The Heidelberg University Hospital is one of the most important medical centers in Germany and stands for the development of innovative diagnostics and therapies as well as their rapid implementation for the patient. With approximately 10,000 employees in more than 50 clinical specialist departments with approximately 1,900 beds, around 66,000 patients are treated on an intpatient basis or 1,000,000 times on an outpatient basis.
The work in our research group focuses on stem cells and therapy resistance. We aim to understand how epigenetic dysregulation participates in the pathogenesis and chemo-resistance of AML. To follow this question, a broad number of in-vitro- and in-vivo-models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse. The current position is funded by a new project grant from the DFG (Deutsche Forschungsgemeinschaft).
Related Publications:
Göllner, S. et al.: Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia (AML). Nature Medicine 2017 Jan; 23(1): 69 – 78.
Zhou, F. et al.: AML1-ETO requires enhanced C/D box snoRNA formation to induce self-renewal and leukemia. Nature Cell Biology, April 2017.
The position is limited to 2 years with the option of further extension.
Tasks
• Identify genetic networks in the regulation of human leukemia stem cell activity
• Understand the mechanisms of developing and overcoming therapy resistance
Required Qualifications
• PhD in Biology, Biochemistry or equivalent
• Broad expertise in basic cell- molecular and biochemical techniques (western blotting, immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
• Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques
• Experience and high motivation to work with mice and primary patient cells
• Driving independently the experimental and project designs
• Rapid understanding and independent analysis of complex data
• Experience in writing scientific reports and papers
• Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, Lightroom, GraphPadPrism, R, BLAST)
• Strong communication skills (oral presentations and writing)
• Fluent English and German, both in written and spoken
We offer
• Groundbreaking innovative projects within the field of leukemia research
• A highly dedicated, diverse and international team with access to on-site mouse facilities, sequence facilities and unique leukemia samples
• Access to state-of-the-art equipment
• An exciting and highly translational research field
• Presentation and publication of the data at international scientific meetings and in journals
• Collaboration with many experimentally or theoretically oriented labs and groups in the university hospital, in the Heidelberg area (e.g. DKFZ, EMBL, NCT) and with international research partners of other organizations abroad
Contact & Application
Applications should be submitted online as one single PDF-file (max 5 MB).
Please do not send original documents by mail services, since they will not be returned.
Please include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2 – 3 references. For further information, you may contact: Annette Becker, M. A., Science coordinator, phone +49(0) 6221-56-8552.
University Hospital Heidelberg
Internal Medicine V
Department of Hematology, Oncology, Rheumatology
Annette Becker
Im Neuenheimer Feld 410
69120 Heidelberg, Germany
phone +49(0) 6221-56-8552
[email protected] The University Hospital Heidelberg offers
• individual, target-oriented advanced training • ticket for public transport • nursery and kindergarten as well as holiday organization for schoolchildren • health promotion• university sports / library
www.klinikum.uni-heidelberg.de/Jobs-KarriereWe stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.
