Research Fellow - Pathology

DEPARTMENT OF PATHOLOGY
DUNEDIN SCHOOL OF MEDICINE


Who we are:


The Developmental Genetics & Pathology laboratory team is focused on aberrant developmental mechanisms of disease, particularly cancer. The team comprises four research fellows, two assistant research fellows (including a bioinformatician), five postgraduate students, and an intern, housed within a well-equipped research laboratory, and using state-of-the art advanced methodologies. The research team has a well-established international profile.


The Role:


As a Research Fellow based within our department you will be part of the team working on the project ‘Epigenomic profiling to predict patient response to melanoma immunotherapy’.


Some key tasks include:
• Collecting samples for discovery cohorts.
• Carrying out sequencing-based analysis of genome-wide methylation landscapes of responding and non-responding patients.
• Investigating mutational profiles of responding and non-responding patients.
• Developing Sequenom assays for methylation biomarkers identified in responding and non-responding patients.
• Carrying out gene expression analysis of biomarker regions of interest in the validation cohort.
• Contributing to the development and dissemination of research tools for genome-wide and epigenome-wide analysis for the Eccles laboratory group, including for CancerHub.


Your Skills and Experience:


• PhD in relevant field.
• Experience in identifying blood-based biomarkers.
• Experience with epigenetic analysis and large-scale/integrated bioinformatic analysis.
• Organised, methodical, with excellent attention to detail.
• Ability to work as a team member and to interact well with a range of staff and health professionals, and to perform tasks with minimal supervision.


Further Details: Position 1901102


This is a full-time, fixed term position for four years and is available immediately.


Specific enquiries may be directed to Professor Michael Eccles, via the contact details attached.