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Postdoctoral Research Associate

Haematopoiesis is the process of blood-cell production through proliferation, self-renewal and differentiation of haematopoietic stem cells (HSCs). An indispensable element for the interaction between stem cells and their niche is the adhesion molecule a4-integrin (Itga4). Our research focusses on the role of Itga4 in haematopoietic diseases. We have recently shown that in hosts transplanted with fluorescently-labelled Itga4-deficient or wildtype HSCs we could quantitate the differences in the relative contribution of the two donor populations to the output of blood-cells. Our results demonstrate a strong advantage for wildtype HSCs over Itga4-null mutants. To better understand the effect of Itga4 on key haematopoietic parameters requires the development of dynamical mathematical models. This project will integrate mathematical modelling with experimental studies to generate new ideas and hypotheses for a deeper understanding of HSCs and their role in haematopoietic diseases. In addition, it will expand our knowledge of the process and mechanisms of stem-cell transplantation which can lead to further translational studies.
The successful candidate will develop dynamical mathematical models of the haematopoietic system and use these to test hypotheses of the role of Itga4 on HSC fate and to infer key haematopoietic parameters that will inform further experimental studies.
You must have a PhD (a PhD to be obtained soon) with a strong mathematical modelling component, preferably related to biological systems, and some experience of scientific programming is highly desirable.
This post is full time and fixed term for 12 months. The post is available from March 2018.
Closing Date: Wednesday 7th February 2018 at 5pm (GMT)

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