UCD Post-doctoral Research Fellow Level 2 REF 011714
School of Medicine, University College Dublin
"Reactive oxygen species disruption of bacterial tyrosine phosphorylation alters the functional ecology of the intestinal microbiome in inflammatory bowel disease"
This project will examine the effect of reactive oxygen species on individual constituents of the faecal microflora. The successful candidate will lead a three year project that aims to isolate, identify and characterise the effects of excess reactive oxygen species on individual core microbial constituents of intestinal samples from children with inflammatory bowel disease. This is an advanced research focused role, building on your prior experience as a post-doctoral fellow, where you will conduct a specified programme of research supported by research training under the supervision and direction of a Principal Investigator.
The primary purpose of the role is to develop new or advanced research skills and competences, on the processes of publication in peer-reviewed academic publications and scholarly dissemination, the development of funding proposals, and the supervision and mentorship of graduate students along with the opportunity to develop your skills in research led teaching.
In addition to the Principal Duties and Responsibilities listed below, the successful candidate will also carry out the following duties specific to this project:
• Isolate and identify, using flow cytometry, tyrosine phosphorylation patterns of individual members of fecal microflora
• Compare tyrosine phosphorylation patterns between microflora from normal children, those with active inflammatory bowel disease (IBD) and those with IBD in medical remission
• Determine the phosphoproteomes of dominent members of the fecal microflora and how they are altered on exposure to reactive oxygen species