• Salary within the range of £31,604 - £41,929 per annum (dependent upon qualifications and experience)
• Job Ref: MI/18/104_4
• Duration: Fixed term for 3 years
About the role:
We are looking for a highly-motivated Postdoctoral Scientist to join Dr Baena’s Prostate Oncobiology group to study the role of inflammation on prostate tumour initiation and how to prevent their progression to metastatic prostate cancer.
Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men worldwide, accounting for 15% of all male cancer deaths. PCa patients exhibit a high heterogeneity both clinically and biologically highly variable clinical behaviour; some have indolent disease whilst in others it is lethal. Although the initial response to androgen deprivation therapy is almost universal, progression to castration resistant state is inevitable and lethal.
Previous work from our laboratory shows the importance of detailed understanding cellular and molecular events leading to castration-resistant prostate cancer as they’re key for the development of improved therapies for such patients (Barros-Silva et al., 2018; Parry et al., 2019; Baena et al., 2013).
The initiation and maintenance of tumour cells rely largely on their ability to interact with and adapt to changes in their primary and metastatic microenvironments. Therefore, the post holder will work on defining how tumour-stem cell promote castration-resistant stage by modifying its local microenvironment. This study will provide new avenues to prevent prostate tumour progression and metastasis by coupling anti-tumour and anti-microenvironment (i.e. immune) interventions for prostate cancer patients.
You will have a PhD in a relevant related subject and have research laboratory experience. You will also have profound knowledge in cellular and molecular biology and have experience of working with in vivo cancer models. You will have significant experience of cell culture, particularly in vitro 3D culture systems and handling primary cells. Profound experience in FACS analyses and lineage tracing work is also essential for this position.
This is an exciting opportunity for you to be involved in developing and driving the project as well as writing up work for presentation and publication.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk
), an Institute of The University of Manchester (www.manchester.ac.uk
), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org
), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.
We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk
), one of the largest cancer treatment centres in Europe.
The CRUK Manchester Institute is a key part of the Belfast-Manchester Movember Centre of Excellence for Prostate Cancer. As well as bringing together expert researchers and clinicians, the Movember Centres of Excellence will also provide a world-class training ground for the scientists of the future, building a legacy of top prostate cancer researchers in the UK, as well as establishing international collaborations for the brightest minds to tackle the most important questions in prostate cancer research – now and into the future.
How to apply?
To apply for this position please visit our website: https://www.cruk.manchester.ac.uk/recruitment/candidate/searchvacancies
For any informal enquiries about this post, please contact Dr Esther Baena, email: [email protected]
The deadline for receipt of applications is: Thursday 05 September 2019.