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Postdoctoral researcher (m/f/d), Translational Research Lab (Hematopoietic Stem Cells and Acute Myeloid Leukemia)



The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,700 employees in more than 50 specialized clinical departments with almost 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

Translational Research Lab to work at Heidelberg University Hospital, Medical Department V (https://www.klinikum.uni-heidelberg.de/kliniken-institute/kliniken/zentrum-fuer-innere-medizin-krehl-klinik/innere-medizin-v-haematologie-onkologie-und-rheumatologie).

The position is limited to 3 years. With option of further extension. Salary: Salary (TV-L)

At the Heidelberg University Hospital, Department of Hematology, Oncology and Rheumatology, we are offering a postdoctoral fellow position in the research group of Dr. med. Caroline Pabst (Pabst Lab: https://www.klinikum.uni-heidelberg.de/en/kliniken-institute/kliniken/zentrum-fuer-innere-medizin-krehl-klinik/innere-medizin-v-haematologie-onkologie-und-rheumatologie/forschung/ag-pabst-max-eder-nachwuchsgruppe/eng-max-eder-junior-research-group-pabst) for 3 years in full-time with the option of further extension. Starting date: as soon as possible. We are searching for a highly motivated and dedicated researcher with a PhD degree or equivalent and a strong background in molecular biology and/or cell biology and great enthusiasm for hematology. The postdoc fellow will work on different third-party funded projects with a common aim to dissect how stem cell associated genes drive leukemogenesis and relapse in AML. Ideally, the candidate has expertise in gene editing (CRISPR), shRNA design, next-gen-sequencing techniques, and in vivo experiments. We aim to understand how genes that induce or maintain stem cell properties participate in the pathogenesis and chemo-resistance of AML. To achieve this aim a broad number of in-vitro- and in-vivo-models are available in our lab including access to a biobank of primary human patient cells. We are also closely collaborating with labs at EMBL via our Molecular Medicine Partnership Unit (MMPU SCN: https://www.embl.org/about/info/mmpu/research-groups/stem-cell-niche-networks/). The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients.

Tasks and responsibilities
• Driving independently the experimental and project designs
• Taking part in regular lab meetings, presenting data at internal and international conferences
• Contributing to the good team spirit and supporting PhD/MD students with advice
• Analyzing scientific data, writing manuscripts, taking part in the submission/publication process

Prerequisites
• PhD in biology, biochemistry or equivalent
• Broad expertise in basic cell- molecular and biochemical techniques
• Experience and skills in the following techniques: xenotransplantation, mice handling, Next-Generation-Sequencing, CRISPR/CAS9, shRNA- mediated knock down and genome editing techniques
• Experience and high motivation to work with mice and primary patient cells
• Rapid understanding and independent analysis of complex data
• Very good knowledge of and experience with Microsoft Office and graphic programs, statistical software, bioinformatics tools and online tools (e.g. Illustrator, Lightroom, GraphPadPrism, R, BLAST)
• Strong communication skills (oral presentations and writing)
• Fluent both in written and spoken English (knowledge of the German language is welcome but not required)

We offer
• Target-oriented individual further education and training opportunities
• Targeted training on the job
• Ticket for public transport
• Possibility of child care (crèche and kindergarten) as well as subsidy for holiday care for school children
• Active health promotion
• Company pension scheme
• Access to the university library and other university facilities (e.g. university sports)

We stand for equal opportunities. People with disabilities are given priority with the same suitability. The university hospital aims at a general increase in the proportion of women in all areas and positions where women are underrepresented. Qualified women are therefore particularly encouraged to apply.

Contact & Application
For further Information please contact Dr. med. Caroline Pabst via [email protected]

Applications will be accepted until 31.12.2021 online (https://karriere.klinikum.uni-heidelberg.de/stellenangebot/14040/Postdoctoral-researcher-%28m%7Cf%7Cd%29%2C-Translational-Research-Lab-%28Hematopoietic-Stem-Cells-and-Acute-Myeloid-Leukemia%29.html).

Universitätsklinikum Heidelberg
Zentrum für Innere Medizin
Klinik für Hämatologie, Onkologie, Rheumatologie (Innere Medizin V)
Dr. med. Caroline Pabst, Group Leader
Im Neuenheimer Feld 410
69120 Heidelberg
phone: +49 (0)6221 56-34121
[email protected]

www.klinikum.uni-heidelberg.de/karriere


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