The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (Leibniz-HKI,
www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics.
The department of Infection Biology invites talented and highly gifted candidates to apply as a
Postdoctoral Researcher (f/div/m) Complement Genetics & Glomerular Diseases
for two years initially.
Your profile:
• Doctoral degree in biology, genetics, microbiology or life sciences
• Experience, knowledge and good experimental skills in molecular biology, genetics, biochemistry
• Knowledge of complement and immunobiology, bioinformatics, cell biology and microbiology is an advantage
We offer:
The successful candidate will investigate the field of complement genetics, complement regulators and pathology of complement mediated kidney diseases.
Main topics of the project are:
• Identification of genetic mutations of complement genes in the renal diseases C3 glomerulopathy and atypical hemolytic uremic syndrome
• Next generation sequencing for genetic diagnostics and biomarker evaluation
• Functional characterization of FHR2 and FHR5 proteins in complement system and beyond; for further details please see literature below
The successful candidate will be hosted in the department Infection Biology of Prof Dr. Peter Zipfel. The Leibniz-HKI is embedded in the outstanding scientific environment of the Beutenberg Campus providing state-of-the-art research facilities and a highly integrative network of life science groups. We offer multifaceted scientific projects with excellent technical facilities, a place in a dynamic, committed team, as well as strong scientific collaborations.
Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer, the Leibniz-HKI is committed to increasing the percentage of female scientists and therefore especially encourages them to apply.
Further information:
Prof. Dr. Peter Zipfel | +49 3641 532 1301 |
[email protected]Applications:
Complete applications in English should include a cover letter, a CV containing a complete list of publications, a brief statement of research experiences, the addresses of two possible referees, and should be submitted by March 31, 2021, via the Leibniz-HKI online application system.
Literature:
Zipfel PF, Wiech T, Stea ED, Skerka C (2020) CFHR gene variations provide insights in the pathogenesis of the kidney diseases atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.
J Am Soc Nephrol 31, 241-256.
Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdaukas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C (2019) Factor H-related protein 1 (FHR1) senses necrotic cell stress and triggers sterile inflammation. Nature Communications 10, 2961.
Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Büttner M, Goodship T, Hugo C, Skerka C, (2014) Complement factor H related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124, 145-155.
Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740.
