The Mani Laboratory, housed in the Chanin Building (Inset), at the Departments of Medicine, Genetics
and Pharmacology and The Cancer Institute and Einstein-Mount Sinai Diabetes Research Center of The
Albert Einstein College of Medicine, INC has an open position for a highly motivated postdoctoral fellow
to be part of an expanding research program on novel aspects of the mammalian microbiome.
Laboratory Research Focus and Expertise: The laboratory is focused on the study of orphan nuclear
receptors, specifically the Pregnane X Receptor (PXR), that recognize xenobiotics ( and endobiotics) as
ligands and their effects on mammalian physiology and pathophysiology. Recently, we have shown that
microbial metabolites can serve as ligands for such receptors (Immunity, 2014). In more recent work,
in the study of these microbial ligands, we devised a biofilm assay that allowed for identification of new
and novel bacterial species/strains from the enteric microbiota. The goal now is to study all aspects of
the importance of these species to host physiology and pathophysiology (inflammation, cancer). These
studies will include delving into the mechanisms of host-microbe (and microbe-host) interactions.
Related research can expand to study of the mechanisms of bacterial biofilms using both genetic,
biochemical and biophysical approaches.
SEE:
http://www.einstein.yu.edu/faculty/5615/sridhar-mani/Postdoctoral Expertise Required:
1. Recent doctoral degree or equivalent ( e.g., M.D or M.D./Ph.D or Ph.D) and/or early
postdoctoral training exposure.
2. First author publication record from Ph.D
3. Emphasis placed on record of new methods development and analytical/reasoning skills &
curiosity driven investigations.
4. Prior experience in microbiome research and mouse work, and/or metagenomics,
and transposon/CRISPR based mutagenesis is preferred.
5. Strong reasoning, communication, visualization and written skills (English) are
preferred
Please e-mail your CV and cover letter focusing on your interests and goals, along with contact
information (and/or letters) from three referees to:
[email protected]The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.
Email us:
[email protected]PI127337555
