This is a full-time post funded by a BBSRC Research Grant in partnership with GSK. The postholder will develop and explore the utility of automated fluorescence microscopy based assays of cell signalling processes in 3-D cultures using Fluorescence Lifetime Imaging (FLIM) and Forster Resonant Energy Transfer (FRET) based readouts.
The postholder will work with Chemistry and Life Sciences-based colleagues at Imperial and GSK to develop and apply new assays utilising innovative FLIM multiwell plate readers being pioneered in the Physics Department.
The successful applicant will have a background in cell biology and experience of fluorescence microscopy, with expertise in cell culture and fluorescence labelling techniques, including the use of antibody-based probes and genetically expressed fluorophores, and the analysis and interpretation of fluorescent microscopy data. They must have an understanding of cell signalling processes and of the techniques used to study them, including biochemical and molecular techniques. Experience of 3-D cell cultures and assay development is highly desirable, as is experience in high content analysis and particularly techniques for fluorescence-based assays
The applicant must hold a PhD or have equivalent experience in Cell Biology/Physiology and a degree or equivalent experience in Biology or Biochemistry.
More information concerning our research can be found at:
http://www3.imperial.ac.uk/photonics/Our preferred method of application is online via our website
http://www.imperial.ac.uk/job-applicants (please select “Job Search” then enter the job title or vacancy reference number into “Keywords” - vacancy ref NS2015074SA). Please complete and upload an application form as directed, also provide a CV including a list of publications.
