Research Fellow (103618-1224)

    • Application Deadline
      Deadline:
      02 February 2025
      (application date has expired)
    • Job Salary
      £34,866 to £45,163 £34,866 to £45,163 per annum
    • Website
    • Contact Name
      Contact:
      Bruno Frenguelli


    Location: University of Warwick Campus,Coventry
    Department: School of Life Sciences
    Position Type: Fixed Term 20 months
    Duration: 20 months from start date
    Salary: £34,866 to £45,163 per annum
    Hours: 36.5 per week

    About the Role
    Flexible start date March 2025

    Stroke Association; Novel approaches for the treatment of ischaemic stroke

    What scientific question will you investigate?  / Outline of the project aims
    An exciting opportunity is available to study a novel approach to the treatment of ischaemic stroke. Stroke deprives the brain of the substrates necessary to synthesise ATP, the cellular energy source. As a result, ATP levels decrease in the ischaemic brain initiating the pathological cascade that results in neuronal death. Moreover, the metabolites of ATP, such as adenosine, are lost from the brain into the circulation where they are no longer available for resynthesis into ATP. This prolongs the ATP deficit, worsening outcome, even after, and if, the blood supply to the brain is restored. We have pioneered an innovative approach to this brain bioenergetic crisis through providing the brain with ribose and adenine, two vital precursors of ATP, which the brain converts into ATP. Extensive in vitro validation and encouraging confirmatory results in an in vivo stroke model resulted in a project grant award from the Stroke Association to pursue ribose and adenine (RibAde) as a potential hyperacute point-of-care treatment for stroke, that could not only metabolically support the ischaemic brain, but may also increase chances for successful recanalization therapy.

    The successful applicant will have a PhD or equivalent in neuroscience or a related discipline, will be familiar with the scientific literature pertaining to cerebral ischaemia and brain injury, and will have extensive experimental expertise in animal models of ischemic stroke.

    You should either currently hold UK Home Office Personal License PILA-C or should be willing to undertake the course and hold this license prior to starting this role.

    About the research group
    The Frenguelli lab has a long track record of studying the release, role and replenishment of the purine molecules adenosine and ATP in the mammalian brain. Through these studies the lab has arrived at a potential treatment for stroke that will be tested in this project.

    The Frenguelli lab is part of the Neuroscience Research Cluster in the School of Life Sciences at Warwick University. We are a diverse group of neuroscientists who study a variety of physiological and pathological process occurring in the nervous system. Through in silico, molecular, cellular and whole animal approaches, we investigate fundamental properties of synaptic transmission and plasticity, the influence of pathogenic proteins, and the impact and mechanisms of stress, pain and epilepsy.

    The Frenguelli lab is located in the Interdisciplinary Biomedical Research Building (IBRB), a new £54m state-of-the-art research facility that combines cutting edge research infrastructure with award-winning architecture.

    Any requests for further information about the role can be directed to Bruno Frenguelli; [email protected]

    We and the wider University of Warwick environment offer substantial opportunities for professional development including regular opportunities to present research finding at internal, local, national and international conferences.

    About You
    We are looking for someone with expertise in experimental models of ischemic stroke, in particular filament occlusion of the MCA. Given the time-limited nature of the position, such expertise is a necessary requirement, as is expertise in post-stroke functional assessment. Applicants should therefore be proficient in filament occlusion models, surgical techniques and post-surgical behavioural monitoring.

    You should either currently hold a UK Home Office Personal License PILA-C or should be willing to undertake the course and obtain this license through online courses, ideally prior to starting this role.

    If you are near submission or have recently submitted your PhD but have not yet had it conferred, any offers of employment will be made as Research Assistant at the top of level 5 of the University grade structure. Upon receipt of evidence of the successful award of your PhD, you will be promoted to Research Fellow on the first point of level 6 of the University grade structure.

    About the Department
    School of Life Sciences

    For further information about the School of Life Sciences please see via our website.

    We believe that collegiality, openness, inclusivity and diversity are essential for an excellent environment; this ethic has enabled us to gain an Athena SWAN Silver award. We are dedicated to building a diverse and inclusive workplace, so if you are excited by this role, we encourage you to apply, even if your past experience does not match exactly. We also encourage applications from all groups with protected characteristics.

    About the University
    Born in the 60s with a mindset of boldness, imagination and collaboration, the University of Warwick is a world-leading research-intensive university with the highest academic and research standards. We’re one of the world’s top universities, ranked 67th in the world and 10th in the UK*, with 92% of our research assessed to be ‘world leading or internationally excellent’**.

    You'll be joining a diverse, innovative and globally connected community committed to igniting real world progress. Here at Warwick, we offer you opportunities to follow your ambitions as long as you bring the energy and determination to succeed.

    *QS World University Rankings 2024

    ** Research Excellence Framework 2021

    To find out more about us visit our website.

    How to Apply
    Closing date: 2 February 2025 at 11.55pm.
    Interview date: TBC
    Start date: Flexible

    To apply, please click ‘Apply’ below and follow the how to apply section.

    Find our benefits and commitment to inclusion via the apply button.


    PostDoc Jobs
    Search for PostDocs
    Advertise a PostDoc Jobs
    PostDoc Advice Forum

    FindAPostDoc. Copyright 2005-2025
    All rights reserved.