Professor Richard Houlston FRS and Dr Martin Kaiser are currently recruiting two Myeloma UK funded Research Fellows (Postdoctoral) to work on projects aiming to gain new insights into the inherited and acquired sequence changes influencing the development of the immune plasma cell cancer multiple myeloma. We are looking for highly motivated Research Fellows with an interest in human cancer and in generation of large-scale omics data and gene-editing screens. We wish to appoint an individual with extensive experience of molecular genetics, relevant to disease gene characterisation. We undertake a broad range of genetic experiments including high-throughput sequencing, epigenetic profiling and Hi-C analyses, MPRA and CRISPR.
The successful candidate will join a vibrant research group on the identification and characterisation of cancer genes. We work on haematological cancers but also have on-going projects on other tumours. The recent publications, illustrating the scope of our work - Nat Genet 2018;50:1375; Blood Adv 2019;3:21; Nat Commun 2015;6:6178. Cancer Res. 2019 Feb 1. pii: canres.2888.2018. Nat Genet. 2017;49:789.
We implement multiple different molecular strategies to translate genetics to tumour biology including high-throughput sequencing, epigenetic profiling and Hi-C analyses, MPRA and CRISPR. There is strong bioinformatics/statistical support within the group.
The post holder would be expected to bring genetic research experience to development of experimental design and implementation of projects and will be expected to interact with, and supervise, junior team members, together with other senior researchers.
Informal enquiries about on-going projects can be made to Richard Houlston ([email protected]
) or Martin Kaiser ([email protected]
). Please Note - these emails are for enquiries only; formal applications must be submitted online.