Our division is based at the ICR site from the charming London’s Chelsea district, offering a unique cultural environment and great opportunities for personal and professional development.
Funded by the Wellcome Trust, the post-doctoral position is available in the laboratory of Prof Vlad Pena. We are looking for a structural biologist with a keen interest in RNA biology.
The goal of the project is to understand how regulatory splicing factors act within spliceosomes to determine decisions in alternative splicing. The successful candidate will reconstitute multi-megadalton complexes relevant for alternative splicing and determine their structure by cryo-EM. The structures will be complemented with various functional assays. We will provide the support and guidance in the specific methods for assembly, purification and biochemical analyses of spliceosomes.
We provide routine access to state of the art facilities for structural biology, such as recombinant expression, protein purification, large scale mammalian cells cultivation, electron microscopy (Tecnai T12 and F20, Glacios and Titan Krios with state of the art detectors), high performance GPU computing, mass-spectrometry, preparative and analytical biochemistry.
Applicants should possess a PhD (or equivalent) in structural biology, have a good expertise in single-particle cryo-EM and in the biochemical investigation of macromolecular complexes. Experience in RNA biology would be an advantage, although it is not mandatory.
Appointment will be on Fixed Term Contract for 3 years in the first instance, with an expected starting salary of £37,850 p.a. inclusive (£32,844 for pre-viva applicants until they are rewarded PhD). Informal enquiries are welcome and can be made to Prof Vlad Pena (
[email protected]). Please note, this address is for enquiries only and you should not send your application to this email address.
To apply please submit online application on the ICR Careers site, attaching your CV with the supporting statement (addressing with specific examples where you meet the person specification, a brief description of your research experience and incl. the names and addresses of at least two referees).
After receiving the application, we will contact the suitable candidates as soon as possible. Job ref. 1161
Please note the closing date has been extended to 31 January 2021
