Anaplastic Thyroid Cancer Post Doctoral Position
Oncology, University of Western Ontario
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7239
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Deadline:
28 May 2017
(application date has expired)
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£36,000 to £43,000 depending on experience and
qualifications (note salary is in Canadian funds not
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Contact:
Anthony Nichols
PI Dr. Anthony Nichols, along with cancer bioinformaticist Dr. Paul Boutros are leading a multi-institutional collaboration to study a rare, but nearly universally fatal type of undifferentiated thyroid cancer called anaplastic thyroid cancer (ATC). We have sequenced 180 of these rare tumors and multiple high impact manuscripts are in progress.
Up to 80% of the time these cancers arise from well-differentiated, typically indolent thyroid cancers. Through sequencing of both the well differentiated and undifferentiated thyroid cancer components, we have identified shared variants, which proves a common genetic origin. More interestingly, there were additional mutations seen exclusively in the undifferentiated components of the tumors, a subset of which we speculate are critical to thyroid cancer progression. However, these variants require functional validation.
An ambitious, hardworking Post-Doc is sought to carry our this functional validation using CRISPR/Cas9, siRNA and overexpression studies to altered well differentiated thyroid cancer cell lines and xenograft models to induce differentiation into an ATC phenotype. This project has the potential to provide profound insights into the progression of thyroid cancer. High impact publications are anticipated.
