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Post-doctoral Training Fellow - Cryo-EM Structural Biology

Our division is based at the ICR site from the charming London’s Chelsea district, offering a unique cultural environment and great opportunities for personal and professional development.

Funded by ICR, the German Research Foundation and Wellcome Trust, the post-doctoral position is available in the laboratory of Prof Vlad Pena, starting with November 15th. We are looking for a highly motivated and creative structural biologist with a keen interest in the field of gene expression, pre-mRNA processing and splicing.

The goal of the project is to understand how cancer-related mutations and antitumor drugs induce reprogramming of alternative splicing. To this end, we will reconstitute multi-megadalton complexes that capture splicing regulation in the presence of mutations and drugs, and determine their structure by cryo-EM. The structures will be complemented with various functional assays. We will provide the support and guidance in the specific methods for assembly, purification and biochemical analyses of spliceosomes.

We provide routine access to state of the art facilities for structural biology, such as recombinant expression in baculovirus and bacteria, protein purification, large scale mammalian cells cultivation, electron microscopy (Tecnai T12 and F20, Glacios and Titan Krios with state of the art detectors), high performance GPU computing, mass-spectrometry, preparative and analytical biochemistry.

Applicants should possess a PhD (or equivalent) in structural biology, have a strong expertise in single-particle cryo-EM, and be familiar with methods of preparative biochemistry of macromolecular complexes: recombinant expression, chromatographic methods. Experience in X-ray crystallography would be an advantage, although it is not mandatory.

Appointment will be on Fixed Term Contract for 3 years in the first instance, with a starting salary of £32,844 - £40,137 p.a. inclusive dependent on previous relevant postdoctoral experience. Future progression is based on annual performance review. Informal enquiries are welcome and can be made to Vlad Pena (). Please note, this address is for enquiries only and you should not send your application to this email address.

To apply please submit online application on the ICR Careers site, attaching your CV with the supporting statement (addressing with specific examples where you meet the person specification, a brief description of your research experience and incl. the names and addresses of at least two referees).

For more details, please refer to the job description and person specification, job ref 1104

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