We seek to appoint a Postdoctoral Training Fellow to the research team led by Dr Sebastian Guettler in the Divisions of Structural and Cancer Biology. Work in the Guettler laboratory centres on the elucidation of signal transduction mechanisms relevant to the function of cancer cells, in particular the Wnt/-catenin network and telomere homeostasis and their control by poly (ADP-ribosyl)ation. We take a multi-disciplinary approach that combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells. For a recent publication, please see Mariotti et al. (2016). Molecular Cell 63, 498–513. Additional information is available at
http://www.icr.ac.uk/our-research/researchers-and-teams/sebastian-guettler.
You will undertake biochemical, structural and functional studies on macromolecular complexes controlling the maintenance and integrity of telomeres, and their regulation by poly(ADP-ribosyl)ation. A central component of the research project will be the structural analysis of large multi-protein assemblies by cryo-electron microscopy.
You should possess a PhD in a biological science such as biochemistry or molecular biology and have experience with single-particle electron microscopy. In addition, experience with recombinant DNA techniques, high-quality protein expression and purification, protein characterisation, such as protein-protein interaction analyses, is essential. Experience in protein production in insect cells would be advantageous.
Appointment will be on a Fixed Term Contract for 3 years. The full salary scale is in the range from £29,960 - £42,820 p.a. inclusive. Starting salary will be based on postdoctoral experience.
To apply, please click below to submit your CV and covering letter online. In your covering letter, please address with specific examples where you meet the person specification and summarise your research interests and motivation for applying. Please include the names and addresses of two referees.
Job Ref. No.: 90
Closing date: 18th August 2017
Informal enquiries can be made to
[email protected]. Please do not submit your formal application by email; applications must be submitted in line with the instructions above.
Research in the Divisions of Structural Biology and Cancer Biology focuses on the functional, biochemical, and structural characterisation of cellular processes relevant to cancer and cancer therapy. The Division of Structural Biology has managed facilities for protein production, with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60-litre fermentor), protein crystallography (crystallisation robots, Bruker Microstar and CCD detector) and cryo-electron microscopy (FEI Tecnai F20 and T12). Regular access to shared cryo-electron microscopy facilities, such as eBIC, is available. Moreover, the Institute of Cancer Research will be part of the London Consortium for Cryo-Electron Microscopy, hosting an FEI Titan Krios cryo-electron microscope equipped with a Volta phase plate, a Falcon III detector and a Gatan Bioquantum energy filter and K3 detector. The Division is also well-equipped with instrumentation for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering).
The Division of Cancer Biology provides a state-of-the-art infrastructure for mammalian cell culture, light microscopy, mammalian genetics, chemical biology and proteomics.
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes. We provided the first convincing evidence that DNA damage is the basic cause of cancer, and today lead the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.The Institute of Cancer Research (ICR) came top in the league table of university research quality compiled from the Research Excellence Framework (REF 2014). Based on our publication record, citations and impact, we rank among the world’s leading cancer research centres. As a college of the University of London, the ICR provides postgraduate higher education of international distinction. We also have charitable status and rely on support from partner organisations, charities, donors and the public. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer
