An exciting opportunity for a postdoc to join Dr Barney Bryson’s research group to work on a highly translational project, which represents the latest phase in the teams’ ongoing efforts to develop a novel therapeutic strategy to overcome paralysis in motor neuron disease (MND), using a combination of stem cell derived neural replacement, optogenetics and sophisticated stimulation devices.
The post-holder will be integrally involved in the pre-clinical evaluation of a prototype cell therapy product, along with a custom-designed implantable stimulation/recording device, in a rodent model of muscle paralysis, which will pave the way for translational implementation of the long-term therapeutic strategy. The postholder will assist with human iPSC cultures, including maintenance and motor neuron differentiation as well as characterization assays. In addition, you will also carry out surgical engraftment of the prototype cell therapy in rodents, along with behavioural, physiological and histological analysis to determine essential experimental outcome measures.
Key Requirements
The postholder must have a PhD in a relevant discipline (e.g., neuroscience, bioscience, or a similar field), excellent interpersonal and communication skills, and strong problem-solving abilities. Experience in human iPSC-derived neuron culture, microsurgical techniques in rodents, histology and confocal/multiphoton imaging would be a significant advantage.
Please apply via UCL's vacancies page -
https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs - and in the search function, type in the following reference number - B02-00229
