We are looking to appoint a postdoctoral scientist to join the research group led by Kaan Boztug at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences.
The focus of the group is to understand the molecular mechanisms governing the human immune system by discovering disease-causing gene mutations and studying the resulting pathomechanisms. Ultimately, understanding the immune response at the molecular level will lead to better treatment options (for some recent publications see e.g. Salzer E et al JACI 2014, Boztug K et al Nature Genet 2014, Willmann K et al Nature Communications 2014).
The Project
Inherited defects of the human immune system (so-termed “primary immunodeficiencies”, PIDs) represent unique models to dissect essential components of the immune system in natura. A considerable number of PIDs, as well as many other human diseases are characterized by autoimmunity or autoinflammation. However, the molecular mechanisms are often poorly understood. Using NGS-based methods, we have recently identified a number of novel PID candidate genes. The project aims at studying in detail the role of the identified genes in the underlying disease mechanisms by a variety of biochemical, immunological and imaging technologies to obtain molecular gene-to-phenotype relationships. Functional proteomics will be used to mine, uncover and pathway-map gene defects underlying inherited disorders of the immune system with predominant autoimmunity/autoinflammation.
The Lab Infrastructure
A fully equipped molecular biology laboratory in a shared environment with cell culture and multi-color flow cytometry on the same floor within a brand new building. All equipment needed for state-of-the art genomic investigations such as SNP arrays and deep sequencing are immediately accessible on the same floor of the building. The group is embedded in a multidisciplinary and highly collaborative systems biology/molecular medicine research environment providing access to state-of-the-art mass spectrometry, bioinformatics, automated chemical biological screening platform and animal facilities, including BSL2 suites.
The Employment Package
Gross salary according to the FWF salary scheme (
http://www.fwf.ac.at/): EUR 3483,- (payable 14 x per year)
Insurance package (health, accident, pension and unemployment insurance)
Bonus for in-house cafeteria
Your Requirements & Application
You should have a strong background in one or more of the following disciplines: Immunology, Genetics, Medicine or Molecular Biology, and need to hold a PhD (respectively DVM/MD or equivalent) degree. The ideal candidate will have an excellent work ethic and very good communication skills. Enthusiasm, self-motivation, creativity as well as a proactive approach to solving problems and developing new ideas are highly desirable. We are looking for a candidate who is able to connect different scientific disciplines and think outside the box.
Please send your application documents (cover letter, CV, contact details of your supervisor and two additional referees) to
[email protected] using the reference code #KB15.
Closing date for applications: 26 February 2015
Join CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, in its wonderful, new building in the middle of the Medical University campus in Vienna. According to a study by “The Scientist”, CeMM is one of the best places in the world to do a postdoc (
http://the-scientist.com/2012/03/29/best-places-to-work-postdocs-2012/) and it is one of the Best Places to Work in Academia 2012 worldwide (
http://goo.gl/51VMO). Vienna, located in the heart of Europe, has been consistently ranked among the 3 best places to live worldwide.
Find out more about us:
www.cemm.at
