We are looking for a highly motivated candidate with a strong background in data analysis, statistics and in programming in R and/or Python, and an extensive experience in NGS data analysis (RNA-seq, ChIP-seq,WES). In addition, the candidate should able to run comparative marker, GSEA, ssGSEA, EdgeR/RIGER, and ICA analyses, be familiar with the use of cBioPortal or MSigDB datasets, and be able to implement their data on GENE-E/Morpheus and IGV softwares. Applicants should hold a PhD degree in Computational Sciences or related disciplines (or have recently submitted their thesis with scheduled defense).
The computational biologist position will be opened in March 2018 for three years (renewed each year) in the laboratory of research on molecular basis of Acute Myeloid Leukemia headed by anERC / ATIP-AVENIR team leader Dr. Alexandre PUISSANT (
https://thepuissantlab.jimdo.com/ ).
The Puissant laboratory deciphers molecular mechanisms involved in leukemia development in pre-clinical mouse models of AML. Unbiased in vivo screening approaches are deployed in order to provide new therapeutic strategies to treatAML.Large-scale shRNA screening, genetic, biochemical, cell biological, as well as genome-wide approaches (WES, RNA-Seq, ChIP-Seq) are currently used in this lab.
THE TEAM:
The Puissant laboratory is housed at the Jean Bernard Center (INSERM U944) which is located at the Saint-Louis Hospital campus in Paris, France . The research developed in this institute encompasses a broad spectrum of fields, including cancer genomics, cancer biology and leukemia research. Most studies carried out in the unit have implications in translational research, together with clinical groups of the Saint-Louis Hospital. Our laboratory benefits from a direct access to the core facilities including: a recently extended animal facility, a sequencing facility (Mi-seq, Hi-seq, and Next gen-seq technologies), and a flow core facility.
HOW TO APPLY:
Thanks to send your application (in French or English) to alexandre.puissant(at)inserm.fr before February 1st 2018 , by including in one single pdf file (applicantName_application2018.pdf):
- description of the main past achievements and skills of the candidate (max 2 pages);
- full Curriculum Vitae;
- contact details of three individuals who can be contacted for recommendation letters.
