Postdoctoral researcher in gene regulation

Regulatory elements that turn genes ON or OFF are promiscuous and can act over large genomic distances.

How do regulatory elements find their specific target genes?

We address this problem by studying protein factors that fold chromosomes to impact the arrangement of regulatory elements and gene promoters in 3D nuclear space. We genetically engineer Drosophila melanogaster to study the biological relevance of these factors and how they impact gene transcription. We also perform parallel experiments in mammalian tissue culture cells to contrast and compare with our results in Drosophila.

We use multidisciplinary approaches including genetics (genome-engineering), genomics (RNA-seq, ChIP-seq, chromosome conformation capture, genome-wide screens), biochemistry (proteomics, structural biology), and live-imaging.

We are looking for a motivated and capable member to join our international team to work on a competitive project. Experience in genomics is prioritized.