Recently established research team studying signal pathways during the invasion of the Babesia parasite to the host cell offers a postdoc position.
Research description: Functional Analysis of Babesia Calcium-Dependent Protein Kinases
Babesia is a tick-transmitted parasite infecting a variety of animals including humans. Central to Babesia pathogenesis is parasitism inside host erythrocytes – an ability shared with its apicomplexan relative Plasmodium, the causative agent of malaria. Invasion to host cells and subsequent intracellular multiplication of these parasites are orchestrated by a wide repertoire of molecules including the calcium-dependent protein kinases (CDPKs). Our research is targeted to the unbiased screen of yet unrevealed Babesia divergens CDPKs and their association with fundamental biological processes using a newly established platform of transgenic techniques. Comprehensive biochemical and functional characterization of intraerythrocytic BdCDPK isoenzymes will be accompanied by their targeted inhibition using a library of Bumped Kinase Inhibitors (BKIs) to evaluate BdCDPKs as potential drug targets.
Requirements:
interest in an academic career
PhD degree in biology or chemistry
analytical skills, independence and motivation
excellent communication skills and sense of responsibility
previsous laboratory experience and knowledge of basic methods of parasitology and molecular biology
active knowledge of English
knowledge of the principles of genome editing and microscopic techniques is an advantage
What do we offer :
attractive research combining parasitology and molecular biology
full time position for 18 months
possibility of further education according to the individual motivation
regular participation in foreign conferences
possibility of internships abroad in cooperating laboratories
5 weeks of holidays, discounted mobile and banking services, MS Office for personal use, language courses
Start date: August/September 2023 or upon agreement
Please submit your structured CV and cover letter via e-mail to
[email protected] by June 30th 2023.
For more information, please visit:
www.prf.jcu.cz .
