A 3-year postdoctoral position is available at the Institute of Clinical Sciences (ICS) at Imperial College to work in the Host-Microbe Co-metabolism Group headed by Dr Filipe Cabreiro. We are located on the Hammersmith Hospital Campus in West London (W12). The institute has first-class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the excellence of Imperial College.
We are looking for an enthusiastic, creative postdoctoral scientist to join a diverse research team that works at the intersection of organismal biology, metabolism, pharmacology and the Microbiota. Recent technologies and questions we have tackled include:
• We have developed a 3-way Host-microbe-Drug and a 4-way Host-Microbe drug-nutrient (Pryor et al., in Revision Cell) screening approach to investigate how drugs and nutrients impact host health.
• What are the metabolic pathways in bacteria that mediate the efficacy of fluoropyrimidine cancer therapy (Scott et al., 2017 Cell)?
• How does the anti-diabetic drug metformin metabolically rewire E. coli to increase host lifespan (Cabreiro et al, Cell 2013).
• How does the genetic landscape of an organism influence interventions for lifespan extension (Burnett, Valentini, Cabreiro et al, Nature 2011)?
The ideal candidate will aim to make a major contribution to our ongoing research program and, in addition, develop and carry out his/her own line of research within the group’s areas of interest and expertise. Currently, we are positively obsessed with how the microbiome develops resistance to host targeted drugs such as metformin and how this phenomenon regulates host health and disease.
Candidates must have a strong publication record (or manuscripts in revision at high-impact journals), excellent verbal and written communication skills, and a track record of addressing scientific problems in an innovative, creative, thoughtful and systematic manner. Candidates with an experimental background should have substantive experience in molecular techniques. Candidates should be proficient in handling mice and/or C. elegans as a model organism. Candidates keen to mix wet and dry lab computational work are particularly encouraged to apply. Whatever your background, a keen interest in metabolism and the role of the microbiota is a must.
Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £34,397- £37,486 p.a.
To apply, please visit:
https://www.imperial.ac.uk/jobs/ For technical issues when applying online please email
[email protected] Closing date: 6 June 2019
Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see
https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research- evaluation/
The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.
http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/
