FRANKLIN Themes: Next Generation Chemistry
Project: EUbOPEN consortium: chemical probe development
Location: Harwell
Grade and salary: £33,000 – £39,000 per annum
Hours: Full-time (part-time working possible)
Contract type: 18 months’ fixed term contract
Reporting to: Head of High-throughput Molecular Discovery (Professor Adam Nelson)
Vacancy reference: 10155
Additional information: The role will support the development and execution of high-throughput synthesis methods to accelerate the discovery of chemical probes
The role
We are currently seeking a highly motivated postdoctoral researcher to join our team at the Rosalind Franklin Institute (the Franklin) as part of the EUbOPEN consortium: chemical probe development project. The €66M EUbOPEN consortium (
https://www.eubopen.org/), funded through the EU’s Innovative Medicines Initiative (IMI), has been established to enable and unlock biology through the availability of chemical probes. Within this consortium, the role of the Franklin is to develop methods that can accelerate the discovery of high-quality probes for diverse target proteins.
A high-throughput facility is being established by the Franklin to transform molecular discovery capabilities. The facility enables the development of efficient and integrated methods for automated microscale chemical synthesis, reaction analysis, product purification/formatting, and biological evaluation. As a technical specialist within the Next Generation Chemistry theme of Rosalind Franklin Institute, you will develop and execute high-throughput synthetic methods that can accelerate probe discovery. You will build on, extend and apply a toolkit of prioritised automated synthetic methods. Crucially, you will demonstrate that the methods can be applied to live chemical probe discovery projects within the EUbOPEN consortium. Your tasks will be largely associated with diverse equipment within the Franklin’s High-Throughput Molecular Discovery facility such as chemistry robotics, analytical LC-MS instruments and mass-directed purification equipment. You will collaborate with scientists from the University of Oxford’s Centre for Medicines Discovery as well as other researchers within the EUbOPEN project.
About you
Candidates must hold a PhD qualification (or close to completion), or equivalent experience, relevant to the synthesis of small-molecule chemical probes. We are looking for candidates with demonstrable practical experience of establishing and exemplifying synthetic methods of direct relevance to bioactive molecular discovery. Experience of ensuring that laboratory work is conducted safely and in accordance with statutory requirements and local regulations, as well as the ability to develop programming skills needed to control the facility’s instruments and to document experiments and protocols thoroughly and concisely, are essential for this role.
About us
The Rosalind Franklin Institute (the Franklin) is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology. Our work is focused into five complementary themes, which together will produce technologies which allow us to see the biological world in new ways, from single molecules to entire systems. This insight will speed up drug design and development, and push forward our understanding of human health and disease.
Location: The Franklin is based in Harwell Campus, UK’s innovation hub and well-established as one of the leading science and innovation campuses in Europe.
Before submitting your application please ensure you read the Job Information Pack for full details of this role by clicking on the attachment on our website:
https://opportunities.rfi.ac.uk/vacancy/postdoctoral-research-associate-in-high-throughput-chemical-synthesis-455014.html Closing date: 1st October 2021 at 09:00am
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