Cell Biology of Liver Metabolism (m/f/x) 101294

Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the pre­vention and therapy of environ­mentally triggered diseases and promote a healthier society in a rapidly changing world.

Obesity and diabetes have become epi­demic over the last 20 years. Although lots of know­ledge has been collected regarding the patho­genesis of these diseases, the intra­cellular regulatory mechanisms are still not resolved. The group of Anja Zeigerer, located at the Institute for Diabetes and Cancer, investigates the role of mem­brane trafficking in metabolic homeo­stasis. The lab is seeking to the next possible time point a highly motivated

Your responsibilities
to investigate the function of Rab GTPase in mito­chondrial fission and protein secretion during the fasting / feeding transition in the liver. This project is part of colla­borative effort with the Munich Cluster of Systems Neuro­logy headed by Prof. Christian Behrends at the Ludwig-Maximilians-University (LMU) Munich.

-Planning and realization of experi­mental studies in the areas of cell bio­logy and membrane trafficking with connec­tion to liver physiology of fasting and feeding Biochemical, cell biological and immuno­fluorescence analysis of cell and tissue samples.

-Primary cell culture of murine and human hepato­cytes and analysis of tissues from diffe­rent mouse models to investi­gate their contribution to the fasting / feeding switch

-“Omics” data analysis, graphi­cal documentation, and evaluation for con­ferences, scientific publi­cations, and reports

Your qualifications
-PhD or equivalent level of pro­fessional qualification in biochemistry or cell biology

-Strong theoretical and practical back­ground on intracellular membrane trafficking required
Experience with complex methods in mole­cular biology and biochemistry

-Knowledge in hepatocellular meta­bolism and physiology are a plus

-Experience in primary cell cul­ture, imaging, and mouse work

-High motivation, flexibility, as well as inno­vate and creative thinking are a must

-A strong academic record, inter­national experience, and pro­ficiency in English are required

What we offer you
-Continuous education and training
-Work-life balance
-Flexible working hours & time off in lieu
-30 days annual leave
-On-site health management service
-Mobile work
-On-site nursery
-Elder care
-Company pension scheme
-Discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is con­sidered to be one of the cities with the best quality of life world­wide. With its first-class universities and world-leading research insti­tutions it offers an intellectually stimulating environment.
Remuneration and social benefits are based on the collec­tive wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to three years, but under certain circum­stances an extension can be arranged.

To promote diversity, we welcome applications from talen­ted people regardless of cultural back­ground, nationality, ethnicity, gender and sexual identity, physical abilities, religion, and age. Qualified appli­cants with physical disabilities will be given preference.

If you have obtained a university degree abroad, we require further docu­ments from you regar­ding the recognition of the degree. Please request the recognition as early as possible.


Interested?
If you have further questions, simply contact Miriam Guhl, +49 89 3187-1046, and Anja Zeigerer, +49 89 3187-1048, who will be happy to be of assistance.

Please upload your online appli­cation including a cover letter, detailed CV, copies of your certifi­cates, as well as at least two letters of recommendation.

Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Diabetes and Cancer
Ingolstädter Landstraße 1
85764 Oberschleißheim

Award for excellent gender equality policy for women and men. Helmholtz Zentrum München is parti­cularly committed to promoting pro­fessional equality between women and men. It there­fore aims to increase the proportion of the under­represented sex in the res­pective field.

The Helmholtz Zentrum München is part of the Helm­holtz Association, Germany’s lar­gest scientific organi­zation. Altogether 42,000 people current­ly work in its 19 scientific-tech­nical and biological-medical research centers. The Association’s annual budget amounts to around 5 billion euros.