MRC Postdoctoral Research Scientist – LMS 905
Computational Regulatory Genomics – Long-range transcriptional regulation
Fixed Term, 3 years
£35,340 - £38,181 pa inclusive*
London, UK
A 3 year postdoctoral is available at the MRC London Institute of Medical Sciences (LMS) and Imperial College London to work in the Computational Regulatory Genomics group headed by Professor Boris Lenhard. The group studies gene regulation at the genome-wide level using methods of computational genomics and epigenomics. The group is now also applying experimental techniques of regulatory genomics, and has developed the first low-input cap analysis of gene expression methodology to allow mapping promoters and enhancers from as little as 1000 cells. The interests of the group range from investigating sequence signals and chromatin organisation at core promoter regions to revealing rules of communication between core promoter and distal regulatory elements and how they give rise to elaborate spatiotemporal expression patterns in development. The group has a track record of excellence and innovation in computational genomics, with numerous publications in top-tier journals and extensive international collaboration (for further information please visit
https://lms.mrc.ac.uk/research-group/computational-regulatory-genomics/ ).
We are looking for an enthusiastic, creative, ambitious and skilled postdoctoral scientists with background in biological sequence analysis, comparative genomics and/or analysis of next-generation sequencing-based experiments. You will need a PhD (or equivalent) in a relevant subject. A competitive publication record in the field is expected, as well as knowledge of molecular biology and evidence of proficiency in the computational analysis of biological data or the development of computational tools for given purpose. Proficiency in bioinformatics programming is required. The post is open for candidates wishing to pursue a career in computational genomics in collaboration with experimental researchers, and to candidates who wish to combine experimental and computational approaches in their own work. For candidates wishing to combine experimental and computational techniques, we are looking for expertise in experimental genomic techniques.
The project will broadly focus on studying long-range transcriptional regulation and promoter-enhancer interactions in Metazoan genomes. Its aims will be to understand how genes interact with their regulatory elements at long distances, how long-range regulatory elements evolve and/or how they are affected by extracellular signals during development and differentiation. The research is expected to be based on novel approaches for the analysis of original and published comparative genomic, epigenomic, transcription factor binding and chromatin conformation experimental to investigate long-range regulation at genome-wide level.
The post supports post-doctoral scientists in early or changed career training and helps establish them as successful research scientists in their chosen field. It comes with funding for computing, consumables, training courses and travel.
LMS is an institute funded by MRC and is a division of the Faculty of Medicine at Imperial College London. Based on the Hammersmith Hospital Campus in West London, the LMS has first class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the established clinical base of Imperial College. For more information, visit
www.lms.mrc.ac.uk.
Informal enquiries should be sent to
[email protected] For full details of this post visit
https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/1018 and upload your CV and research statement not longer than two pages, submitted as a separate document. The research statement should outline your most important achievements to date and a brief vision of your present research interests and future career.
The MRC London Institute of Medical Sciences is a research institute within UK Research and
Innovation. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at
www.ukri.org Closing date for all completed applications is 13 September 2018
*Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.