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Discovery and characterisation of ER-phagy protein networks

Postdoctoral Research Fellow
Centre for Cancer Research
£33,797 – £40,322 fixed term for 36 months
The Wilkinson laboratory seeks a Postdoctoral Research Fellow. This Cancer Research UK-funded post is available from May 2020 for an initial term of three years (salary of £33,797-£40,322, dependent upon experience).
Discovery and characterisation of ER-phagy protein networks
Selective autophagy of the endoplasmic reticulum (ER-phagy) is emerging as a fundamental pathway in maintenance of cellular health. Furthermore, our laboratory has identified aberrations in ER-phagy during formation and progression of cancer. However, our view of the molecular composition and function(s) of the ER-phagy pathway is incomplete, especially in physiologically relevant settings.
To rectify this, the successful applicant will identify novel ER-phagy molecules in cell and organoid models from pancreatic and gastric origins. This will be done using state-of-the art proximity proteomics approaches. The applicant will also screen identified molecules for function in ER-phagy/autophagy, alongside select candidates already uncovered by the laboratory. Techniques here will include cellular genetic approaches such as CRISPR/Cas9. Additional cell biological techniques, including confocal microscopy and ER organellar proteomics, will be used to probe ER functional regulation by the identified molecules, and to determine how this impacts upon cellular state.
Overall, the work will contribute to a larger, high-quality program of research designed to address the mechanisms and functions of ER-phagy, hosted within a dynamic laboratory at the forefront of this field.
Ref: 051393. Closing date: 11 March 2020
For further particulars and to submit an application visit our website www.vacancies.ed.ac.uk

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