We are seeking an enthusiastic, highly motivated post-doctoral scientist with a strong interest in RNA biology for a 3 year position in the group of Dr Berndt Müller and Dr Jonathan Pettitt at the Institute of Medical Sciences of the University of Aberdeen (
www.aberdeenwormlab.org). The researcher will work as part of a BBSRC-funded research program that aims to understand the molecular machinery critical for an essential, nematode-specific pre-mRNA maturation step termed spliced leader trans-splicing. This research will inform therapeutic strategies to fight parasitic nematodes that pose significant threats to human and animal health. The project combines state-of-the-art nematode molecular genetics and RNA biochemistry, including genome editing, proteomics and RNA sequencing technologies to (1) determine the molecular composition of RNA-protein complexes critical for spliced leader trans-splicing; and (2) define the roles of newly identified protein factors. We have partnered with Prof Michael Sattler (Technical University of Munich), a leading expert in the structural biology of RNA-protein complexes, for the detailed analysis of molecular interactions and structures. This comprehensive, multifaceted approach will provide crucial insights into nematode gene expression, with clear implications for the development of new treatments for parasitic nematode infections.
Candidates should have a PhD in a relevant biological discipline such as Molecular Biology, Biochemistry or Genetics, with experience of working with Caenorhabditis elegans or another genetically-tractable system, and a strong interest in RNA biology.
Candidates are expected to have extensive experience in molecular biology techniques, RNA analysis and the investigation of RNA-protein and protein-protein interactions. Experience with high-throughput sequencing, proteomics, confocal fluorescence microscopy or genome editing is an advantage.
Informal enquires about the project and the position are strongly encouraged and can be directed to Berndt Müller (
[email protected]).
Salary will be at the appropriate point on the Grade 6 salary scale (£33,797 - £36,914 per annum).
Should you require a visa to undertake paid employment in the UK you will be required to fulfil the minimum points criteria to be granted a Certificate of Sponsorship and Tier 2 visa. As appropriate, at the time an offer of appointment is made you will be asked to demonstrate that you fulfil the criteria in respect of financial maintenance and competency in English. Please do not hesitate to contact Grant Rae, HR Adviser on +44 (0)1224 437068 or email
[email protected] for further information.
The closing date for receipt of applications is 08 November 2019
Should you wish to make an informal enquiry please contact:
Dr Berndt Müller
+44(0)1224 437536
[email protected]Please do not send application forms or CVs to Dr Muller.
Please quote reference number IMS174R on all correspondence
The School of Medicine, Medical Sciences and Nutrition welcomes a diverse working environment and recognises the benefits this can bring. The School is keen to receive applications from individuals from across all of the equality protected characteristics (race, gender, disability, gender reassignment, age, sexual orientation, religion/belief, pregnancy/maternity, marriage/civil partnership).
