Department/Location: MRC Mitochondrial Biology Unit
The University of Cambridge wishes to appoint a Postdoctoral scientist to join the research group of Dr Edmund Kunji in the MRC Mitochondrial Biology Unit of the University of Cambridge.
The postholder will work within a programme focussed on mitochondrial transporters. Transport processes are crucial for the functioning of mitochondria and mutations in transport proteins cause of a wide range of metabolic, neuromuscular and developmental diseases. Basic molecular understanding of their structure and mechanism is required to understand their role in health and disease.
The goal of the project is to study their structures in different conformational states by electron cryo-microscopy and/or x-ray crystallography. The post-holder will participate in every stage of the process, from the generation of expression strains or cell lines, isolation of mitochondria, purification and sample preparation, data acquisition and processing, and structure model building and interpretation. There will also be an opportunity to study their role and mechanism using a wide range of biochemical and biophysical techniques. This project is part of a collaborative SNF Sinergia grant together with Profs. Hediger and Lochner of the University of Bern.
Candidates will have a PhD in Structural Biology/Biophysics or related disciplines, and a track record of research achievements. Knowledge of protein purification and experience in structural biology are essential.
The MRC Mitochondrial Biology Unit is a world-renowned centre for mitochondrial research. Additional information can be found at http://www.mrc-mbu.cam.ac.uk/
Fixed-term: The funds for this post are available for 3 years in the first instance.
To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/21519/
The closing date for applications is Wednesday 12th June 2019 with interview date yet to be confirmed.
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.
Please quote reference SM19126 on your application and in any correspondence about this vacancy.
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