A Postdoctoral Training Fellow position in molecular medicine is available to play a key role in facilitating the research of the Systems and Precision Cancer Medicine Team (Team Leader Anguraj Sadanandam). Our interdisciplinary lab focuses on personalized medicine and companion diagnostics using cancer subtypes and evolution by integrating multi-omics (molecular and metabolism) and phenomics (phenotypes) data. We perform this by integrating wet-lab science with computational biology skills by cross-comparing and integrating high-throughput data (including whole tumour and single cell omics data and cross-species analysis) between patients and in vivo and in vitro models. To this end, we have classified different tumor types including breast cancer cell lines, and pancreatic and colorectal tumours and cell lines into distinct molecular and/or drug response subtypes (PNAS 2012, Nature Medicine 2011, 2013 and 2015, and Cancer Discovery 2015). For more information please visit:
http://www.icr.ac.uk/our-research/researchers-and-teams/dr-anguraj-sadanandam and
http://www.icr.ac.uk/news-archive/scientists-uncover-four-different-types-of-bowel-cancer You will help us in characterize biomarkers identified in pancreatic, colorectal or breast cancers primarily using patient samples and in vivo and in vitro models. You will also be involved in testing subtype-specific therapies using pre-clinical trials. You will enjoy working in the interdisciplinary fields and collaborating with our internal and external collaborators.
Your responsibilities will include day-to-day laboratory operations such as cell culture, different molecular biology and biochemical techniques (including, but not limited to DNA, RNA and protein isolation, isolation, RT-PCR, Western blots, immunohistochemistry, flow cytometry, and in vitro and in vivo experiments and interpretation of the results.
In addition, you will work closely with the team and other collaborators to develop and validate hypothesis that will arise out of the high-throughput omics data including genomics and metabolomics.
The successful applicant will hold a PhD in molecular medicine or cancer biology and have experience in in vivo (patient-derived/cell-derived xenograft) models performing pre-clinical trials in cancer. Experience in handling patient tumour tissues, laboratory management, molecular biology and biochemical techniques, cell culture and in vivo experiments is essential as well as excellent organizational, scientific writing and communication skills. Experience in statistical data analysis and computational biology/bioinformatics would be advantageous.
This is an excellent opportunity for an independent and motivated individual to work in an exciting and highly collaborative environment.
The position is offered on a fixed term 1 year contract. The full salary scale for this post is in the range from £30,410 to £43,463 p.a. inclusive. Starting salary will be based on postdoctoral experience. The position will be based in Sutton.
Informal enquiries can be made to Dr Anguraj Sadanandam (
[email protected]). Please DO NOT send your application to Dr. Sadanandam, formal applications must be submitted online.
To apply please upload your CV and covering letter (addressing where you meet the person specification and incl. the names and addresses of two referees) online.
