Post-doctoral position in PBPK modeling: Basel, Switzerland

A fully funded postdoctoral position (100%) is available in the Division of Infectious Diseases & Hospital Epidemiology at the University Hospital of Basel. The research project aims to develop physiologically based pharmacokinetic (PBPK) models to simulate dosing requirements of long-acting intramuscular antiretroviral drugs in special populations and to manage drug-drug interactions with concurrent medications. The PBPK approach uses in vitro drug data and a mathematical description of drug absorption, distribution, metabolism and elimination (ADME) to predict the pharmacokinetics in a virtual population. This research project is of particular clinical importance, as it will provide guidance on dosing requirements in special populations, which were not evaluated comprehensively during drug development but which may also benefit from this novel treatment paradigm aiming to improve the chances of life-long maintenance of HIV suppression. In addition, this project will provide a comprehensive knowledge of factors influencing intramuscular drug disposition and improve the knowledge on drug-drug interactions with this route of administration.
The candidate must have a PhD degree and experience in PBPK modeling using the simulation softwares Matlab, R. Knowledge about principles in pharmacokinetics and drug metabolism is desired.
This position is also open to candidates from the European Union and North America. The working language is English. German skills, although helpful, are not essential. Basel is a highly attractive city with a multinational population.
Application/contact
Please send one PDF file including CV with academic transcripts, publications, three academic references as well as a letter of motivation to:
Prof. C. Marzolini: [email protected]