Invasive lobular breast cancer (ILC) belongs to the spectrum of Oestrogen Receptor positive (ER+) breast cancers however patients respond less well to endocrine therapy, with unique metastatic patterns and higher rates of recurrence. There is an unmet clinical need to identify the molecular events that underpin this process and how they evolve over time. Moreover, identifying biomarkers that will aid in predicting which patients will relapse are much needed. Progress in this area has been hampered by the lack of clinically relevant models to study disease progression.
We are seeking a highly motivated collaborative Post Doctoral Training Fellow for a collaborative project co-supervised by Dr. Rachael Natrajan and Prof. Cathrin Brisken to lead on the biological and mechanistic insights into the sub-clonal evolution of metastasis in invasive lobular carcinomas using high throughput cellular tracking coupled with single cell sequencing and functional genomic approaches.
The candidate will perform experimental work to assess the implications of novel biology on tumour progression and test novel therapeutic approaches using innovative xenograft models and developing genetic screening approaches in patient-derived ER+ breast cancer models.
You should possess a PhD in biology, biochemistry, genetics or other associated subjects and have an excellent track record in biomedical research and experience in cell and molecular biology. Experience with in vitro and in vivo patient derived cancer models is desirable.
The teams sit within the Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research which is the first centre in the UK entirely devoted to breast cancer research and our goal is to advance research into the causes, diagnosis and treatment of breast cancer. The Centre is Directed by Professor Andrew Tutt and is located in state-of-the-art laboratory space, with excellent core facilities and funding.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, You may contact Dr Rachael Natrajan by emailing
[email protected]