The Rosalind Franklin Institute (The Franklin) is a National Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology. The Biological Mass Spectrometry Theme focuses on the development of new instrumentation for mass spectrometric imaging (MSI) allowing the visualisation of molecular distributions at subcellular level and the de-novo structure elucidation of chemical species detected by MSI techniques. The ultimate goal of the Theme is to understand the working mechanism of molecular interaction networks in health and disease and define novel diagnostic and prognostic targets for next generation healthcare.
The project focuses on the development of new mass spectrometric imaging instrumentation from ion source technology through mass spectrometric analysers to new workflows for data analysis and interpretation. The new ionisation modalities including laser desorption methods and secondary ion mass spectrometry employing multiply charged cluster projectiles will enable spatial resolutions required for true single cell resolution. The postholder will be expected to work on biological aspects of the development and demonstration of cellular resolution MS imaging, including culturing cells and organoids and preparing both animal and human tissues for analysis. The work includes alternative modalities of imaging, for example histological imaging, immunofluorescence, confocal microscopy, imaging mass cytometry and single cell transcriptomics. While the post holder is not expected to participate in instrument building, good technical skills are desirable for using experimental research instrumentation.
Candidates must hold a post-graduate qualification/PhD (or equivalent experience) in cell biology, molecular biology, cytometry, Biomolecular Science, or related subjects. We are looking for candidates with experience with standard molecular biology methodology, experience in mammalian cell culture techniques including organoid cultures and in microscopy techniques, as well as a demonstrated aptitude for multi-omics data interpretation.
Before submitting your application please ensure you read the Job Information Pack for full details of this role by clicking on the attachment on our website: https://opportunities.rfi.ac.uk/vacancy/postdoctoral-research-associate-in-single-cell-imaging-mass-spectrometry-----499048.html
The Rosalind Franklin Institute is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology.
Location: The Franklin is based in Harwell Campus, UK’s innovation hub and well-established as one of the leading science and innovation campuses in Europe.
Closing date: 17th October 2022 at 09:00am
Type of Post Full Time
Period of appointment 2 years fixed term contract
Salary £33,500 - £41,000 per annum
Closing Date 17/10/2022
Ref No 10232