Postdoctoral Scientist in Leukaemia Biology

THIS IS A RE-ADVERTISEMENT. PREVIOUS APPLICANTS NEED NOT APPLY.

This is an exciting opportunity for a highly motivated and ambitious Postdoctoral Scientist to join Professor Paresh Vyas and Irene Roberts at the MRC Weatherall Institute of Molecular Medicine (WIMM). The postholder will be based in the Vyas laboratory and work closely with both Professor Vyas and Professor Roberts.

The Vyas and Roberts laboratories are world-leading in the study of the biology of acute myeloid leukaemia using paediatric leukaemia as a model. We have focussed on the myeloid leukaemia in children with Down Syndrome who have a 150-fold increased incidence of leukaemia. Through a comprehensive study of the genetics, functional studies including CRISPR-based screens and targeted loss of function studies combined with single cell biology, in primary patient samples and in vivo models, the successful applicant will now dissect how multiple leukaemic mutations cooperate to perturb blood stem and progenitor cell differentiation, with the aim of understanding fundamental principles of how genetic and epigenetic change causes leukaemia and this will provide a platform for rational therapy.

You will hold a PhD (or near to completion: thesis submitted) in either leukaemia biology, study of haematopoiesis, or transcription factor function. A strong publication record in high-impact peer-reviewed journals (at least two second tier or one first tier first author publication(s)) is a prerequisite, as well as the ability to work independently and as part of a team. You will have excellent communication and organisational skills, with the ability to manage and independently drive, innovate and complete your own research and associated activities. Computational experience in analysis of transcriptomic and epigenetic datasets is desirable.

This a fixed position ending on 31st May 2023, funded by Blood Cancer UK.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is noon on Monday 7 September 2020.