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Postdoctoral Research Associate



Centre for Stem Cells & Regenerative Medicine / Basic and Medical Bioscience
Grade 6/31, £38304 including London Weighting Allowance
Reference: 015844

The Centre for Stem Cells & Regenerative Medicine is located in Guy’s Hospital.
It is internationally recognized for research on adult and pluripotent stem cells and is a focus for cutting-edge stem cell research currently taking place across the College and its partner NHS trusts, as part of King’s Health Partners. Through the Centre, King’s aims to drive collaboration between scientists and clinicians to translate the potential of stem cells into clinical reality for patients.

Applications are invited for a postdoctoral researcher funded as part of the PIs Wellcome Clinical Fellowship, and will work with a dynamic group of scientists focussed on reproductive biology, early embryonic development and the causes of infertility. The post holder will contribute to the regenerative medicine theme and will be involved in the generation and processing of single cell experiments using a variety of techniques.

This is an exciting opportunity following our recent work (Sangrithi et al. 2017, Dev Cell & Lau et al. 2020, Dev Cell). The project aims to discover the function of genes on the X-chromosome in male germline stem cells (spermatogonia) and their role in idiopathic and sex chromosome aneuploidy associated infertility. We aim to understand physiological gene regulatory networks functional in spermatogonial stem cells using a combination of single-cell methods, to explain how perturbation in X-gene dosage in SSCs may cause infertility. The postholder will also identify and validate candidate disease bio-markers.
The post holder will be working in Dr Mahesh Sangrithi’s group.

This post will be offered on an a fixed-term contract until 05/04/2026

This is a full-time post - 100% full time equivalent
Closing Date: 28th February 2021

Apply link: https://jobs.kcl.ac.uk/gb/en/job/015844/Research-Associate-in-Stem-Cells-and-Regenerative-Medicine


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