamic individual with expertise in the broad areas of metagenomics, meta-transcriptomics, plant-microbial interaction, nutrient cycling and bioremediation research. The successful candidate will require molecular microbial ecology and bioinformatics skills as well as experience in establishing laboratory microcosms.

The position is available for 3 years with the possibility of extension thereafter pending continuing funding.

Web: www.uws.edu.au/hawkesburyinstitute

Remuneration Package: Academic Level A $91,289 AUD to $96,851 AUD p.a (comprising Salary $77,140 AUD to $81,840 AUD p.a. plus 17% Superannuation and Leave Loading)

Position Enquiries: Professor Brajesh Singh, +61 2 4570 1329, b.singh@uws.edu.au

Closing Date: 4 May 2014

How to Apply: Go to the web site http://uws.nga.net.au/cp/ and scroll to the job reference 397/14. Click on the reference number and follow the instructions at the bottom of the page on ‘How To Apply’.
5504| AstraZeneca| US Post Doctoral Opportunity: Impact of allele specific expression on oncogene dependency| Explore the impact of allele specific expression on oncogene dependency and drug response

Our newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines. We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca's commitment to delivering innovative medicines.

Our comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists. Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.

Job Description:
Candidate Focus & Challenge:
• Acquire and analyze next generation sequencing (NGS) data from cancer samples to understand the landscape of allele specific expression of oncogenes and tumor suppressors
• Explore the impact of allele specific expression on oncogene dependency and drug response
• Develop novel algorithms or methods, if necessary, for analyzing NGS data
• Work closely with scientists from across many disciplines while at the same time being able to work independently
• Communicate/present results both within AstraZeneca via global working groups and externally at meetings and through publications
• Publish scientific papers in high impact journals

Candidate Knowledge, Skills & Experience:
• Must have a Ph.D. in bioinformatics, computational, statistical, or a related scientific discipline
• First-hand experience in analyzing next generation sequencing data, particularly in DNA and RNA-seq
• Experience in interpreting NGS and 'omic data
• Hand-on experience in scripting languages such as Perl, Python, or shell script
• Familiar with statistical analysis using R or Matlab for hypothesis testing
• Experience in both Windows and Linux environment
• Strong interpersonal, organizational and communication skills
• A strong scientific track record, as evidenced by published or accepted papers, as well as oral or poster presentation at scientific conferences
• Strong passion & commitment to science, and ability to work well within a group/team environment
• Knowledge of oncology and drug discovery

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Closing date 9th May
Location: Waltham, USA

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