Applications are invited for a temporary post of a UCD Post-Doctoral Research Fellow Level 1 or 2 within UCD School of Medicine/Charles Institute of Dermatology.
The UCD Charles Institute of Dermatology has an ongoing research programme led by Prof. Des Tobin to investigate pigment cell (melanocyte) biology in health and disease, and the particular focus of this project will be on how human skin pigment cells become unstable to potential result in melanoma formation. Melanoma exacts a very heavy societal toll, given its aggressive, often lethal course, and its rising incidence. Despite very considerable global research efforts, long-term survival rates have improved only modestly despite new and very costly drugs (e.g., immune checkpoint inhibitors).
In the midst of voluminous melanoma research data, this project takes a step back to reassess fundamental variability in the molecular stability of melanocytes in different human skin anatomic compartments (incl. skin epidermis and hair follicle). We also aim to identify pathways to induce apoptosis in pigment cells including neoplastic pigment cells (e.g., melanoma), by gaining much-needed new insights into how precursors of pigment cell neoplasms (incl. melanoma) become unstable. We will utilise Caucasian skin samples from Ireland and Britain, as melanoma can exhibit demography-specific traits (e.g., mutation signatures in Irish and British patients can differ from those in other populations). Specifically, this position aims to gain understanding of melanocyte to melanoma homeostasis in human skin, rather than in more commonplace rodent/fish melanoma models.
Candidates will have excellent current knowledge of the literature in the field, especially as pertains to the human skin pigmentary system; maintain accurate and comprehensive experimental records with excellent attention to detail; assist in preparing presentations and reports as required; maintain laboratory equipment and facilities, and other duties associated with the research project, of an occasional nature, which may be assigned by the Principal Investigator, Prof. Des Tobin
PD1 Salary: €37,874 - €43,782 per annum
PD2 Salary: €45,041 - €49,049 per annum
Closing date: 17:00hrs (local Irish time) on 3 August 2020.
Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.
Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/
UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.
Informal Enquiries ONLY to:
Prof Desmond Tobin
Professor of Dermatological Science
Email address: [email protected]